Potent and highly selective neurokinin antagonists
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| Veröffentlicht in: | Journal of medicinal chemistry 1990-07, Vol.33 (7), p.1848-1851 |
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| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
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| container_end_page | 1851 |
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| container_issue | 7 |
| container_start_page | 1848 |
| container_title | Journal of medicinal chemistry |
| container_volume | 33 |
| creator | Ward, P Ewan, G. B Jordan, C. C Ireland, S. J Hagan, R. M Brown, J. R |
| description | |
| doi_str_mv | 10.1021/jm00169a003 |
| format | Article |
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Chem</addtitle><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Guinea Pigs</subject><subject>In Vitro Techniques</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestines - drug effects</subject><subject>Intestines - physiology</subject><subject>Molecular Sequence Data</subject><subject>Molecular Structure</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - metabolism</subject><subject>Muscle, Smooth - physiology</subject><subject>Neurokinin A - analogs & derivatives</subject><subject>Neurokinin A - antagonists & inhibitors</subject><subject>Neurokinin A - chemical synthesis</subject><subject>Neurokinin A - pharmacology</subject><subject>Neurokinin B - analogs & derivatives</subject><subject>Neurokinin B - antagonists & inhibitors</subject><subject>Neurokinin B - chemical synthesis</subject><subject>Neurokinin B - pharmacology</subject><subject>Protein Conformation</subject><subject>Rats</subject><subject>Receptors, Neurokinin-1</subject><subject>Receptors, Neurokinin-2</subject><subject>Receptors, Neurokinin-3</subject><subject>Receptors, Neurotransmitter - drug effects</subject><subject>Receptors, Neurotransmitter - metabolism</subject><subject>Structure-Activity Relationship</subject><subject>Substance P - analogs & derivatives</subject><subject>Substance P - antagonists & inhibitors</subject><subject>Substance P - chemical synthesis</subject><subject>Substance P - pharmacology</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkD1PwzAQQC0EKqUwMSNlggEFznbsJCOqKCAqqNQisVlOfGnT5gPiBNF_j1EqYGC64T3d6R4hpxSuKDB6vS4BqIw1AN8jQyoY-EEEwT4ZAjDmM8n4ITmydg3OoIwPyMDpgQjEkLBZ3WLVeroy3ipfroqtZ7HAtM0_0Kuwa-pNXuWV461e1lVuW3tMDjJdWDzZzRF5mdwuxvf-9PnuYXwz9TUXQetLaYIsBGFAgjQyTSgzLJWURyxCjgg6AEFj1MxETKPAJAox4JFJWCwzKvmInPd735r6vUPbqjK3KRaFrrDurArjSLJICCde9mLa1NY2mKm3Ji91s1UU1Hch9aeQs892a7ukRPPr9kkc93vufsXPH6ybjZIhD4VazObqKZw90nk8Ua_Ov-h9nVq1rrumclH-vfwF6JJ7gg</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Ward, P</creator><creator>Ewan, G. 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| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1990-07, Vol.33 (7), p.1848-1851 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79862855 |
| source | MEDLINE; American Chemical Society (ACS) Journals |
| subjects | Amino Acid Sequence Animals Guinea Pigs In Vitro Techniques Intestinal Mucosa - metabolism Intestines - drug effects Intestines - physiology Molecular Sequence Data Molecular Structure Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscle, Smooth - physiology Neurokinin A - analogs & derivatives Neurokinin A - antagonists & inhibitors Neurokinin A - chemical synthesis Neurokinin A - pharmacology Neurokinin B - analogs & derivatives Neurokinin B - antagonists & inhibitors Neurokinin B - chemical synthesis Neurokinin B - pharmacology Protein Conformation Rats Receptors, Neurokinin-1 Receptors, Neurokinin-2 Receptors, Neurokinin-3 Receptors, Neurotransmitter - drug effects Receptors, Neurotransmitter - metabolism Structure-Activity Relationship Substance P - analogs & derivatives Substance P - antagonists & inhibitors Substance P - chemical synthesis Substance P - pharmacology |
| title | Potent and highly selective neurokinin antagonists |
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