Syk Activation Is Required for Spreading and H2O2 Release in Adherent Human Neutrophils

Chemoattractant-stimulated polymorphonuclear leukocytes (PMNs) that are adherent to extracellular matrix proteins exhibit a massive, sustained respiratory burst that requires cell spreading. However, the signaling pathways culminating in PMN spreading are not well characterized. Studies showing that...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-05, Vol.160 (10), p.5154-5162
Hauptverfasser:	Fernandez, Rosemarie, Suchard, Suzanne J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Adhesion Molecules - metabolism Cytoskeletal Proteins - metabolism Enzyme Activation Enzyme Precursors - physiology Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Humans Hydrogen Peroxide - metabolism Intracellular Signaling Peptides and Proteins N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - metabolism Paxillin Phosphoproteins - metabolism Phosphorylation Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - physiology Stilbenes - pharmacology Syk Kinase Tyrosine - metabolism
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