Disruption of the RB pathway and cell‐proliferative activity in non‐small‐cell lung cancers

The pathway consisting of retinoblastoma protein (pRB), cyclin D1 and p16 (RB pathway) which is involved in the phosphorylation of pRB plays an important role in G1/S progression. The disruption of this RB pathway has been reported in several types of human neoplasm. An immunohistochemical study of...

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Veröffentlicht in:	International journal of cancer 1998-04, Vol.79 (2), p.111-115
Hauptverfasser:	Tanaka, Hisaichi, Fujii, Yoshitaka, Hirabayashi, Hirohisa, Miyoshi, Shinichiro, Sakaguchi, Masahiro, Yoon, Hyung‐Eun, Matsuda, Hikaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Biological and medical sciences Carcinoma, Large Cell - metabolism Carcinoma, Large Cell - pathology Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Cycle Cell Division Cyclin D1 - analysis Cyclin D1 - biosynthesis Cyclin-Dependent Kinase Inhibitor p16 - analysis Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis Female Humans Immunohistochemistry Ki-67 Antigen - analysis Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - surgery Male Medical sciences Neoplasm Staging Pneumology Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Retinoblastoma Protein - analysis Retinoblastoma Protein - biosynthesis Tumors of the respiratory system and mediastinum
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