Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300

The transcriptional coactivator and integrator p300 and its closely related family member CBP mediate multiple, signal-dependent transcriptional events. We have generated mice lacking a functional p300 gene. Animals nullizygous for p300 died between days 9 and 11.5 of gestation, exhibiting defects i...

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Veröffentlicht in:	Cell 1998-05, Vol.93 (3), p.361-372
Hauptverfasser:	Yao, Tso-Pang, Oh, Suk P, Fuchs, Miriam, Zhou, Nai-Dong, Ch'ng, Lian-Ee, Newsome, David, Bronson, Roderick T, Li, En, Livingston, David M, Eckner, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - abnormalities CCAAT-Enhancer-Binding Proteins Cell Division Cells, Cultured Crosses, Genetic DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Embryonic and Fetal Development - genetics Fibroblasts - cytology Gene Dosage Gene Expression Regulation, Developmental - physiology Heart - embryology Heterozygote Histone Acetyltransferases Mice Mice, Inbred C57BL Mice, Knockout Neural Tube Defects - genetics Nuclear Proteins - genetics Nuclear Proteins - physiology Nuclear Receptor Coactivator 3 Receptors, Retinoic Acid - genetics Trans-Activators - genetics Trans-Activators - physiology Transcription, Genetic
Online-Zugang:	Volltext
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