Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

During hedgehog biosynthesis, autocatalytic processing produces a lipid-modified amino-terminal fragment (residues 24–197 in the human Sonic hedgehog sequence) that is responsible for all known hedgehog signaling activity and that is highly conserved evolutionarily. Published in vitro biochemical st...

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Veröffentlicht in:	The Journal of biological chemistry 1998-05, Vol.273 (22), p.14037-14045
Hauptverfasser:	Pepinsky, R. Blake, Zeng, Chenhui, Wen, Dingyi, Rayhorn, Paul, Baker, Darren P., Williams, Kevin P., Bixler, Sarah A., Ambrose, Christine M., Garber, Ellen A., Miatkowski, Konrad, Taylor, Frederick R., Wang, Elizabeth A., Galdes, Alphonse
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cholesterol - chemistry Hedgehog Proteins Humans Mice Mice, Inbred C3H Palmitic Acid - chemistry Peptide Mapping Proteins - chemistry Proteins - genetics Proteins - metabolism Rats Signal Transduction Trans-Activators
Online-Zugang:	Volltext
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