Gonadotropin-Releasing Hormone Agonist (GnRH-a) Therapy Alters Activity of Plasminogen Activators, Matrix Metalloproteinases, and Their Inhibitors in Rat Models for Adhesion Formation and Endometriosis: Potential GnRH-a–Regulated Mechanisms Reducing Adhesion Formation

Objective: To evaluate the effects of a gonadotropin-releasing hormone agonist (GnRH-a) on plasminogen activator (PA), matrix metalloproteinase (MMP), plasminogen activator inhibitor (PAI) and matrix metalloproteinase inhibitor (MMPI) activities in peritoneal fluid relative to GnRH-a–induced reducti...

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Veröffentlicht in:	Fertility and sterility 1998-05, Vol.69 (5), p.916-923
Hauptverfasser:	Sharpe-Timms, Kathy L, Zimmer, Randall L, Jolliff, Wendy J, Wright, Jean A, Nothnick, Warren B, Curry, Thomas E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesions Animals Biological and medical sciences Disease Models, Animal endometriosis Endometriosis - metabolism enzyme inhibitors Female Hormones. Endocrine system Leuprolide - therapeutic use matrix metalloproteinase Medical sciences Metalloendopeptidases - analysis Metalloendopeptidases - antagonists & inhibitors peritoneum Pharmacology. Drug treatments plasminogen activator Plasminogen Activators - analysis Plasminogen Inactivators - analysis Rats Rats, Sprague-Dawley Tissue Adhesions - prevention & control
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