Differential Effects of Prenatal Stress in Two Inbred Strains of Rats
STÖHR, T., D. SCHULTE WERMELING, T. SZURAN, V. PLISKA, A. DOMENEY, H. WELZL, I. WEINERAND J. FELDON. Differential effects of prenatal stress in two inbred strains of rats. 〈Default ¶ Font>PHARMACOL BIOCHEM BEHAV 59(4) 799–805, 1998.—The long-term effects of prenatal stress (three times daily rest...
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| description | STÖHR, T., D. SCHULTE WERMELING, T. SZURAN, V. PLISKA, A. DOMENEY, H. WELZL, I. WEINERAND J. FELDON.
Differential effects of prenatal stress in two inbred strains of rats. 〈Default ¶ Font>PHARMACOL BIOCHEM BEHAV
59(4) 799–805, 1998.—The long-term effects of prenatal stress (three times daily restraint stress during the last week of gestation) on the behavioral response to stress, as assessed by novelty-induced locomotion, performance in the forced swim test, and the acquisition of a two-way active avoidance, were investigated in two inbred strains of rats, Fischer 344 (F344/NHsd/Zur) and Lewis (LEW/SsNHsd/Zur). Additional measures included birth weights, pain threshold on the hot plate, and basal and stress-induced corticosterone secretion. In all of the behavioral paradigms strain differences were found: LEW rats showed poorer acquisition of avoidance conditioning, displayed higher levels of activity on the open plate, less immobility time in the forced swim test, and lower pain thresholds in the hot-plate test compared with F344 rats. LEW rats had higher birth weights after prenatal stress, whereas F344 rats were lighter. Following prenatal stress the pattern of behavioral effects obtained in LEW rats in stress-related tests could be interpreted as improved coping abilities with stress, i.e., improved acquisition of active avoidance, less immobility in the forced swim test, and reduced novelty-induced locomotion. Prenatal stress was much less effective in inducing long-term behavioral changes in F344 rats, yielding only one effect, namely, enhanced novelty-induced locomotion in female F344 rats. Pain thresholds were increased as a consequence of prenatal stress, irrespective of strain and gender. Basal and stress-induced corticosterone release differed in the two strains, with LEW rats showing less stress-induced corticosterone release. Prenatal stress did not, however, affect basal or stress-induced corticosterone release. The results suggest that prenatal stress exerts long-term effects on behavior, which depend on the genetic background. |
| doi_str_mv | 10.1016/S0091-3057(97)00541-8 |
| format | Article |
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Differential effects of prenatal stress in two inbred strains of rats. 〈Default ¶ Font>PHARMACOL BIOCHEM BEHAV
59(4) 799–805, 1998.—The long-term effects of prenatal stress (three times daily restraint stress during the last week of gestation) on the behavioral response to stress, as assessed by novelty-induced locomotion, performance in the forced swim test, and the acquisition of a two-way active avoidance, were investigated in two inbred strains of rats, Fischer 344 (F344/NHsd/Zur) and Lewis (LEW/SsNHsd/Zur). Additional measures included birth weights, pain threshold on the hot plate, and basal and stress-induced corticosterone secretion. In all of the behavioral paradigms strain differences were found: LEW rats showed poorer acquisition of avoidance conditioning, displayed higher levels of activity on the open plate, less immobility time in the forced swim test, and lower pain thresholds in the hot-plate test compared with F344 rats. LEW rats had higher birth weights after prenatal stress, whereas F344 rats were lighter. Following prenatal stress the pattern of behavioral effects obtained in LEW rats in stress-related tests could be interpreted as improved coping abilities with stress, i.e., improved acquisition of active avoidance, less immobility in the forced swim test, and reduced novelty-induced locomotion. Prenatal stress was much less effective in inducing long-term behavioral changes in F344 rats, yielding only one effect, namely, enhanced novelty-induced locomotion in female F344 rats. Pain thresholds were increased as a consequence of prenatal stress, irrespective of strain and gender. Basal and stress-induced corticosterone release differed in the two strains, with LEW rats showing less stress-induced corticosterone release. Prenatal stress did not, however, affect basal or stress-induced corticosterone release. The results suggest that prenatal stress exerts long-term effects on behavior, which depend on the genetic background.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(97)00541-8</identifier><identifier>PMID: 9586834</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Avoidance Learning - physiology ; Body Weight - physiology ; Corticosterone - blood ; Depression - psychology ; Female ; Fischer rat ; Gender differences ; Genetic differences ; Hot Temperature ; HPA system ; Lewis rat ; Male ; Motor Activity - physiology ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prenatal stress ; Rats ; Rats, Inbred F344 ; Rats, Inbred Lew ; Reaction Time - physiology ; Sex Characteristics ; Species Specificity ; Stress, Psychological - physiopathology ; Stress, Psychological - psychology</subject><ispartof>Pharmacology, biochemistry and behavior, 1998-04, Vol.59 (4), p.799-805</ispartof><rights>1998 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-f8e3c54db3a75809da3bc9bd25570b1d5abcdb491320a647ad41806a657f76dd3</citedby><cites>FETCH-LOGICAL-c391t-f8e3c54db3a75809da3bc9bd25570b1d5abcdb491320a647ad41806a657f76dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0091-3057(97)00541-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9586834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stöhr, T</creatorcontrib><creatorcontrib>Wermeling, D.Schulte</creatorcontrib><creatorcontrib>Szuran, T</creatorcontrib><creatorcontrib>Pliska, V</creatorcontrib><creatorcontrib>Domeney, A</creatorcontrib><creatorcontrib>Welzl, H</creatorcontrib><creatorcontrib>Weiner, I</creatorcontrib><creatorcontrib>Feldon, J</creatorcontrib><title>Differential Effects of Prenatal Stress in Two Inbred Strains of Rats</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>STÖHR, T., D. SCHULTE WERMELING, T. SZURAN, V. PLISKA, A. DOMENEY, H. WELZL, I. WEINERAND J. FELDON.
Differential effects of prenatal stress in two inbred strains of rats. 〈Default ¶ Font>PHARMACOL BIOCHEM BEHAV
59(4) 799–805, 1998.—The long-term effects of prenatal stress (three times daily restraint stress during the last week of gestation) on the behavioral response to stress, as assessed by novelty-induced locomotion, performance in the forced swim test, and the acquisition of a two-way active avoidance, were investigated in two inbred strains of rats, Fischer 344 (F344/NHsd/Zur) and Lewis (LEW/SsNHsd/Zur). Additional measures included birth weights, pain threshold on the hot plate, and basal and stress-induced corticosterone secretion. In all of the behavioral paradigms strain differences were found: LEW rats showed poorer acquisition of avoidance conditioning, displayed higher levels of activity on the open plate, less immobility time in the forced swim test, and lower pain thresholds in the hot-plate test compared with F344 rats. LEW rats had higher birth weights after prenatal stress, whereas F344 rats were lighter. Following prenatal stress the pattern of behavioral effects obtained in LEW rats in stress-related tests could be interpreted as improved coping abilities with stress, i.e., improved acquisition of active avoidance, less immobility in the forced swim test, and reduced novelty-induced locomotion. Prenatal stress was much less effective in inducing long-term behavioral changes in F344 rats, yielding only one effect, namely, enhanced novelty-induced locomotion in female F344 rats. Pain thresholds were increased as a consequence of prenatal stress, irrespective of strain and gender. Basal and stress-induced corticosterone release differed in the two strains, with LEW rats showing less stress-induced corticosterone release. Prenatal stress did not, however, affect basal or stress-induced corticosterone release. The results suggest that prenatal stress exerts long-term effects on behavior, which depend on the genetic background.</description><subject>Animals</subject><subject>Avoidance Learning - physiology</subject><subject>Body Weight - physiology</subject><subject>Corticosterone - blood</subject><subject>Depression - psychology</subject><subject>Female</subject><subject>Fischer rat</subject><subject>Gender differences</subject><subject>Genetic differences</subject><subject>Hot Temperature</subject><subject>HPA system</subject><subject>Lewis rat</subject><subject>Male</subject><subject>Motor Activity - physiology</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prenatal stress</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rats, Inbred Lew</subject><subject>Reaction Time - physiology</subject><subject>Sex Characteristics</subject><subject>Species Specificity</subject><subject>Stress, Psychological - physiopathology</subject><subject>Stress, Psychological - psychology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVZ_QmFPoofVySbZJCeRWrVQUGw9h2yShUi7W5Ot4r83_aDXnmZ455kZeBAaYrjDgMv7GYDEOQHGbyS_BWAU5-IE9bHgJGeY81PUPyDn6CLGLwCgRcl7qCeZKAWhfTR-8nXtgms6rxfZOPWmi1lbZ-8p013KZl1wMWa-yea_bTZpquDsJtS-2YIfuouX6KzWi-iu9nWAPp_H89FrPn17mYwep7khEnd5LRwxjNqKaM4ESKtJZWRlC8Y4VNgyXRlbUYlJAbqkXFuKBZS6ZLzmpbVkgK53d1eh_V672Kmlj8YtFrpx7ToqLgUvKJCjIE5YSQtIINuBJrQxBlerVfBLHf4UBrXxrLae1UaiklxtPSuR9ob7B-tq6exhay82zR92c5d0_HgXVDTeNcZZH5JiZVt_5MM_g7SLyw</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Stöhr, T</creator><creator>Wermeling, D.Schulte</creator><creator>Szuran, T</creator><creator>Pliska, V</creator><creator>Domeney, A</creator><creator>Welzl, H</creator><creator>Weiner, I</creator><creator>Feldon, J</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Differential Effects of Prenatal Stress in Two Inbred Strains of Rats</title><author>Stöhr, T ; Wermeling, D.Schulte ; Szuran, T ; Pliska, V ; Domeney, A ; Welzl, H ; Weiner, I ; Feldon, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-f8e3c54db3a75809da3bc9bd25570b1d5abcdb491320a647ad41806a657f76dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Avoidance Learning - physiology</topic><topic>Body Weight - physiology</topic><topic>Corticosterone - blood</topic><topic>Depression - psychology</topic><topic>Female</topic><topic>Fischer rat</topic><topic>Gender differences</topic><topic>Genetic differences</topic><topic>Hot Temperature</topic><topic>HPA system</topic><topic>Lewis rat</topic><topic>Male</topic><topic>Motor Activity - physiology</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prenatal stress</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rats, Inbred Lew</topic><topic>Reaction Time - physiology</topic><topic>Sex Characteristics</topic><topic>Species Specificity</topic><topic>Stress, Psychological - physiopathology</topic><topic>Stress, Psychological - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stöhr, T</creatorcontrib><creatorcontrib>Wermeling, D.Schulte</creatorcontrib><creatorcontrib>Szuran, T</creatorcontrib><creatorcontrib>Pliska, V</creatorcontrib><creatorcontrib>Domeney, A</creatorcontrib><creatorcontrib>Welzl, H</creatorcontrib><creatorcontrib>Weiner, I</creatorcontrib><creatorcontrib>Feldon, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stöhr, T</au><au>Wermeling, D.Schulte</au><au>Szuran, T</au><au>Pliska, V</au><au>Domeney, A</au><au>Welzl, H</au><au>Weiner, I</au><au>Feldon, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Effects of Prenatal Stress in Two Inbred Strains of Rats</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>59</volume><issue>4</issue><spage>799</spage><epage>805</epage><pages>799-805</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><abstract>STÖHR, T., D. SCHULTE WERMELING, T. SZURAN, V. PLISKA, A. DOMENEY, H. WELZL, I. WEINERAND J. FELDON.
Differential effects of prenatal stress in two inbred strains of rats. 〈Default ¶ Font>PHARMACOL BIOCHEM BEHAV
59(4) 799–805, 1998.—The long-term effects of prenatal stress (three times daily restraint stress during the last week of gestation) on the behavioral response to stress, as assessed by novelty-induced locomotion, performance in the forced swim test, and the acquisition of a two-way active avoidance, were investigated in two inbred strains of rats, Fischer 344 (F344/NHsd/Zur) and Lewis (LEW/SsNHsd/Zur). Additional measures included birth weights, pain threshold on the hot plate, and basal and stress-induced corticosterone secretion. In all of the behavioral paradigms strain differences were found: LEW rats showed poorer acquisition of avoidance conditioning, displayed higher levels of activity on the open plate, less immobility time in the forced swim test, and lower pain thresholds in the hot-plate test compared with F344 rats. LEW rats had higher birth weights after prenatal stress, whereas F344 rats were lighter. Following prenatal stress the pattern of behavioral effects obtained in LEW rats in stress-related tests could be interpreted as improved coping abilities with stress, i.e., improved acquisition of active avoidance, less immobility in the forced swim test, and reduced novelty-induced locomotion. Prenatal stress was much less effective in inducing long-term behavioral changes in F344 rats, yielding only one effect, namely, enhanced novelty-induced locomotion in female F344 rats. Pain thresholds were increased as a consequence of prenatal stress, irrespective of strain and gender. Basal and stress-induced corticosterone release differed in the two strains, with LEW rats showing less stress-induced corticosterone release. Prenatal stress did not, however, affect basal or stress-induced corticosterone release. The results suggest that prenatal stress exerts long-term effects on behavior, which depend on the genetic background.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9586834</pmid><doi>10.1016/S0091-3057(97)00541-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pharmacology, biochemistry and behavior, 1998-04, Vol.59 (4), p.799-805 |
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| subjects | Animals Avoidance Learning - physiology Body Weight - physiology Corticosterone - blood Depression - psychology Female Fischer rat Gender differences Genetic differences Hot Temperature HPA system Lewis rat Male Motor Activity - physiology Pregnancy Prenatal Exposure Delayed Effects Prenatal stress Rats Rats, Inbred F344 Rats, Inbred Lew Reaction Time - physiology Sex Characteristics Species Specificity Stress, Psychological - physiopathology Stress, Psychological - psychology |
| title | Differential Effects of Prenatal Stress in Two Inbred Strains of Rats |
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