Stromal factors support the expansion of the whole hemopoietic spectrum from bone marrow CD34+DR- cells and of some hemopoietic subsets from CD34+ and CD34+DR+ cells

Ex vivo expanded bone marrow CD34+DR- cells could offer a graft devoid of malignant cells able to promptly reconstitute hemopoiesis after transplant. We investigated the specific expansion requirements of this subpopulation compared to the more mature CD34+ and CD34+DR+ populations. The role of stro...

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Veröffentlicht in:	Leukemia 1998-05, Vol.12 (5), p.735-745
Hauptverfasser:	HERMAN, P, FERRANT, A, DE BRUYERE, M, STRAETMANS, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - biosynthesis Antigens, CD - physiology Antigens, CD34 - biosynthesis Antigens, CD34 - physiology Biological and medical sciences Bone (long) Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Bone marrow transplantation CD34 antigen Cell culture Cell differentiation, maturation, development, hematopoiesis Cell Division - drug effects Cell Division - physiology Cell physiology Cells, Cultured Chemokine CCL3 Chemokine CCL4 Clone Cells Conditioning Culture Culture Media, Conditioned Fundamental and applied biological sciences. Psychology Granulocyte colony-stimulating factor Granulocyte Colony-Stimulating Factor - pharmacology Growth Substances - pharmacology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Hemopoiesis Humans Integrin beta3 Interleukin 11 Interleukin 3 Interleukin 6 Interleukin-11 - pharmacology Macrophage Inflammatory Proteins - pharmacology Megakaryocytes - cytology Megakaryocytes - drug effects Megakaryocytes - metabolism Molecular and cellular biology Platelet Membrane Glycoproteins - biosynthesis Platelet Membrane Glycoproteins - physiology Stem Cell Factor - pharmacology Stroma Stromal Cells - cytology Stromal Cells - metabolism Time Factors
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