The role of mu and kappa opioid receptors within the periaqueductal gray in the expression of conditional hypoalgesia
The periaqueductal gray (PAG) is a midbrain structure involved in the modulation of pain and expression of classically conditioned fear responses. Non-selective opioid antagonists applied to the PAG block the expression of hypoalgesia in rats exposed to a Pavlovian signal for shock. This study was c...
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| Veröffentlicht in: | Brain research 1998-04, Vol.791 (1), p.83-89 |
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| creator | Bellgowan, Patrick S.F. Helmstetter, Fred J. |
| description | The periaqueductal gray (PAG) is a midbrain structure involved in the modulation of pain and expression of classically conditioned fear responses. Non-selective opioid antagonists applied to the PAG block the expression of hypoalgesia in rats exposed to a Pavlovian signal for shock. This study was conducted to determine the anatomical and pharmacological specificity of the PAG's role in conditional hypoalgesia. Rat subjects received injections of either the
mu opioid antagonist CTAP (6.6 nMol), the
kappa opioid antagonist Nor-binaltorphimine (Nor-BNI, 6.6 nMol) or saline. Injections were made into either the dorsolateral (dlPAG) or ventrolateral (vlPAG) PAG prior to the presentation of an auditory stimulus that had previously been paired with foot shock while measuring nociception with the radiant heat tail flick (TF) test. Elevation in TF latency in response to the auditory stimulus was blocked only by administration of CTAP into the vlPAG. These results suggest that conditional hypoalgesia (CHA) is subserved by
mu but not
kappa opioid receptors located in the vlPAG but not the dlPAG. |
| doi_str_mv | 10.1016/S0006-8993(98)00057-2 |
| format | Article |
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mu opioid antagonist CTAP (6.6 nMol), the
kappa opioid antagonist Nor-binaltorphimine (Nor-BNI, 6.6 nMol) or saline. Injections were made into either the dorsolateral (dlPAG) or ventrolateral (vlPAG) PAG prior to the presentation of an auditory stimulus that had previously been paired with foot shock while measuring nociception with the radiant heat tail flick (TF) test. Elevation in TF latency in response to the auditory stimulus was blocked only by administration of CTAP into the vlPAG. These results suggest that conditional hypoalgesia (CHA) is subserved by
mu but not
kappa opioid receptors located in the vlPAG but not the dlPAG.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(98)00057-2</identifier><identifier>PMID: 9593835</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Acoustic Stimulation ; Analgesia ; Analysis of Variance ; Animals ; Biological and medical sciences ; Conditioning, Classical - physiology ; Electroshock ; Fear - physiology ; Fundamental and applied biological sciences. Psychology ; Learning ; Male ; Microinjections ; Naltrexone - analogs & derivatives ; Naltrexone - pharmacology ; Narcotic Antagonists - pharmacology ; Nociception ; Opioid ; Pain Threshold - physiology ; Pavlovian conditioning ; Periaqueductal gray ; Periaqueductal Gray - physiology ; Rats ; Reaction Time - drug effects ; Receptors, Opioid, kappa - antagonists & inhibitors ; Receptors, Opioid, kappa - physiology ; Receptors, Opioid, mu - physiology ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Stress ; Tail flick ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1998-04, Vol.791 (1), p.83-89</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><rights>Copyright 1998 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-3c29b1dc88581c0077ad5ffa3e091bc67cf28c9bd8379cca9f7401cb07fa87ff3</citedby><cites>FETCH-LOGICAL-c486t-3c29b1dc88581c0077ad5ffa3e091bc67cf28c9bd8379cca9f7401cb07fa87ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899398000572$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2256659$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9593835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bellgowan, Patrick S.F.</creatorcontrib><creatorcontrib>Helmstetter, Fred J.</creatorcontrib><title>The role of mu and kappa opioid receptors within the periaqueductal gray in the expression of conditional hypoalgesia</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The periaqueductal gray (PAG) is a midbrain structure involved in the modulation of pain and expression of classically conditioned fear responses. Non-selective opioid antagonists applied to the PAG block the expression of hypoalgesia in rats exposed to a Pavlovian signal for shock. This study was conducted to determine the anatomical and pharmacological specificity of the PAG's role in conditional hypoalgesia. Rat subjects received injections of either the
mu opioid antagonist CTAP (6.6 nMol), the
kappa opioid antagonist Nor-binaltorphimine (Nor-BNI, 6.6 nMol) or saline. Injections were made into either the dorsolateral (dlPAG) or ventrolateral (vlPAG) PAG prior to the presentation of an auditory stimulus that had previously been paired with foot shock while measuring nociception with the radiant heat tail flick (TF) test. Elevation in TF latency in response to the auditory stimulus was blocked only by administration of CTAP into the vlPAG. These results suggest that conditional hypoalgesia (CHA) is subserved by
mu but not
kappa opioid receptors located in the vlPAG but not the dlPAG.</description><subject>Acoustic Stimulation</subject><subject>Analgesia</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Conditioning, Classical - physiology</subject><subject>Electroshock</subject><subject>Fear - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Learning</subject><subject>Male</subject><subject>Microinjections</subject><subject>Naltrexone - analogs & derivatives</subject><subject>Naltrexone - pharmacology</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Nociception</subject><subject>Opioid</subject><subject>Pain Threshold - physiology</subject><subject>Pavlovian conditioning</subject><subject>Periaqueductal gray</subject><subject>Periaqueductal Gray - physiology</subject><subject>Rats</subject><subject>Reaction Time - drug effects</subject><subject>Receptors, Opioid, kappa - antagonists & inhibitors</subject><subject>Receptors, Opioid, kappa - physiology</subject><subject>Receptors, Opioid, mu - physiology</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Stress</subject><subject>Tail flick</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKkvhJ1TyASE4BGxn448TQhVfUiUOlLPljMddQzYOdgLsv8fbjfba0-jVPO_MaF5Crjh7yxmX774zxmSjjWlfG_2mik414hHZcK1EI8WWPSabM_KUPCvlZ5Vta9gFuTCdaXXbbchyu0Oa04A0BbpfqBs9_eWmydE0xRQ9zQg4zSkX-jfOuzjSuRomzNH9XtAvMLuB3mV3oGsL_00ZS4lpPE6ENPo4V1Gp3WFKbrjDEt1z8iS4oeCLtV6SH58-3l5_aW6-ff56_eGmga2Wc9OCMD33oHWnOTCmlPNdCK5FZngPUkEQGkzvdasMgDNBbRmHnqngtAqhvSSvTnOnnOq5Zbb7WACHwY2YlmKV0aoTSj4IcrnVXEhTwe4EQk6lZAx2ynHv8sFyZo-52Ptc7PHp1mh7n4sV1Xe1Llj6Pfqzaw2i9l-ufVfADSG7EWI5Y0J0UnbH9e9PGNav_YmYbYGII6CPNajZ-hQfOOQ_Kz2sHw</recordid><startdate>19980427</startdate><enddate>19980427</enddate><creator>Bellgowan, Patrick S.F.</creator><creator>Helmstetter, Fred J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980427</creationdate><title>The role of mu and kappa opioid receptors within the periaqueductal gray in the expression of conditional hypoalgesia</title><author>Bellgowan, Patrick S.F. ; Helmstetter, Fred J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-3c29b1dc88581c0077ad5ffa3e091bc67cf28c9bd8379cca9f7401cb07fa87ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acoustic Stimulation</topic><topic>Analgesia</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Conditioning, Classical - physiology</topic><topic>Electroshock</topic><topic>Fear - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Learning</topic><topic>Male</topic><topic>Microinjections</topic><topic>Naltrexone - analogs & derivatives</topic><topic>Naltrexone - pharmacology</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Nociception</topic><topic>Opioid</topic><topic>Pain Threshold - physiology</topic><topic>Pavlovian conditioning</topic><topic>Periaqueductal gray</topic><topic>Periaqueductal Gray - physiology</topic><topic>Rats</topic><topic>Reaction Time - drug effects</topic><topic>Receptors, Opioid, kappa - antagonists & inhibitors</topic><topic>Receptors, Opioid, kappa - physiology</topic><topic>Receptors, Opioid, mu - physiology</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Stress</topic><topic>Tail flick</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bellgowan, Patrick S.F.</creatorcontrib><creatorcontrib>Helmstetter, Fred J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bellgowan, Patrick S.F.</au><au>Helmstetter, Fred J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of mu and kappa opioid receptors within the periaqueductal gray in the expression of conditional hypoalgesia</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1998-04-27</date><risdate>1998</risdate><volume>791</volume><issue>1</issue><spage>83</spage><epage>89</epage><pages>83-89</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The periaqueductal gray (PAG) is a midbrain structure involved in the modulation of pain and expression of classically conditioned fear responses. Non-selective opioid antagonists applied to the PAG block the expression of hypoalgesia in rats exposed to a Pavlovian signal for shock. This study was conducted to determine the anatomical and pharmacological specificity of the PAG's role in conditional hypoalgesia. Rat subjects received injections of either the
mu opioid antagonist CTAP (6.6 nMol), the
kappa opioid antagonist Nor-binaltorphimine (Nor-BNI, 6.6 nMol) or saline. Injections were made into either the dorsolateral (dlPAG) or ventrolateral (vlPAG) PAG prior to the presentation of an auditory stimulus that had previously been paired with foot shock while measuring nociception with the radiant heat tail flick (TF) test. Elevation in TF latency in response to the auditory stimulus was blocked only by administration of CTAP into the vlPAG. These results suggest that conditional hypoalgesia (CHA) is subserved by
mu but not
kappa opioid receptors located in the vlPAG but not the dlPAG.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>9593835</pmid><doi>10.1016/S0006-8993(98)00057-2</doi><tpages>7</tpages></addata></record> |
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| subjects | Acoustic Stimulation Analgesia Analysis of Variance Animals Biological and medical sciences Conditioning, Classical - physiology Electroshock Fear - physiology Fundamental and applied biological sciences. Psychology Learning Male Microinjections Naltrexone - analogs & derivatives Naltrexone - pharmacology Narcotic Antagonists - pharmacology Nociception Opioid Pain Threshold - physiology Pavlovian conditioning Periaqueductal gray Periaqueductal Gray - physiology Rats Reaction Time - drug effects Receptors, Opioid, kappa - antagonists & inhibitors Receptors, Opioid, kappa - physiology Receptors, Opioid, mu - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Stress Tail flick Vertebrates: nervous system and sense organs |
| title | The role of mu and kappa opioid receptors within the periaqueductal gray in the expression of conditional hypoalgesia |
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