Naloxone-reversible analgesia produced by microstimulation of the arcuate nucleus of the hypothalamus in pentobarbital-anesthetized rats
Suppression of the tail flick response to noxious heat and paw withdrawal response to noxious pressure were produced by electrical stimulation of arcuate nucleus of the hypothalamus (ARH) in pentobarbital anesthetized rats. Systemic administration of naloxone (2 mg/kg) greatly antagonized the ARH st...
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| Veröffentlicht in: | Experimental brain research 1990-01, Vol.80 (1), p.201-204 |
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| creator | WANG, Q MAO, L. M HAN, J. S |
| description | Suppression of the tail flick response to noxious heat and paw withdrawal response to noxious pressure were produced by electrical stimulation of arcuate nucleus of the hypothalamus (ARH) in pentobarbital anesthetized rats. Systemic administration of naloxone (2 mg/kg) greatly antagonized the ARH stimulation-produced inhibition of both algesic reflexes. The thresholds of stimulation for inhibition of two spinal nociceptive reflexes in the lightly anesthetized state were not significantly different from the thresholds of stimulation at the same ARH sites in the awake state in the same animals. These findings provide evidence establishing the (1) usefulness of the anesthetized rat model for investigation of antinociceptive mechanisms; (2) the involvement of endogenous opioid mechanisms in mediating ARH stimulation-produced analgesia. |
| doi_str_mv | 10.1007/BF00228862 |
| format | Article |
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These findings provide evidence establishing the (1) usefulness of the anesthetized rat model for investigation of antinociceptive mechanisms; (2) the involvement of endogenous opioid mechanisms in mediating ARH stimulation-produced analgesia.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/BF00228862</identifier><identifier>PMID: 2358028</identifier><identifier>CODEN: EXBRAP</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Analgesia ; Anesthesia ; Animals ; Arcuate Nucleus of Hypothalamus - drug effects ; Arcuate Nucleus of Hypothalamus - physiology ; Biological and medical sciences ; Electric Stimulation ; Endorphins - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Naloxone - pharmacology ; Pentobarbital ; Rats ; Rats, Inbred Strains ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. 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S</creatorcontrib><title>Naloxone-reversible analgesia produced by microstimulation of the arcuate nucleus of the hypothalamus in pentobarbital-anesthetized rats</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><description>Suppression of the tail flick response to noxious heat and paw withdrawal response to noxious pressure were produced by electrical stimulation of arcuate nucleus of the hypothalamus (ARH) in pentobarbital anesthetized rats. Systemic administration of naloxone (2 mg/kg) greatly antagonized the ARH stimulation-produced inhibition of both algesic reflexes. The thresholds of stimulation for inhibition of two spinal nociceptive reflexes in the lightly anesthetized state were not significantly different from the thresholds of stimulation at the same ARH sites in the awake state in the same animals. These findings provide evidence establishing the (1) usefulness of the anesthetized rat model for investigation of antinociceptive mechanisms; (2) the involvement of endogenous opioid mechanisms in mediating ARH stimulation-produced analgesia.</description><subject>Analgesia</subject><subject>Anesthesia</subject><subject>Animals</subject><subject>Arcuate Nucleus of Hypothalamus - drug effects</subject><subject>Arcuate Nucleus of Hypothalamus - physiology</subject><subject>Biological and medical sciences</subject><subject>Electric Stimulation</subject><subject>Endorphins - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Naloxone - pharmacology</subject><subject>Pentobarbital</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS1EVbaFC3ekHBCHSgH_j3OkFYVKFVzgHE2cMWvkxIvtIJZP0I-NV13KsafRzPvpaWYeIS8Zfcso7d5dXlPKuTGaPyEbJgVvGaP6KdlQymQrDeufkbOcfxxa0dFTcsqFMpSbDbn7DCH-jgu2CX9hyn4M2MAC4TtmD80uxWm1ODXjvpm9TTEXP68Bio9LE11TtpVOdoWCzbLagGv-N97ud7FsIcBcZ35pdriUOEIafYHQwoK5UsX_qeYJSn5OThyEjC-O9Zx8u_7w9epTe_vl483V-9vWCslLOznslOSKdzhKYyU4JZSeJOhJI7Wqt_UhwhkqR-dYr0E6aTqnmehHxK4X5-TNvW897edalxhmny2GUDeKax663mhKBX8UZEp3RhlWwYt78PCenNANu-RnSPuB0eGQz_A_nwq_Orqu44zTA3oMpOqvjzpkC8ElWKzPD5juqyFX4i-2appT</recordid><startdate>19900101</startdate><enddate>19900101</enddate><creator>WANG, Q</creator><creator>MAO, L. M</creator><creator>HAN, J. S</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19900101</creationdate><title>Naloxone-reversible analgesia produced by microstimulation of the arcuate nucleus of the hypothalamus in pentobarbital-anesthetized rats</title><author>WANG, Q ; MAO, L. M ; HAN, J. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-dfe7542527eb48c4af5356d4a6d6e0c59c0073f804bff196a4f487f6139bee793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Analgesia</topic><topic>Anesthesia</topic><topic>Animals</topic><topic>Arcuate Nucleus of Hypothalamus - drug effects</topic><topic>Arcuate Nucleus of Hypothalamus - physiology</topic><topic>Biological and medical sciences</topic><topic>Electric Stimulation</topic><topic>Endorphins - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Naloxone - pharmacology</topic><topic>Pentobarbital</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WANG, Q</creatorcontrib><creatorcontrib>MAO, L. M</creatorcontrib><creatorcontrib>HAN, J. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WANG, Q</au><au>MAO, L. M</au><au>HAN, J. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Naloxone-reversible analgesia produced by microstimulation of the arcuate nucleus of the hypothalamus in pentobarbital-anesthetized rats</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>1990-01-01</date><risdate>1990</risdate><volume>80</volume><issue>1</issue><spage>201</spage><epage>204</epage><pages>201-204</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>Suppression of the tail flick response to noxious heat and paw withdrawal response to noxious pressure were produced by electrical stimulation of arcuate nucleus of the hypothalamus (ARH) in pentobarbital anesthetized rats. Systemic administration of naloxone (2 mg/kg) greatly antagonized the ARH stimulation-produced inhibition of both algesic reflexes. The thresholds of stimulation for inhibition of two spinal nociceptive reflexes in the lightly anesthetized state were not significantly different from the thresholds of stimulation at the same ARH sites in the awake state in the same animals. These findings provide evidence establishing the (1) usefulness of the anesthetized rat model for investigation of antinociceptive mechanisms; (2) the involvement of endogenous opioid mechanisms in mediating ARH stimulation-produced analgesia.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2358028</pmid><doi>10.1007/BF00228862</doi><tpages>4</tpages></addata></record> |
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| ispartof | Experimental brain research, 1990-01, Vol.80 (1), p.201-204 |
| issn | 0014-4819 1432-1106 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Analgesia Anesthesia Animals Arcuate Nucleus of Hypothalamus - drug effects Arcuate Nucleus of Hypothalamus - physiology Biological and medical sciences Electric Stimulation Endorphins - physiology Female Fundamental and applied biological sciences. Psychology Naloxone - pharmacology Pentobarbital Rats Rats, Inbred Strains Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs |
| title | Naloxone-reversible analgesia produced by microstimulation of the arcuate nucleus of the hypothalamus in pentobarbital-anesthetized rats |
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