Components of the Signaling Pathway Linking the 1-Methyladenine Receptor to MPF Activation and Maturation in Starfish Oocytes

Starfish oocytes are arrested at the G2/M-phase border of meiosis I. Exposure to their natural mitogen, 1-methyladenine (1-MA), leads to the activation of MPF and MAP kinase, resumption of the meiotic cell cycle, and fertilization competency. The 1-MA receptor has not yet been identified, but it is...

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Veröffentlicht in:	Developmental biology 1998-05, Vol.197 (1), p.25-38
Hauptverfasser:	Sadler, Kirsten C., Ruderman, Joan V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cells, Cultured Chromones - pharmacology DNA Replication Enzyme Activation Enzyme Inhibitors - pharmacology G2 Phase Maturation-Promoting Factor - metabolism Mitosis Morpholines - pharmacology Oocytes - enzymology Oocytes - growth & development Phosphatidylinositol 3-Kinases - metabolism Receptors, Cell Surface - physiology Receptors, G-Protein-Coupled Signal Transduction Starfish
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