Salmonella typhi uses CFTR to enter intestinal epithelial cells

Homozygous mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis (CF). In the heterozygous state, increased resistance to infectious diseases may maintain mutant CFTR alleles at high levels in selected populations. Here we investigate whether typhoid fever...

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Veröffentlicht in:	Nature (London) 1998-05, Vol.393 (6680), p.79-82
Hauptverfasser:	Pier, Gerald B, Grout, Martha, Zaidi, Tanweer, Meluleni, Gloria, Mueschenborn, Simone S, Banting, George, Ratcliff, Rosemary, Evans, Martin J, Colledge, William H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Bacteriology Biochemistry Biological and medical sciences Cell Line Colon - microbiology Cystic fibrosis Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Epithelium - microbiology Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Humans Infectious diseases Intestinal Mucosa - microbiology Intestines - metabolism Intestines - microbiology Intestines - ultrastructure Jejunum - microbiology Jejunum - ultrastructure letter Mice Mice, Inbred BALB C Mice, Transgenic Microbiology Mucous Membrane - microbiology multidisciplinary Mutation Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Peptides Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Recombinant Proteins Salmonella Salmonella typhi Salmonella typhi - pathogenicity Salmonella typhi - physiology Salmonella typhi - ultrastructure Salmonella typhimurium Salmonella typhimurium - physiology Science Science (multidisciplinary) Translocation Tumor Cells, Cultured Typhoid Waterborne diseases
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