Structure-Activity Relationships of Alkylxanthine Inhibitors of Phosphodiesterase IV Isoenzyme

The structural and electronic properties of seventeen alkylxanthine derivatives were calculated using the MO program PM3 to elucidate the key features related to their inhibitory activity on phosphodiesterase (PDE) IV isoenzyme. Except for 7-alkylxanthine derivatives, a good correlation could be est...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1998/04/15, Vol.21(4), pp.356-359
Hauptverfasser:	YAMAMOTO, Kenji, SAWANISHI, Hiroyuki, MIYAMOTO, Ken-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors alkylxanthine Biological and medical sciences Cyclic Nucleotide Phosphodiesterases, Type 4 Enzyme Inhibitors - pharmacology General pharmacology HOMO energy Isoenzymes - antagonists & inhibitors Medical sciences MO calclulation Models, Molecular PDE IV inhibition Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Structure-Activity Relationship Xanthines - chemistry Xanthines - pharmacology
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