N-methyl-D-aspartate-evoked calcium uptake by kitten visual cortex maintained in vitro
As a functional measure of NMDA receptor effectiveness in kitten striate cortex, the uptake of 45Ca by visual cortical slices was measured after 2 minute bath applications of N-methyl-D-aspartate (NMDA). Significant Ca uptake occurred in response to 12.5-100 microM NMDA in slices prepared from visua...
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| Veröffentlicht in: | Experimental brain research 1990, Vol.80 (2), p.252-259 |
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| creator | FELDMAN, D SHERIN, J. E PRESS, W. A BEAR, M. F |
| description | As a functional measure of NMDA receptor effectiveness in kitten striate cortex, the uptake of 45Ca by visual cortical slices was measured after 2 minute bath applications of N-methyl-D-aspartate (NMDA). Significant Ca uptake occurred in response to 12.5-100 microM NMDA in slices prepared from visual cortex of normal animals aged 28-48 days. Basal uptake (in the absence of NMDA) was increased and evoked uptake was decreased in visual cortical slices prepared from age-matched dark-reared animals. Four days of binocular deprivation in otherwise normally reared animals had no effect on basal uptake, but significantly lowered NMDA-evoked Ca uptake at agonist concentrations greater than 25 microM. These data suggest that even brief manipulations of sensory experience are sufficient to alter visual cortical calcium regulation. |
| doi_str_mv | 10.1007/BF00228153 |
| format | Article |
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E</creatorcontrib><creatorcontrib>PRESS, W. A</creatorcontrib><creatorcontrib>BEAR, M. F</creatorcontrib><title>N-methyl-D-aspartate-evoked calcium uptake by kitten visual cortex maintained in vitro</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><description>As a functional measure of NMDA receptor effectiveness in kitten striate cortex, the uptake of 45Ca by visual cortical slices was measured after 2 minute bath applications of N-methyl-D-aspartate (NMDA). Significant Ca uptake occurred in response to 12.5-100 microM NMDA in slices prepared from visual cortex of normal animals aged 28-48 days. Basal uptake (in the absence of NMDA) was increased and evoked uptake was decreased in visual cortical slices prepared from age-matched dark-reared animals. Four days of binocular deprivation in otherwise normally reared animals had no effect on basal uptake, but significantly lowered NMDA-evoked Ca uptake at agonist concentrations greater than 25 microM. These data suggest that even brief manipulations of sensory experience are sufficient to alter visual cortical calcium regulation.</description><subject>Animals</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Calcium - pharmacokinetics</subject><subject>Cats</subject><subject>Darkness</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Functional Laterality - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>N-Methylaspartate</subject><subject>Potassium - pharmacology</subject><subject>Receptors, N-Methyl-D-Aspartate</subject><subject>Receptors, Neurotransmitter - drug effects</subject><subject>Receptors, Neurotransmitter - physiology</subject><subject>Sensory Deprivation</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Visual Cortex - drug effects</subject><subject>Visual Cortex - metabolism</subject><subject>Visual Cortex - physiology</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1L5EAQhhtx0dH14l3IQTwIvVvVnf7IUcdPkPWy6zV0OhWMk0zG7o44_34zOOjRQ1EU71MF9TB2jPALAczvyxsAISwqucNmmEvBEUHvshkA5jy3WOyzgxhfNqM0sMf2BGphLMzY0x_eU3ped_yKu7hyIblEnN6GBdWZd51vxz4bV8ktKKvW2aJNiZbZWxtH12V-CInes961yzTVtNFushSGn-xH47pIR9t-yP7dXP-d3_GHx9v7-cUD90KZxEnX4LSzKGpskJS3UmJVW1_lVaNIFcJUuW-scRVKkgUIMCQJUFmopnflITv7uLsKw-tIMZV9Gz11nVvSMMbSFFYVCPZbEJW2oI2awPMP0IchxkBNuQpt78K6RCg3tssv2xN8sr06Vj3Vn-hW75SfbnMXJ5lNcEvfxk9MF6A1SvkfsFSF5Q</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>FELDMAN, D</creator><creator>SHERIN, J. 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Psychology</topic><topic>In Vitro Techniques</topic><topic>N-Methylaspartate</topic><topic>Potassium - pharmacology</topic><topic>Receptors, N-Methyl-D-Aspartate</topic><topic>Receptors, Neurotransmitter - drug effects</topic><topic>Receptors, Neurotransmitter - physiology</topic><topic>Sensory Deprivation</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Visual Cortex - drug effects</topic><topic>Visual Cortex - metabolism</topic><topic>Visual Cortex - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FELDMAN, D</creatorcontrib><creatorcontrib>SHERIN, J. E</creatorcontrib><creatorcontrib>PRESS, W. A</creatorcontrib><creatorcontrib>BEAR, M. 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F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-methyl-D-aspartate-evoked calcium uptake by kitten visual cortex maintained in vitro</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>1990</date><risdate>1990</risdate><volume>80</volume><issue>2</issue><spage>252</spage><epage>259</epage><pages>252-259</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>As a functional measure of NMDA receptor effectiveness in kitten striate cortex, the uptake of 45Ca by visual cortical slices was measured after 2 minute bath applications of N-methyl-D-aspartate (NMDA). Significant Ca uptake occurred in response to 12.5-100 microM NMDA in slices prepared from visual cortex of normal animals aged 28-48 days. Basal uptake (in the absence of NMDA) was increased and evoked uptake was decreased in visual cortical slices prepared from age-matched dark-reared animals. Four days of binocular deprivation in otherwise normally reared animals had no effect on basal uptake, but significantly lowered NMDA-evoked Ca uptake at agonist concentrations greater than 25 microM. These data suggest that even brief manipulations of sensory experience are sufficient to alter visual cortical calcium regulation.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2162780</pmid><doi>10.1007/BF00228153</doi><tpages>8</tpages></addata></record> |
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| ispartof | Experimental brain research, 1990, Vol.80 (2), p.252-259 |
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| language | eng |
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| subjects | Animals Aspartic Acid - analogs & derivatives Aspartic Acid - pharmacology Biological and medical sciences Calcium - pharmacokinetics Cats Darkness Eye and associated structures. Visual pathways and centers. Vision Functional Laterality - physiology Fundamental and applied biological sciences. Psychology In Vitro Techniques N-Methylaspartate Potassium - pharmacology Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - drug effects Receptors, Neurotransmitter - physiology Sensory Deprivation Vertebrates: nervous system and sense organs Visual Cortex - drug effects Visual Cortex - metabolism Visual Cortex - physiology |
| title | N-methyl-D-aspartate-evoked calcium uptake by kitten visual cortex maintained in vitro |
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