Response of the septic vasculature to prolonged vasopressor therapy with N(omega)-monomethyl-L-arginine and epinephrine in canines

To investigate the effect of blocking nitric oxide production on cardiovascular function and survival in canine septic shock treated with or without a conventional vasopressor. Randomized, controlled trial. An animal research laboratory at the National Institutes of Health. Sixty purpose-bred beagle...

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Veröffentlicht in:	Critical care medicine 1998-05, Vol.26 (5), p.877-886
Hauptverfasser:	Freeman, B D, Zeni, F, Banks, S M, Eichacker, P Q, Bacher, J D, Garvey, E P, Tuttle, J V, Jurgensen, C H, Natanson, C, Danner, R L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dogs Drug Combinations Enzyme Inhibitors - therapeutic use Epinephrine - therapeutic use Escherichia coli Infections - drug therapy Hemodynamics - drug effects Nitric Oxide - biosynthesis Nitric Oxide - blood Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism omega-N-Methylarginine - therapeutic use Sepsis - drug therapy Vasoconstrictor Agents - therapeutic use
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