Effect of Basic Fibroblast Growth Factor on Cholecystokinin-Induced Amylase Release and Intracellular Calcium Increase in Male Rat Pancreatic Acinar Cells

Isolated rat pancreatic acinar cells were used to investigate the effect of basic fibroblast growth factor (bFGF) on both amylase secretion and intracellular free calcium concentration ([Ca 2+] i) in response to the calcium-mobilizing secretagogue cholecystokinin-octapeptide (CCK-8). Our data show t...

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Veröffentlicht in:	Biochemical pharmacology 1998-03, Vol.55 (6), p.903-908
Hauptverfasser:	Lajas, Ana I, Pozo, Marı́a J, Salido, Ginés M, Pariente, Jose A
Format:	Artikel
Sprache:	eng
Schlagworte:	amylase secretion Amylases - metabolism Animals basic fibroblast growth factor Biological and medical sciences calcium Calcium - metabolism Cell physiology cholecystokinin Enzyme Inhibitors - pharmacology Fibroblast Growth Factor 2 - pharmacology Fundamental and applied biological sciences. Psychology Male Molecular and cellular biology Nitriles - pharmacology Pancreas - cytology Pancreas - drug effects Pancreas - metabolism pancreatic acinar cells Protein-Tyrosine Kinases - antagonists & inhibitors Rats Rats, Wistar Responses to growth factors, tumor promotors, other factors Sincalide - pharmacology tyrosine kinase Tyrphostins
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