SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk

Membrane recruitment of SHIP is responsible for the inhibitory signal generated by FcγRIIB coligation to the BCR. By reducing the level of PIP3, SHIP regulates the association of the tyrosine kinase Btk with the membrane through PH domain–phosphoinositol lipid interactions. Inhibition of BCR signali...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 1998-04, Vol.8 (4), p.509-516
Hauptverfasser:	Bolland, Silvia, Pearse, Roger N, Kurosaki, Tomohiro, Ravetch, Jeffrey V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - immunology B-Lymphocytes - metabolism Calcium - metabolism Cell Line Cell Membrane - immunology Cell Membrane - metabolism Chickens Humans Models, Biological Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol Phosphates - metabolism Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - immunology Phosphoric Monoester Hydrolases - metabolism Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - immunology Protein-Tyrosine Kinases - metabolism Receptors, Antigen, B-Cell - metabolism Receptors, IgG - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - metabolism Signal Transduction
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