Water and urea transport in human erythrocytes infected with the malaria parasite Plasmodium falciparum
The permeability properties of the human red cell membrane to various solutes are altered by malarial infection. In the present work we show that the permeability of the red cell membrane to water is also affected by the intraerythrocytic growth of the malaria parasite Plasmodium falciparum, whereas...
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| Veröffentlicht in: | Molecular and biochemical parasitology 1990-05, Vol.40 (2), p.269-278 |
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| container_title | Molecular and biochemical parasitology |
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| creator | Zanner, Mary Ann Galey, William R. Scaletti, Joseph V. Brahm, Jesper Vander Jagt, David L. |
| description | The permeability properties of the human red cell membrane to various solutes are altered by malarial infection. In the present work we show that the permeability of the red cell membrane to water is also affected by the intraerythrocytic growth of the malaria parasite
Plasmodium falciparum, whereas urea permeability appears unchanged. The data from infected cells show decreases in membrane surface area, cell volume, the osmotically active water fraction (
W
eff), and osmotic water permeability (
P
f) as measured by stopped-flow spectroscopy. On the other hand, the data suggest an increase in diffusive water permeability (
P
d) in infected cells with no change in urea permeability when measured by the continuous flow method. The decreased
P
f
P
d
ratio of infected cell membranes and its implications in the geometry of the red cell membrane water channel or pore are discussed. |
| doi_str_mv | 10.1016/0166-6851(90)90048-Q |
| format | Article |
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Plasmodium falciparum, whereas urea permeability appears unchanged. The data from infected cells show decreases in membrane surface area, cell volume, the osmotically active water fraction (
W
eff), and osmotic water permeability (
P
f) as measured by stopped-flow spectroscopy. On the other hand, the data suggest an increase in diffusive water permeability (
P
d) in infected cells with no change in urea permeability when measured by the continuous flow method. The decreased
P
f
P
d
ratio of infected cell membranes and its implications in the geometry of the red cell membrane water channel or pore are discussed.</description><identifier>ISSN: 0166-6851</identifier><identifier>EISSN: 1872-9428</identifier><identifier>DOI: 10.1016/0166-6851(90)90048-Q</identifier><identifier>PMID: 2194124</identifier><identifier>CODEN: MBIPDP</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Cell Membrane Permeability ; Erythrocyte Membrane - metabolism ; Erythrocyte Membrane - parasitology ; Erythrocyte Membrane - ultrastructure ; Fundamental and applied biological sciences. Psychology ; Humans ; Life cycle. Host-agent relationship. Pathogenesis ; Malaria - metabolism ; Microscopy, Electron, Scanning ; Osmosis ; Plasmodium falciparum ; Plasmodium falciparum - growth & development ; Plasmodium falciparum - ultrastructure ; Protozoa ; Red cell membrane ; Urea - blood ; Urea permeability ; Water - metabolism ; Water permeability</subject><ispartof>Molecular and biochemical parasitology, 1990-05, Vol.40 (2), p.269-278</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348q-7680c8e03d1c7c98001af139f07fc346f1b0ae6730b2d983655396efa845e80d3</citedby><cites>FETCH-LOGICAL-c348q-7680c8e03d1c7c98001af139f07fc346f1b0ae6730b2d983655396efa845e80d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0166-6851(90)90048-Q$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19715368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2194124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zanner, Mary Ann</creatorcontrib><creatorcontrib>Galey, William R.</creatorcontrib><creatorcontrib>Scaletti, Joseph V.</creatorcontrib><creatorcontrib>Brahm, Jesper</creatorcontrib><creatorcontrib>Vander Jagt, David L.</creatorcontrib><title>Water and urea transport in human erythrocytes infected with the malaria parasite Plasmodium falciparum</title><title>Molecular and biochemical parasitology</title><addtitle>Mol Biochem Parasitol</addtitle><description>The permeability properties of the human red cell membrane to various solutes are altered by malarial infection. In the present work we show that the permeability of the red cell membrane to water is also affected by the intraerythrocytic growth of the malaria parasite
Plasmodium falciparum, whereas urea permeability appears unchanged. The data from infected cells show decreases in membrane surface area, cell volume, the osmotically active water fraction (
W
eff), and osmotic water permeability (
P
f) as measured by stopped-flow spectroscopy. On the other hand, the data suggest an increase in diffusive water permeability (
P
d) in infected cells with no change in urea permeability when measured by the continuous flow method. The decreased
P
f
P
d
ratio of infected cell membranes and its implications in the geometry of the red cell membrane water channel or pore are discussed.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane Permeability</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Erythrocyte Membrane - parasitology</subject><subject>Erythrocyte Membrane - ultrastructure</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Life cycle. Host-agent relationship. Pathogenesis</subject><subject>Malaria - metabolism</subject><subject>Microscopy, Electron, Scanning</subject><subject>Osmosis</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - growth & development</subject><subject>Plasmodium falciparum - ultrastructure</subject><subject>Protozoa</subject><subject>Red cell membrane</subject><subject>Urea - blood</subject><subject>Urea permeability</subject><subject>Water - metabolism</subject><subject>Water permeability</subject><issn>0166-6851</issn><issn>1872-9428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rVDEUhoModVr9BwrZKHVx68n9yE02BSl-QUEListwJjlxIvdjmuRW5t834wztzkUIyfucl8PD2CsBFwKEfF-OrKTqxLmGdxqgVdXNE7YSqq8r3dbqKVs9IM_ZaUp_AKDrpTxhJ7XQrajbFfv9CzNFjpPjSyTkOeKUtnPMPEx8s4w4cYq7vImz3WVK5deTzeT435A3PG-IjzhgDMi3GDGFTPz7gGmcXVhG7nGwoQTL-II9K49EL4_3Gfv56eOPqy_V9bfPX68-XFe2adVt1UsFVhE0TtjeagUg0ItGe-h9IaQXa0CSfQPr2mnVyK5rtCSPqu1IgWvO2NtD7zbOtwulbMaQLA0DTjQvyfRaSag7KGB7AG2cU4rkzTaGEePOCDB7v2Yvz-zlGQ3mn19zU8ZeH_uX9UjuYegotORvjjkmi4MvOm1Ij926F10jVeEuDxwVGXeBokk20GTJhVgEGzeH_y9yDznImAg</recordid><startdate>199005</startdate><enddate>199005</enddate><creator>Zanner, Mary Ann</creator><creator>Galey, William R.</creator><creator>Scaletti, Joseph V.</creator><creator>Brahm, Jesper</creator><creator>Vander Jagt, David L.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199005</creationdate><title>Water and urea transport in human erythrocytes infected with the malaria parasite Plasmodium falciparum</title><author>Zanner, Mary Ann ; Galey, William R. ; Scaletti, Joseph V. ; Brahm, Jesper ; Vander Jagt, David L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348q-7680c8e03d1c7c98001af139f07fc346f1b0ae6730b2d983655396efa845e80d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Membrane Permeability</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Erythrocyte Membrane - parasitology</topic><topic>Erythrocyte Membrane - ultrastructure</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Life cycle. Host-agent relationship. Pathogenesis</topic><topic>Malaria - metabolism</topic><topic>Microscopy, Electron, Scanning</topic><topic>Osmosis</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - growth & development</topic><topic>Plasmodium falciparum - ultrastructure</topic><topic>Protozoa</topic><topic>Red cell membrane</topic><topic>Urea - blood</topic><topic>Urea permeability</topic><topic>Water - metabolism</topic><topic>Water permeability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zanner, Mary Ann</creatorcontrib><creatorcontrib>Galey, William R.</creatorcontrib><creatorcontrib>Scaletti, Joseph V.</creatorcontrib><creatorcontrib>Brahm, Jesper</creatorcontrib><creatorcontrib>Vander Jagt, David L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and biochemical parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zanner, Mary Ann</au><au>Galey, William R.</au><au>Scaletti, Joseph V.</au><au>Brahm, Jesper</au><au>Vander Jagt, David L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Water and urea transport in human erythrocytes infected with the malaria parasite Plasmodium falciparum</atitle><jtitle>Molecular and biochemical parasitology</jtitle><addtitle>Mol Biochem Parasitol</addtitle><date>1990-05</date><risdate>1990</risdate><volume>40</volume><issue>2</issue><spage>269</spage><epage>278</epage><pages>269-278</pages><issn>0166-6851</issn><eissn>1872-9428</eissn><coden>MBIPDP</coden><abstract>The permeability properties of the human red cell membrane to various solutes are altered by malarial infection. In the present work we show that the permeability of the red cell membrane to water is also affected by the intraerythrocytic growth of the malaria parasite
Plasmodium falciparum, whereas urea permeability appears unchanged. The data from infected cells show decreases in membrane surface area, cell volume, the osmotically active water fraction (
W
eff), and osmotic water permeability (
P
f) as measured by stopped-flow spectroscopy. On the other hand, the data suggest an increase in diffusive water permeability (
P
d) in infected cells with no change in urea permeability when measured by the continuous flow method. The decreased
P
f
P
d
ratio of infected cell membranes and its implications in the geometry of the red cell membrane water channel or pore are discussed.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>2194124</pmid><doi>10.1016/0166-6851(90)90048-Q</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular and biochemical parasitology, 1990-05, Vol.40 (2), p.269-278 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Cell Membrane Permeability Erythrocyte Membrane - metabolism Erythrocyte Membrane - parasitology Erythrocyte Membrane - ultrastructure Fundamental and applied biological sciences. Psychology Humans Life cycle. Host-agent relationship. Pathogenesis Malaria - metabolism Microscopy, Electron, Scanning Osmosis Plasmodium falciparum Plasmodium falciparum - growth & development Plasmodium falciparum - ultrastructure Protozoa Red cell membrane Urea - blood Urea permeability Water - metabolism Water permeability |
| title | Water and urea transport in human erythrocytes infected with the malaria parasite Plasmodium falciparum |
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