Identification, cloning and initial characterisation of FeuPQ in Brucella suis: a new sub-family of two-component regulatory systems
To cause disease, Brucella species have to adapt to a range of different environments. Environmental sensing and adaptive responses in bacteria often involve the concerted action of a two-component regulatory system, consisting of sensor and response regulator components. Amplification and sequence...
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| Veröffentlicht in: | FEMS microbiology letters 1998-05, Vol.162 (1), p.143-150 |
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| creator | Dorrell, N Spencer, S Foulonge, V Guigue-Talet, P O'Callaghan, D Wren, B.W |
| description | To cause disease, Brucella species have to adapt to a range of different environments. Environmental sensing and adaptive responses in bacteria often involve the concerted action of a two-component regulatory system, consisting of sensor and response regulator components. Amplification and sequence analysis of response regulators from Brucelia species identified a response regulator sequence with 96% similarity to Rhizobium leguminosarum FeuP. In R. leguminosarum, the FeuPQ two-component system is involved in the regulation of iron uptake. A Brucella suis feuP isogenic mutant was constructed but was not attenuated in the murine brucellosis model. The survival and multiplication of the mutant in macrophages was also unaffected. The FeuPQ regulon represents a newly characterised subfamily of response regulators. |
| doi_str_mv | 10.1111/j.1574-6968.1998.tb12991.x |
| format | Article |
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Environmental sensing and adaptive responses in bacteria often involve the concerted action of a two-component regulatory system, consisting of sensor and response regulator components. Amplification and sequence analysis of response regulators from Brucelia species identified a response regulator sequence with 96% similarity to Rhizobium leguminosarum FeuP. In R. leguminosarum, the FeuPQ two-component system is involved in the regulation of iron uptake. A Brucella suis feuP isogenic mutant was constructed but was not attenuated in the murine brucellosis model. The survival and multiplication of the mutant in macrophages was also unaffected. The FeuPQ regulon represents a newly characterised subfamily of response regulators.</description><identifier>ISSN: 0378-1097</identifier><identifier>EISSN: 1574-6968</identifier><identifier>DOI: 10.1111/j.1574-6968.1998.tb12991.x</identifier><identifier>PMID: 9595675</identifier><identifier>CODEN: FMLED7</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amino Acid Sequence ; Animals ; Bacterial Proteins ; Bacteriology ; Biological and medical sciences ; Brucella ; Brucella - genetics ; Brucella - growth & development ; Brucella - metabolism ; Brucella - pathogenicity ; Brucella melitensis - genetics ; Brucella suis ; Brucellosis ; Brucellosis - microbiology ; Cell Line ; Cloning ; Cloning, Molecular ; Deferoxamine - pharmacology ; DNA, Bacterial - analysis ; FeuPQ ; Fundamental and applied biological sciences. Psychology ; genbank/x87324 ; genbank/y13235 ; Humans ; Iron ; Isogenic mutant ; Macrophages ; Mice ; Mice, Inbred BALB C ; Microbiology ; Molecular Sequence Data ; Monocytes - microbiology ; Multiplication ; Mutation ; Permeability, membrane transport, intracellular transport ; PhoPQ ; Regulators ; Regulatory sequences ; Regulon - genetics ; Rhizobium leguminosarum ; sequence alignment ; Sequence Analysis, DNA ; sequence homology ; Sequence Homology, Amino Acid ; Spleen - microbiology ; Transcription Factors - genetics ; Transcription Factors - physiology ; Two‐component regulatory system</subject><ispartof>FEMS microbiology letters, 1998-05, Vol.162 (1), p.143-150</ispartof><rights>1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V. 1998</rights><rights>1998 INIST-CNRS</rights><rights>1998 Federation of European Microbiological Societies. 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Environmental sensing and adaptive responses in bacteria often involve the concerted action of a two-component regulatory system, consisting of sensor and response regulator components. Amplification and sequence analysis of response regulators from Brucelia species identified a response regulator sequence with 96% similarity to Rhizobium leguminosarum FeuP. In R. leguminosarum, the FeuPQ two-component system is involved in the regulation of iron uptake. A Brucella suis feuP isogenic mutant was constructed but was not attenuated in the murine brucellosis model. The survival and multiplication of the mutant in macrophages was also unaffected. The FeuPQ regulon represents a newly characterised subfamily of response regulators.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Bacterial Proteins</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Brucella</subject><subject>Brucella - genetics</subject><subject>Brucella - growth & development</subject><subject>Brucella - metabolism</subject><subject>Brucella - pathogenicity</subject><subject>Brucella melitensis - genetics</subject><subject>Brucella suis</subject><subject>Brucellosis</subject><subject>Brucellosis - microbiology</subject><subject>Cell Line</subject><subject>Cloning</subject><subject>Cloning, Molecular</subject><subject>Deferoxamine - pharmacology</subject><subject>DNA, Bacterial - analysis</subject><subject>FeuPQ</subject><subject>Fundamental and applied biological sciences. 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Academic</collection><jtitle>FEMS microbiology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dorrell, N</au><au>Spencer, S</au><au>Foulonge, V</au><au>Guigue-Talet, P</au><au>O'Callaghan, D</au><au>Wren, B.W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification, cloning and initial characterisation of FeuPQ in Brucella suis: a new sub-family of two-component regulatory systems</atitle><jtitle>FEMS microbiology letters</jtitle><addtitle>FEMS Microbiol Lett</addtitle><date>1998-05</date><risdate>1998</risdate><volume>162</volume><issue>1</issue><spage>143</spage><epage>150</epage><pages>143-150</pages><issn>0378-1097</issn><eissn>1574-6968</eissn><coden>FMLED7</coden><abstract>To cause disease, Brucella species have to adapt to a range of different environments. Environmental sensing and adaptive responses in bacteria often involve the concerted action of a two-component regulatory system, consisting of sensor and response regulator components. Amplification and sequence analysis of response regulators from Brucelia species identified a response regulator sequence with 96% similarity to Rhizobium leguminosarum FeuP. In R. leguminosarum, the FeuPQ two-component system is involved in the regulation of iron uptake. A Brucella suis feuP isogenic mutant was constructed but was not attenuated in the murine brucellosis model. The survival and multiplication of the mutant in macrophages was also unaffected. The FeuPQ regulon represents a newly characterised subfamily of response regulators.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9595675</pmid><doi>10.1111/j.1574-6968.1998.tb12991.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-1097 |
| ispartof | FEMS microbiology letters, 1998-05, Vol.162 (1), p.143-150 |
| issn | 0378-1097 1574-6968 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Animals Bacterial Proteins Bacteriology Biological and medical sciences Brucella Brucella - genetics Brucella - growth & development Brucella - metabolism Brucella - pathogenicity Brucella melitensis - genetics Brucella suis Brucellosis Brucellosis - microbiology Cell Line Cloning Cloning, Molecular Deferoxamine - pharmacology DNA, Bacterial - analysis FeuPQ Fundamental and applied biological sciences. Psychology genbank/x87324 genbank/y13235 Humans Iron Isogenic mutant Macrophages Mice Mice, Inbred BALB C Microbiology Molecular Sequence Data Monocytes - microbiology Multiplication Mutation Permeability, membrane transport, intracellular transport PhoPQ Regulators Regulatory sequences Regulon - genetics Rhizobium leguminosarum sequence alignment Sequence Analysis, DNA sequence homology Sequence Homology, Amino Acid Spleen - microbiology Transcription Factors - genetics Transcription Factors - physiology Two‐component regulatory system |
| title | Identification, cloning and initial characterisation of FeuPQ in Brucella suis: a new sub-family of two-component regulatory systems |
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