The NMDA-receptor antagonist ketamine abolishes neuropathic pain after epidural administration in a clinical case
A 14-year-old male patient developed severe right limb pain after traumatic sciatic nerve injury. His pain was diagnosed as neuropathic pain (complex regional pain syndrome, type II). He did not respond to any conventional therapy for limb pain including non-steroidal anti-inflammatory drugs, antide...
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| Veröffentlicht in: | Pain (Amsterdam) 1998-04, Vol.75 (2), p.391-394 |
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| creator | Takahashi, Hidenori Miyazaki, Miyuki Nanbu, Takashi Yanagida, Hisashi Morita, Shigeho |
| description | A 14-year-old male patient developed severe right limb pain after traumatic sciatic nerve injury. His pain was diagnosed as neuropathic pain (complex regional pain syndrome, type II). He did not respond to any conventional therapy for limb pain including non-steroidal anti-inflammatory drugs, antidepressants, anticonvulsants, continuous epidural administration of local anesthetics and psychotherapy. Following continuous epidural administration of a very low dose of ketamine, an
N-methyl-
d-aspartic acid (NMDA) receptor antagonist, 25
μg/kg per h for 10 days, complete pain relief was obtained without any side-effects. There has been no recurrence of pain for 8 months after discontinuation of epidural ketamine. The symptoms related to dysfunction of the sympathetic nervous system still remained after complete pain relief. We discuss pain mechanisms, pain relief and the use of ketamine in this case. |
| doi_str_mv | 10.1016/S0304-3959(97)00189-9 |
| format | Article |
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N-methyl-
d-aspartic acid (NMDA) receptor antagonist, 25
μg/kg per h for 10 days, complete pain relief was obtained without any side-effects. There has been no recurrence of pain for 8 months after discontinuation of epidural ketamine. The symptoms related to dysfunction of the sympathetic nervous system still remained after complete pain relief. We discuss pain mechanisms, pain relief and the use of ketamine in this case.</description><identifier>ISSN: 0304-3959</identifier><identifier>EISSN: 1872-6623</identifier><identifier>DOI: 10.1016/S0304-3959(97)00189-9</identifier><identifier>PMID: 9583776</identifier><identifier>CODEN: PAINDB</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adolescent ; Analgesics ; Biological and medical sciences ; Causalgia - physiopathology ; Complex regional pain syndrome ; Epidural administration ; Humans ; Injections, Epidural ; Ketamine ; Ketamine - administration & dosage ; Ketamine - therapeutic use ; Leg ; Male ; Medical sciences ; N-Methyl- d-aspartic acid receptor antagonist ; Neuropathic pain ; Neuropharmacology ; Pain - physiopathology ; Pharmacology. Drug treatments ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Sciatic Nerve - injuries ; Wounds and Injuries - physiopathology</subject><ispartof>Pain (Amsterdam), 1998-04, Vol.75 (2), p.391-394</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-437494f348642d75beec9c25e1188fac6ba22e5a8bbd8e7bac6fc4d10c39fdb33</citedby><cites>FETCH-LOGICAL-c414t-437494f348642d75beec9c25e1188fac6ba22e5a8bbd8e7bac6fc4d10c39fdb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3959(97)00189-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2393504$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9583776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahashi, Hidenori</creatorcontrib><creatorcontrib>Miyazaki, Miyuki</creatorcontrib><creatorcontrib>Nanbu, Takashi</creatorcontrib><creatorcontrib>Yanagida, Hisashi</creatorcontrib><creatorcontrib>Morita, Shigeho</creatorcontrib><title>The NMDA-receptor antagonist ketamine abolishes neuropathic pain after epidural administration in a clinical case</title><title>Pain (Amsterdam)</title><addtitle>Pain</addtitle><description>A 14-year-old male patient developed severe right limb pain after traumatic sciatic nerve injury. His pain was diagnosed as neuropathic pain (complex regional pain syndrome, type II). He did not respond to any conventional therapy for limb pain including non-steroidal anti-inflammatory drugs, antidepressants, anticonvulsants, continuous epidural administration of local anesthetics and psychotherapy. Following continuous epidural administration of a very low dose of ketamine, an
N-methyl-
d-aspartic acid (NMDA) receptor antagonist, 25
μg/kg per h for 10 days, complete pain relief was obtained without any side-effects. There has been no recurrence of pain for 8 months after discontinuation of epidural ketamine. The symptoms related to dysfunction of the sympathetic nervous system still remained after complete pain relief. We discuss pain mechanisms, pain relief and the use of ketamine in this case.</description><subject>Adolescent</subject><subject>Analgesics</subject><subject>Biological and medical sciences</subject><subject>Causalgia - physiopathology</subject><subject>Complex regional pain syndrome</subject><subject>Epidural administration</subject><subject>Humans</subject><subject>Injections, Epidural</subject><subject>Ketamine</subject><subject>Ketamine - administration & dosage</subject><subject>Ketamine - therapeutic use</subject><subject>Leg</subject><subject>Male</subject><subject>Medical sciences</subject><subject>N-Methyl- d-aspartic acid receptor antagonist</subject><subject>Neuropathic pain</subject><subject>Neuropharmacology</subject><subject>Pain - physiopathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Sciatic Nerve - injuries</subject><subject>Wounds and Injuries - physiopathology</subject><issn>0304-3959</issn><issn>1872-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EKtPCI1TyAiFYBPyXOF6hqlBAKrCgrK0b-4YxZJzUdpB4ezyd0WxZWbrnO_75TMglZ284493b70wy1UjTmldGv2aM96Yxj8iG91o0XSfkY7I5IU_Jec6_GGNCCHNGzkzbS627Dbm_2yL9-uX9VZPQ4VLmRCEW-DnHkAv9jQV2ISKFYZ5C3mKmEdc0L1C2wdEFQqQwFkwUl-DXBBMFXwu1m6CEOdI9QN1UR66GDjI-I09GmDI-P64X5MfNh7vrT83tt4-fr69uG6e4Ko2SWhk1StV3SnjdDojOONEi530_gusGEAJb6IfB96iHOhmd8pw5aUY_SHlBXh72XdJ8v2Iudheyw2mCiPOarTZVFBe6gu0BdGnOOeFolxR2kP5azuxetX1QbfcerdH2QbU1tXd5PGAdduhPraPbmr845pDr48cE0YV8woQ0smWqYu8OGFYZfwImm13A6NCH-iXF-jn85yL_ABCbnUo</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Takahashi, Hidenori</creator><creator>Miyazaki, Miyuki</creator><creator>Nanbu, Takashi</creator><creator>Yanagida, Hisashi</creator><creator>Morita, Shigeho</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>The NMDA-receptor antagonist ketamine abolishes neuropathic pain after epidural administration in a clinical case</title><author>Takahashi, Hidenori ; Miyazaki, Miyuki ; Nanbu, Takashi ; Yanagida, Hisashi ; Morita, Shigeho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-437494f348642d75beec9c25e1188fac6ba22e5a8bbd8e7bac6fc4d10c39fdb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Analgesics</topic><topic>Biological and medical sciences</topic><topic>Causalgia - physiopathology</topic><topic>Complex regional pain syndrome</topic><topic>Epidural administration</topic><topic>Humans</topic><topic>Injections, Epidural</topic><topic>Ketamine</topic><topic>Ketamine - administration & dosage</topic><topic>Ketamine - therapeutic use</topic><topic>Leg</topic><topic>Male</topic><topic>Medical sciences</topic><topic>N-Methyl- d-aspartic acid receptor antagonist</topic><topic>Neuropathic pain</topic><topic>Neuropharmacology</topic><topic>Pain - physiopathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Sciatic Nerve - injuries</topic><topic>Wounds and Injuries - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Hidenori</creatorcontrib><creatorcontrib>Miyazaki, Miyuki</creatorcontrib><creatorcontrib>Nanbu, Takashi</creatorcontrib><creatorcontrib>Yanagida, Hisashi</creatorcontrib><creatorcontrib>Morita, Shigeho</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pain (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Hidenori</au><au>Miyazaki, Miyuki</au><au>Nanbu, Takashi</au><au>Yanagida, Hisashi</au><au>Morita, Shigeho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The NMDA-receptor antagonist ketamine abolishes neuropathic pain after epidural administration in a clinical case</atitle><jtitle>Pain (Amsterdam)</jtitle><addtitle>Pain</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>75</volume><issue>2</issue><spage>391</spage><epage>394</epage><pages>391-394</pages><issn>0304-3959</issn><eissn>1872-6623</eissn><coden>PAINDB</coden><abstract>A 14-year-old male patient developed severe right limb pain after traumatic sciatic nerve injury. His pain was diagnosed as neuropathic pain (complex regional pain syndrome, type II). He did not respond to any conventional therapy for limb pain including non-steroidal anti-inflammatory drugs, antidepressants, anticonvulsants, continuous epidural administration of local anesthetics and psychotherapy. Following continuous epidural administration of a very low dose of ketamine, an
N-methyl-
d-aspartic acid (NMDA) receptor antagonist, 25
μg/kg per h for 10 days, complete pain relief was obtained without any side-effects. There has been no recurrence of pain for 8 months after discontinuation of epidural ketamine. The symptoms related to dysfunction of the sympathetic nervous system still remained after complete pain relief. We discuss pain mechanisms, pain relief and the use of ketamine in this case.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9583776</pmid><doi>10.1016/S0304-3959(97)00189-9</doi><tpages>4</tpages></addata></record> |
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| ispartof | Pain (Amsterdam), 1998-04, Vol.75 (2), p.391-394 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Analgesics Biological and medical sciences Causalgia - physiopathology Complex regional pain syndrome Epidural administration Humans Injections, Epidural Ketamine Ketamine - administration & dosage Ketamine - therapeutic use Leg Male Medical sciences N-Methyl- d-aspartic acid receptor antagonist Neuropathic pain Neuropharmacology Pain - physiopathology Pharmacology. Drug treatments Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Sciatic Nerve - injuries Wounds and Injuries - physiopathology |
| title | The NMDA-receptor antagonist ketamine abolishes neuropathic pain after epidural administration in a clinical case |
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