Sensitization of the Mesoaccumbens Dopamine Response to Nicotine
This article reviews the evidence that pretreatment with nicotine causes a regionally selective sensitization of its stimulatory effects on a pathway, the mesoaccumbens dopamine (DA) system, which has been implicated in the locomotor stimulant response to nicotine and its ability to reinforce self-a...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1998-04, Vol.59 (4), p.1021-1030 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Balfour, David J.K Benwell, Maureen E.M Birrell, Claire E Kelly, J Al-Aloul, Mohamed |
| description | This article reviews the evidence that pretreatment with nicotine causes a regionally selective sensitization of its stimulatory effects on a pathway, the mesoaccumbens dopamine (DA) system, which has been implicated in the locomotor stimulant response to nicotine and its ability to reinforce self-administration. The sensitization evoked by daily injections of nicotine is associated with a regionally selective downregulation of the control of mesoaccumbens DA neurons by inhibitory autoreceptors and depends upon co-stimulation of NMDA glutamatergic receptors. It is suggested that the sensitization is related to enhanced burst firing of mesoaccumbens neurons, which results in an enhancement of DA release into the extracellular space between the cells where it acts upon putative extrasynaptic dopamine receptors. The studies with NMDA receptor antagonists revealed a dissociation between the expression of sensitized mesoaccumbens DA and locomotor responses to nicotine. It is proposed, therefore, that the sensitized mesoaccumbens DA responses to nicotine may be implicated in psychopharmacological responses to drug concerned more closely with nicotine dependence. |
| doi_str_mv | 10.1016/S0091-3057(97)00537-6 |
| format | Article |
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The sensitization evoked by daily injections of nicotine is associated with a regionally selective downregulation of the control of mesoaccumbens DA neurons by inhibitory autoreceptors and depends upon co-stimulation of NMDA glutamatergic receptors. It is suggested that the sensitization is related to enhanced burst firing of mesoaccumbens neurons, which results in an enhancement of DA release into the extracellular space between the cells where it acts upon putative extrasynaptic dopamine receptors. The studies with NMDA receptor antagonists revealed a dissociation between the expression of sensitized mesoaccumbens DA and locomotor responses to nicotine. 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The sensitization evoked by daily injections of nicotine is associated with a regionally selective downregulation of the control of mesoaccumbens DA neurons by inhibitory autoreceptors and depends upon co-stimulation of NMDA glutamatergic receptors. It is suggested that the sensitization is related to enhanced burst firing of mesoaccumbens neurons, which results in an enhancement of DA release into the extracellular space between the cells where it acts upon putative extrasynaptic dopamine receptors. The studies with NMDA receptor antagonists revealed a dissociation between the expression of sensitized mesoaccumbens DA and locomotor responses to nicotine. It is proposed, therefore, that the sensitized mesoaccumbens DA responses to nicotine may be implicated in psychopharmacological responses to drug concerned more closely with nicotine dependence.</description><subject>Animals</subject><subject>Dependence</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Uptake Inhibitors - pharmacology</subject><subject>Dorsolateral striatum</subject><subject>Humans</subject><subject>Locomotor activity</subject><subject>Nicotine - pharmacology</subject><subject>Nicotine<Dopamine</subject><subject>Nicotinic Agonists - pharmacology</subject><subject>NMDA</subject><subject>Nomifensine - pharmacology</subject><subject>Nucleus accumbens</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Raclopride</subject><subject>Receptors</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRaq3-hEJOoofobJLN7J5U6idUBavnJdlMcKXJ1mwi6K83_aDXngbmfd4ZeBgbc7jgwNPLGYDiYQwCzxSeA4gYw3SPDbnEOBQccZ8Nt8ghO_L-CwCSKMUBGyghU5nGQ3Y9o9rb1v5lrXV14Mqg_aTgmbzLjOmqvE-DW7fIKltT8EZ-4WpPQeuCF2tc2y-P2UGZzT2dbOaIfdzfvU8ew-nrw9PkZhoaAaoNS57KRFFWgFQykgWqDE2KcS4S4FAWvCxyUiJBQBXFOaEpOao4IVGQUqKMR-x0fXfRuO-OfKsr6w3N51lNrvMalUSeCLkT5BglKCLoQbEGTeO8b6jUi8ZWWfOrOeilYr1SrJf-tEK9UqzTvjfePOjyiopta-O0z6_WOfU6fiw12htLtaHCNmRaXTi748M_OlOKiQ</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Balfour, David J.K</creator><creator>Benwell, Maureen E.M</creator><creator>Birrell, Claire E</creator><creator>Kelly, J</creator><creator>Al-Aloul, Mohamed</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Sensitization of the Mesoaccumbens Dopamine Response to Nicotine</title><author>Balfour, David J.K ; Benwell, Maureen E.M ; Birrell, Claire E ; Kelly, J ; Al-Aloul, Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-f16849ead089828d79a7c673b54010fd1fdbe954707923be7cf17934e5de995f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Dependence</topic><topic>Dopamine - metabolism</topic><topic>Dopamine Uptake Inhibitors - pharmacology</topic><topic>Dorsolateral striatum</topic><topic>Humans</topic><topic>Locomotor activity</topic><topic>Nicotine - pharmacology</topic><topic>Nicotine<Dopamine</topic><topic>Nicotinic Agonists - pharmacology</topic><topic>NMDA</topic><topic>Nomifensine - pharmacology</topic><topic>Nucleus accumbens</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Raclopride</topic><topic>Receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balfour, David J.K</creatorcontrib><creatorcontrib>Benwell, Maureen E.M</creatorcontrib><creatorcontrib>Birrell, Claire E</creatorcontrib><creatorcontrib>Kelly, J</creatorcontrib><creatorcontrib>Al-Aloul, Mohamed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balfour, David J.K</au><au>Benwell, Maureen E.M</au><au>Birrell, Claire E</au><au>Kelly, J</au><au>Al-Aloul, Mohamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensitization of the Mesoaccumbens Dopamine Response to Nicotine</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>59</volume><issue>4</issue><spage>1021</spage><epage>1030</epage><pages>1021-1030</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><abstract>This article reviews the evidence that pretreatment with nicotine causes a regionally selective sensitization of its stimulatory effects on a pathway, the mesoaccumbens dopamine (DA) system, which has been implicated in the locomotor stimulant response to nicotine and its ability to reinforce self-administration. 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| ispartof | Pharmacology, biochemistry and behavior, 1998-04, Vol.59 (4), p.1021-1030 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Dependence Dopamine - metabolism Dopamine Uptake Inhibitors - pharmacology Dorsolateral striatum Humans Locomotor activity Nicotine - pharmacology Nicotine<Dopamine Nicotinic Agonists - pharmacology NMDA Nomifensine - pharmacology Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Raclopride Receptors |
| title | Sensitization of the Mesoaccumbens Dopamine Response to Nicotine |
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