5-HT1B receptor binding in degenerative movement disorders

Using [3H]sumatriptan as a radioligand, 5-hydroxytryptamine (5-HT)1B receptors were examined in posterior striatum and midbrain post-mortem tissue sections of 12 patients who had died from representative degenerative movement disorders as compared to nine controls. In the control human basal ganglia...

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Veröffentlicht in:	Brain research 1998-04, Vol.790 (1-2), p.323-328
Hauptverfasser:	CASTRO, M. E, PASCUAL, J, ROMON, T, BERCIANO, J, FIGOLS, J, PAZOS, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Corpus Striatum - chemistry Corpus Striatum - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Huntington Disease - metabolism Huntington Disease - pathology Male Medical sciences Middle Aged Movement Disorders - metabolism Movement Disorders - pathology Nerve Degeneration - metabolism Nerve Degeneration - pathology Neurology Parkinson Disease - metabolism Parkinson Disease - pathology Radioligand Assay Receptor, Serotonin, 5-HT1B Receptors, Serotonin - analysis Receptors, Serotonin - metabolism Serotonin Receptor Agonists - metabolism Serotonin Receptor Agonists - pharmacology Substantia Nigra - chemistry Substantia Nigra - pathology Sumatriptan - metabolism Sumatriptan - pharmacology Supranuclear Palsy, Progressive - metabolism Supranuclear Palsy, Progressive - pathology Tritium
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