Regulation of ductus arteriosus patency by nitric oxide in fetal lambs : The role of gestation, oxygen tension, and vasa vasorum

We hypothesized that nitric oxide (NO) production by the fetal ductus arteriosus is limited because of low fetal PO2, but that at neonatal PO2, NO might be an important regulator of ductus arteriosus tone. We exposed isolated rings of fetal lamb ductus arteriosus to elevated PO2. L-NG-nitro-L-argini...

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Veröffentlicht in:	Pediatric research 1998-05, Vol.43 (5), p.633-644
Hauptverfasser:	CLYMAN, R. I, WALEH, N, BLACK, S. M, RIEMER, R. K, MAURAY, F, CHEN, Y.-Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines - pharmacology Animals Aorta - drug effects Aorta - physiology Biological and medical sciences Calcimycin - pharmacology Diseases of mother, fetus and pregnancy Ductus Arteriosus - drug effects Ductus Arteriosus - embryology Ductus Arteriosus - physiology Ductus Arteriosus, Patent - embryology Ductus Arteriosus, Patent - physiopathology Enzyme Inhibitors - pharmacology Female Fetus Guanylate Cyclase - pharmacology Gynecology. Andrology. Obstetrics In Vitro Techniques Indomethacin - pharmacology Medical sciences Methylene Blue - pharmacology Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle Relaxation - physiology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - embryology Muscle, Smooth, Vascular - physiology NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - physiology Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Oxygen - blood Oxygen - pharmacology Partial Pressure Polymerase Chain Reaction Pregnancy Pregnancy. Fetus. Placenta Sheep Vasa Vasorum - drug effects Vasa Vasorum - physiology
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