Effects of Codeine on the Agitating Force and Gastrointestinal Transit Time in Dogs, for Use in Drug Absorption Studies
Drug absorption studies using dogs have been difficult because of different gastrointestina(GI) conditions between dogs and humans, including dogs' shorter intestinal transit time and strong agitation force in the GI tract. We attempted to modify the agitation force and GI transit time in dogs...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 1998/04/15, Vol.21(4), pp.418-420 |
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| container_end_page | 420 |
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| container_title | Biological & pharmaceutical bulletin |
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| creator | KATORI, Noriko AOYAGI, Nobuo KOJIMA, Shigeo |
| description | Drug absorption studies using dogs have been difficult because of different gastrointestina(GI) conditions between dogs and humans, including dogs' shorter intestinal transit time and strong agitation force in the GI tract. We attempted to modify the agitation force and GI transit time in dogs using codeine. The agitation force was examined based on the in vitro/in vivo correlation for a CR tablet of acetaminophen showing agitation-dependant release. Codeine improved the GI condition better than atropine or loperamide, employed previously. |
| doi_str_mv | 10.1248/bpb.21.418 |
| format | Article |
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We attempted to modify the agitation force and GI transit time in dogs using codeine. The agitation force was examined based on the in vitro/in vivo correlation for a CR tablet of acetaminophen showing agitation-dependant release. Codeine improved the GI condition better than atropine or loperamide, employed previously.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.21.418</identifier><identifier>PMID: 9586586</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>acetaminophen ; Acetaminophen - pharmacology ; Analgesics ; Analgesics, Non-Narcotic - pharmacology ; Animals ; Biological and medical sciences ; codeine ; Codeine - pharmacology ; Dogs ; drug absorption ; Gastrointestinal Motility - drug effects ; Gastrointestinal Transit - drug effects ; gastrointestinal(GI) transit time ; hydrohynamic flow ; in vitro/in vivo relationship ; Intestinal Absorption - drug effects ; Male ; Medical sciences ; Narcotics - pharmacology ; Neuropharmacology ; Pharmacology. Drug treatments ; Time Factors</subject><ispartof>Biological and Pharmaceutical Bulletin, 1998/04/15, Vol.21(4), pp.418-420</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1998 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c627t-9e25212ed0dd17a1a4837285667190c0432fc7a09d486a93ee8a3b92ab267f9f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2319791$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9586586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KATORI, Noriko</creatorcontrib><creatorcontrib>AOYAGI, Nobuo</creatorcontrib><creatorcontrib>KOJIMA, Shigeo</creatorcontrib><title>Effects of Codeine on the Agitating Force and Gastrointestinal Transit Time in Dogs, for Use in Drug Absorption Studies</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Drug absorption studies using dogs have been difficult because of different gastrointestina(GI) conditions between dogs and humans, including dogs' shorter intestinal transit time and strong agitation force in the GI tract. We attempted to modify the agitation force and GI transit time in dogs using codeine. The agitation force was examined based on the in vitro/in vivo correlation for a CR tablet of acetaminophen showing agitation-dependant release. Codeine improved the GI condition better than atropine or loperamide, employed previously.</description><subject>acetaminophen</subject><subject>Acetaminophen - pharmacology</subject><subject>Analgesics</subject><subject>Analgesics, Non-Narcotic - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>codeine</subject><subject>Codeine - pharmacology</subject><subject>Dogs</subject><subject>drug absorption</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Gastrointestinal Transit - drug effects</subject><subject>gastrointestinal(GI) transit time</subject><subject>hydrohynamic flow</subject><subject>in vitro/in vivo relationship</subject><subject>Intestinal Absorption - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Narcotics - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Time Factors</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc2LFDEQxYMo67h68S4EFA9ij_noycdxGHdXYcGDs-eQTld6M_R0xiSN-N-btYc5CCGBvB_1quoh9JaSNWWt-tKdujWj65aqZ2hFeSubDaOb52hFNFWNoBv1Er3K-UAIkYTxK3SlN0rUs0K_b7wHVzKOHu9iD2ECHCdcHgFvh1BsCdOAb2NygO3U4zubS4phKpCrYke8T3bKoeB9OAIOE_4ah_wZ-5jwQ14-0jzgbZdjOpVQK_8scx8gv0YvvB0zvDm_1-jh9ma_-9bc_7j7vtveN04wWRoNrI7CoCd9T6WltlVcMrURQlJNHGk5805aovtWCas5gLK808x2TEivPb9GH5e6pxR_zbVrcwzZwTjaCeKcjdRKMEJ5Bd__Bx7inOqI2dC21VQKoUWlPi2USzHnBN6cUjja9MdQYp6yMDULw6ipWVT43bnk3B2hv6Dn5Vf9w1m32dnR11W6kC8Y41RLTSu2W7BDLnaAi25TCW6EJ0eqNf_nulzV_KK6R5sMTPwv9ken1A</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>KATORI, Noriko</creator><creator>AOYAGI, Nobuo</creator><creator>KOJIMA, Shigeo</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Effects of Codeine on the Agitating Force and Gastrointestinal Transit Time in Dogs, for Use in Drug Absorption Studies</title><author>KATORI, Noriko ; AOYAGI, Nobuo ; KOJIMA, Shigeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c627t-9e25212ed0dd17a1a4837285667190c0432fc7a09d486a93ee8a3b92ab267f9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>acetaminophen</topic><topic>Acetaminophen - pharmacology</topic><topic>Analgesics</topic><topic>Analgesics, Non-Narcotic - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>codeine</topic><topic>Codeine - pharmacology</topic><topic>Dogs</topic><topic>drug absorption</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Gastrointestinal Transit - drug effects</topic><topic>gastrointestinal(GI) transit time</topic><topic>hydrohynamic flow</topic><topic>in vitro/in vivo relationship</topic><topic>Intestinal Absorption - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Narcotics - pharmacology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KATORI, Noriko</creatorcontrib><creatorcontrib>AOYAGI, Nobuo</creatorcontrib><creatorcontrib>KOJIMA, Shigeo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KATORI, Noriko</au><au>AOYAGI, Nobuo</au><au>KOJIMA, Shigeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Codeine on the Agitating Force and Gastrointestinal Transit Time in Dogs, for Use in Drug Absorption Studies</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>21</volume><issue>4</issue><spage>418</spage><epage>420</epage><pages>418-420</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Drug absorption studies using dogs have been difficult because of different gastrointestina(GI) conditions between dogs and humans, including dogs' shorter intestinal transit time and strong agitation force in the GI tract. We attempted to modify the agitation force and GI transit time in dogs using codeine. The agitation force was examined based on the in vitro/in vivo correlation for a CR tablet of acetaminophen showing agitation-dependant release. Codeine improved the GI condition better than atropine or loperamide, employed previously.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>9586586</pmid><doi>10.1248/bpb.21.418</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 1998/04/15, Vol.21(4), pp.418-420 |
| issn | 0918-6158 1347-5215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79862013 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | acetaminophen Acetaminophen - pharmacology Analgesics Analgesics, Non-Narcotic - pharmacology Animals Biological and medical sciences codeine Codeine - pharmacology Dogs drug absorption Gastrointestinal Motility - drug effects Gastrointestinal Transit - drug effects gastrointestinal(GI) transit time hydrohynamic flow in vitro/in vivo relationship Intestinal Absorption - drug effects Male Medical sciences Narcotics - pharmacology Neuropharmacology Pharmacology. Drug treatments Time Factors |
| title | Effects of Codeine on the Agitating Force and Gastrointestinal Transit Time in Dogs, for Use in Drug Absorption Studies |
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