HER-2/neu amplification predicts poor survival in node-positive breast cancer

HER-2/neu protooncogene amplification and protein expression were analyzed with slot blot and Western blot techniques, respectively, in more than 300 invasive primary breast tumors of all stages. Amplification (2- greater than 30 copies) was found in 17% of these tumors and high expression was seen...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1990-07, Vol.50 (14), p.4332-4337
Hauptverfasser:	BORG, A, TANDON, A. K, SIGURDSSON, H, CLARK, G. M, FERNO, M, FUQUA, S. A. W, KILLANDER, D, MCGUIRE, W. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological and medical sciences Biomarkers, Tumor - analysis Blotting, Western breast Breast Neoplasms - analysis Breast Neoplasms - genetics Breast Neoplasms - pathology carcinoma Female Gene Amplification Gene Expression Gynecology. Andrology. Obstetrics Humans Immune Sera Lymphatic Metastasis Mammary gland diseases Medical sciences Menopause Molecular Sequence Data Peptides - chemical synthesis Peptides - immunology Prognosis Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - genetics Proto-Oncogenes Receptor, ErbB-2 Receptors, Estrogen - analysis Receptors, Progesterone Tumors
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