Effects of chronic non-ketotic diabetes and aging on myocardial function and fatty acid oxidation
The effects of aging and chronic non-ketotic diabetes on contractile properties, oxygen consumption, palmitate oxidation and morphology were studied in isolated, perfused working hearts of 2, 9, 12 and 22 month old rats. The heart rate, coronary flow, and oxygen consumption were no different among t...
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| Veröffentlicht in: | The Journal of diabetic complications 1990, Vol.4 (1), p.26-34 |
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| container_title | The Journal of diabetic complications |
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| creator | Murthy, Veeraraghavan K. Jameson, Mark Todd, Gordon L. Shipp, Joseph C. |
| description | The effects of aging and chronic non-ketotic diabetes on contractile properties, oxygen consumption, palmitate oxidation and morphology were studied in isolated, perfused working hearts of 2, 9, 12 and 22 month old rats. The heart rate, coronary flow, and oxygen consumption were no different among the 9, 12 and 22 month control and diabetic hearts. Cardiac work was not depressed in control hearts until 22 months of age. Depression of cardiac output due to aging in the control hearts progressed in stages. The superimposition of chronic diabetes in the 9, 12 and 22 month rats did not further depress the cardiac work or cardiac output. [1-
14C] palmitate oxidation in the 2 and 9 month control hearts was higher than that of the 12 and 22 month controls. Chronic diabetes did not affect fatty acid oxidation in the 9 and 12 month rats compared to their controls, but was diminished in the 22 month diabetic rat heart. These results suggest that impairments in the contractile properties of the isolated hearts of the chronically diabetic, senescent rats were primarily due to aging. |
| doi_str_mv | 10.1016/0891-6632(90)90061-9 |
| format | Article |
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14C] palmitate oxidation in the 2 and 9 month control hearts was higher than that of the 12 and 22 month controls. Chronic diabetes did not affect fatty acid oxidation in the 9 and 12 month rats compared to their controls, but was diminished in the 22 month diabetic rat heart. These results suggest that impairments in the contractile properties of the isolated hearts of the chronically diabetic, senescent rats were primarily due to aging.</description><identifier>ISSN: 0891-6632</identifier><identifier>DOI: 10.1016/0891-6632(90)90061-9</identifier><identifier>PMID: 2141842</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging ; Animals ; Body Weight ; Cardiac Output ; Coronary Circulation ; Diabetes Mellitus - pathology ; Diabetes Mellitus, Experimental - physiopathology ; Heart - growth & development ; Heart - physiology ; Heart - physiopathology ; Male ; Microscopy, Electron ; Myocardium - pathology ; Myocardium - ultrastructure ; Organ Size ; Oxidation-Reduction ; Oxygen Consumption ; Palmitic Acid ; Palmitic Acids - metabolism ; Rats ; Rats, Inbred Strains ; Reference Values ; Triglycerides - metabolism</subject><ispartof>The Journal of diabetic complications, 1990, Vol.4 (1), p.26-34</ispartof><rights>1990</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-78c92445f769726b53a379a4b788ea06620616fd02ec47f1c4caf71005489b453</citedby><cites>FETCH-LOGICAL-c272t-78c92445f769726b53a379a4b788ea06620616fd02ec47f1c4caf71005489b453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2141842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murthy, Veeraraghavan K.</creatorcontrib><creatorcontrib>Jameson, Mark</creatorcontrib><creatorcontrib>Todd, Gordon L.</creatorcontrib><creatorcontrib>Shipp, Joseph C.</creatorcontrib><title>Effects of chronic non-ketotic diabetes and aging on myocardial function and fatty acid oxidation</title><title>The Journal of diabetic complications</title><addtitle>J Diabet Complications</addtitle><description>The effects of aging and chronic non-ketotic diabetes on contractile properties, oxygen consumption, palmitate oxidation and morphology were studied in isolated, perfused working hearts of 2, 9, 12 and 22 month old rats. The heart rate, coronary flow, and oxygen consumption were no different among the 9, 12 and 22 month control and diabetic hearts. Cardiac work was not depressed in control hearts until 22 months of age. Depression of cardiac output due to aging in the control hearts progressed in stages. The superimposition of chronic diabetes in the 9, 12 and 22 month rats did not further depress the cardiac work or cardiac output. [1-
14C] palmitate oxidation in the 2 and 9 month control hearts was higher than that of the 12 and 22 month controls. Chronic diabetes did not affect fatty acid oxidation in the 9 and 12 month rats compared to their controls, but was diminished in the 22 month diabetic rat heart. These results suggest that impairments in the contractile properties of the isolated hearts of the chronically diabetic, senescent rats were primarily due to aging.</description><subject>Aging</subject><subject>Animals</subject><subject>Body Weight</subject><subject>Cardiac Output</subject><subject>Coronary Circulation</subject><subject>Diabetes Mellitus - pathology</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Heart - growth & development</subject><subject>Heart - physiology</subject><subject>Heart - physiopathology</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Myocardium - pathology</subject><subject>Myocardium - ultrastructure</subject><subject>Organ Size</subject><subject>Oxidation-Reduction</subject><subject>Oxygen Consumption</subject><subject>Palmitic Acid</subject><subject>Palmitic Acids - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reference Values</subject><subject>Triglycerides - metabolism</subject><issn>0891-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PAyEQxTloaq1-A004GT2sAqWwXExMU_8kTbzombAsVHQXKlBjv72sbTx6msm8NzN5PwDOMLrGCLMbVAtcMTYllwJdCYQYrsQBGP-Nj8BxSu8IkZoyPAIjgimuKRkDtbDW6JxgsFC_xeCdhj746sPkkEvfOtWYbBJUvoVq5fwKBg_7bdAqFq2DduN1dmU2GKzKeQuVdi0M365Vg3ACDq3qkjnd1wl4vV-8zB-r5fPD0_xuWWnCSa54rQWhdGY5E5ywZjZVUy4UbXhdG4UYIyUUsy0iRlNusaZaWY4RmtFaNHQ2nYCL3d11DJ8bk7LsXdKm65Q3YZMkFzXDiKBipDujjiGlaKxcR9eruJUYyYGmHLDJAZsUSP7SlKKsne_vb5retH9Le5RFv93ppoT8cibKpJ3x2rQuFsKyDe7_Bz8UoYVi</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Murthy, Veeraraghavan K.</creator><creator>Jameson, Mark</creator><creator>Todd, Gordon L.</creator><creator>Shipp, Joseph C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Effects of chronic non-ketotic diabetes and aging on myocardial function and fatty acid oxidation</title><author>Murthy, Veeraraghavan K. ; Jameson, Mark ; Todd, Gordon L. ; Shipp, Joseph C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-78c92445f769726b53a379a4b788ea06620616fd02ec47f1c4caf71005489b453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Body Weight</topic><topic>Cardiac Output</topic><topic>Coronary Circulation</topic><topic>Diabetes Mellitus - pathology</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Heart - growth & development</topic><topic>Heart - physiology</topic><topic>Heart - physiopathology</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Myocardium - pathology</topic><topic>Myocardium - ultrastructure</topic><topic>Organ Size</topic><topic>Oxidation-Reduction</topic><topic>Oxygen Consumption</topic><topic>Palmitic Acid</topic><topic>Palmitic Acids - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reference Values</topic><topic>Triglycerides - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Murthy, Veeraraghavan K.</creatorcontrib><creatorcontrib>Jameson, Mark</creatorcontrib><creatorcontrib>Todd, Gordon L.</creatorcontrib><creatorcontrib>Shipp, Joseph C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of diabetic complications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murthy, Veeraraghavan K.</au><au>Jameson, Mark</au><au>Todd, Gordon L.</au><au>Shipp, Joseph C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of chronic non-ketotic diabetes and aging on myocardial function and fatty acid oxidation</atitle><jtitle>The Journal of diabetic complications</jtitle><addtitle>J Diabet Complications</addtitle><date>1990</date><risdate>1990</risdate><volume>4</volume><issue>1</issue><spage>26</spage><epage>34</epage><pages>26-34</pages><issn>0891-6632</issn><abstract>The effects of aging and chronic non-ketotic diabetes on contractile properties, oxygen consumption, palmitate oxidation and morphology were studied in isolated, perfused working hearts of 2, 9, 12 and 22 month old rats. 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14C] palmitate oxidation in the 2 and 9 month control hearts was higher than that of the 12 and 22 month controls. Chronic diabetes did not affect fatty acid oxidation in the 9 and 12 month rats compared to their controls, but was diminished in the 22 month diabetic rat heart. These results suggest that impairments in the contractile properties of the isolated hearts of the chronically diabetic, senescent rats were primarily due to aging.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2141842</pmid><doi>10.1016/0891-6632(90)90061-9</doi><tpages>9</tpages></addata></record> |
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| ispartof | The Journal of diabetic complications, 1990, Vol.4 (1), p.26-34 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aging Animals Body Weight Cardiac Output Coronary Circulation Diabetes Mellitus - pathology Diabetes Mellitus, Experimental - physiopathology Heart - growth & development Heart - physiology Heart - physiopathology Male Microscopy, Electron Myocardium - pathology Myocardium - ultrastructure Organ Size Oxidation-Reduction Oxygen Consumption Palmitic Acid Palmitic Acids - metabolism Rats Rats, Inbred Strains Reference Values Triglycerides - metabolism |
| title | Effects of chronic non-ketotic diabetes and aging on myocardial function and fatty acid oxidation |
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