The efficient expression of intravascularly delivered DNA in rat muscle

Previous studies have demonstrated that muscle can take up and express naked DNA or RNA. This study demonstrates that the pDNA can be delivered to and expressed within skeletal muscle when injected rapidly, in a large volume and when all blood vessels leading into and out of the hindlimb are occlude...

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Veröffentlicht in:	Gene therapy 1998-02, Vol.5 (2), p.272-276
Hauptverfasser:	BUDKER, V, ZHANG, G, DANKO, I, WILLIAMS, P, WOLFF, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Blood vessels Collagen Collagenase Collagenases - administration & dosage Deoxyribonucleic acid DNA DNA - administration & dosage Fundamental and applied biological sciences. Psychology Gene Expression Gene therapy Gene Transfer Techniques Genetic Therapy - methods Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Injections, Intramuscular Injections, Intravenous Ischemia Muscle, Skeletal - blood supply Muscle, Skeletal - metabolism Papaverine - administration & dosage Plasmids Rats Rats, Sprague-Dawley Skeletal muscle
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