Small cell lung cancer presenting as a solitary pulmonary nodule
Small cell lung cancer (SCLC) rarely presents radiographically as a solitary pulmonary nodule (SPN). Twenty‐five patients with this feature were identified among 408 individuals with SCLC at McGill University (Montreal, Quebec) from 1979 through 1984. Of these, 15 (60%) were confirmed on pathologic...
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| Veröffentlicht in: | Cancer 1990-08, Vol.66 (3), p.577-582 |
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| creator | Quoix, Elisabeth Fraser, Richard Wolkove, Norman Finkelstein, Harriet Kreisman, Harvey |
| description | Small cell lung cancer (SCLC) rarely presents radiographically as a solitary pulmonary nodule (SPN). Twenty‐five patients with this feature were identified among 408 individuals with SCLC at McGill University (Montreal, Quebec) from 1979 through 1984. Of these, 15 (60%) were confirmed on pathologic review as SCLC (ten intermediate cell, four oat cell, one indeterminate). Pathologic review of a control group comprising 24 other limited‐disease patients who were long‐term survivors (> 20 months) confirmed 20 (84%) as SCLC (eight intermediate cell, 12 oat cell). Ten of the 15 patients with SPN were resected whereas five had chemotherapy and/or radiotherapy as primary treatment. Postoperative chemotherapy was administered to most of the resected patients. The median survival of the 15 patients with SPN was 24 months, a significantly longer survival than the other patients with SCLC. This improved prognosis in patients with SPN may be due to smaller initial tumor burden or to a fundamental biologic difference between SPN and other forms of SCLC. |
| doi_str_mv | 10.1002/1097-0142(19900801)66:3<577::AID-CNCR2820660328>3.0.CO;2-Y |
| format | Article |
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Twenty‐five patients with this feature were identified among 408 individuals with SCLC at McGill University (Montreal, Quebec) from 1979 through 1984. Of these, 15 (60%) were confirmed on pathologic review as SCLC (ten intermediate cell, four oat cell, one indeterminate). Pathologic review of a control group comprising 24 other limited‐disease patients who were long‐term survivors (> 20 months) confirmed 20 (84%) as SCLC (eight intermediate cell, 12 oat cell). Ten of the 15 patients with SPN were resected whereas five had chemotherapy and/or radiotherapy as primary treatment. Postoperative chemotherapy was administered to most of the resected patients. The median survival of the 15 patients with SPN was 24 months, a significantly longer survival than the other patients with SCLC. This improved prognosis in patients with SPN may be due to smaller initial tumor burden or to a fundamental biologic difference between SPN and other forms of SCLC.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19900801)66:3<577::AID-CNCR2820660328>3.0.CO;2-Y</identifier><identifier>PMID: 2163746</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Actuarial Analysis ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Small Cell - mortality ; Carcinoma, Small Cell - pathology ; Carcinoma, Small Cell - radiotherapy ; Carcinoma, Small Cell - surgery ; Female ; Humans ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Lung Neoplasms - radiotherapy ; Lung Neoplasms - surgery ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Solitary Pulmonary Nodule - mortality ; Solitary Pulmonary Nodule - pathology ; Solitary Pulmonary Nodule - radiotherapy ; Solitary Pulmonary Nodule - surgery ; Tumors of the respiratory system and mediastinum</subject><ispartof>Cancer, 1990-08, Vol.66 (3), p.577-582</ispartof><rights>Copyright © 1990 American Cancer Society</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4138-7a960ae52338167d09e0840adc7d51bd4b96795b204bf850f7d821c15391b0c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19596873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2163746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quoix, Elisabeth</creatorcontrib><creatorcontrib>Fraser, Richard</creatorcontrib><creatorcontrib>Wolkove, Norman</creatorcontrib><creatorcontrib>Finkelstein, Harriet</creatorcontrib><creatorcontrib>Kreisman, Harvey</creatorcontrib><title>Small cell lung cancer presenting as a solitary pulmonary nodule</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Small cell lung cancer (SCLC) rarely presents radiographically as a solitary pulmonary nodule (SPN). Twenty‐five patients with this feature were identified among 408 individuals with SCLC at McGill University (Montreal, Quebec) from 1979 through 1984. Of these, 15 (60%) were confirmed on pathologic review as SCLC (ten intermediate cell, four oat cell, one indeterminate). Pathologic review of a control group comprising 24 other limited‐disease patients who were long‐term survivors (> 20 months) confirmed 20 (84%) as SCLC (eight intermediate cell, 12 oat cell). Ten of the 15 patients with SPN were resected whereas five had chemotherapy and/or radiotherapy as primary treatment. Postoperative chemotherapy was administered to most of the resected patients. The median survival of the 15 patients with SPN was 24 months, a significantly longer survival than the other patients with SCLC. This improved prognosis in patients with SPN may be due to smaller initial tumor burden or to a fundamental biologic difference between SPN and other forms of SCLC.</description><subject>Actuarial Analysis</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Small Cell - mortality</subject><subject>Carcinoma, Small Cell - pathology</subject><subject>Carcinoma, Small Cell - radiotherapy</subject><subject>Carcinoma, Small Cell - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Solitary Pulmonary Nodule - mortality</subject><subject>Solitary Pulmonary Nodule - pathology</subject><subject>Solitary Pulmonary Nodule - radiotherapy</subject><subject>Solitary Pulmonary Nodule - surgery</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF2L1DAUhoO4rOPoTxB6o6wXHU-S5muUxbWuurA44Ae43hzSNJUuaTs2U2T_vSkzruiF4E2-3pyXh4eQVxRWFIA9o2BUDrRgJ9QYAA30qZRr_kIotV6fXbzOy_flB6YZSAmc6VO-glW5ec7yqztkcTt8lywgDeei4F_ukfsxXqerYoIfk2NGJVeFXJCXHzsbQuZ8WsLUf8uc7Z0fs-3oo-93bXqxMbNZHEK7s-NNtp1CN_TzqR_qKfgH5KixIfqHh31JPr85_1S-yy83by_Ks8vcFZTrXFkjwXrBONdUqhqMB12ArZ2qBa3qojJSGVExKKpGC2hUrRl1VHBDK3AFX5In-97tOHyffNxh18YZ2_Z-mCIqo4Wa65fk6_6jG4cYR9_gdmy7BIwUcNaLsyGcDeEvvSglckx6EZNe_FNvSgDLDTK8SuWPDhRT1fn6tvrgM-WPD7mNzoZmTDbb-JvACCO1miH9_t-PNvib_yL8J-BfCf8JqKyjKA</recordid><startdate>19900801</startdate><enddate>19900801</enddate><creator>Quoix, Elisabeth</creator><creator>Fraser, Richard</creator><creator>Wolkove, Norman</creator><creator>Finkelstein, Harriet</creator><creator>Kreisman, Harvey</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900801</creationdate><title>Small cell lung cancer presenting as a solitary pulmonary nodule</title><author>Quoix, Elisabeth ; Fraser, Richard ; Wolkove, Norman ; Finkelstein, Harriet ; Kreisman, Harvey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4138-7a960ae52338167d09e0840adc7d51bd4b96795b204bf850f7d821c15391b0c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Actuarial Analysis</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Small Cell - mortality</topic><topic>Carcinoma, Small Cell - pathology</topic><topic>Carcinoma, Small Cell - radiotherapy</topic><topic>Carcinoma, Small Cell - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Solitary Pulmonary Nodule - mortality</topic><topic>Solitary Pulmonary Nodule - pathology</topic><topic>Solitary Pulmonary Nodule - radiotherapy</topic><topic>Solitary Pulmonary Nodule - surgery</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quoix, Elisabeth</creatorcontrib><creatorcontrib>Fraser, Richard</creatorcontrib><creatorcontrib>Wolkove, Norman</creatorcontrib><creatorcontrib>Finkelstein, Harriet</creatorcontrib><creatorcontrib>Kreisman, Harvey</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quoix, Elisabeth</au><au>Fraser, Richard</au><au>Wolkove, Norman</au><au>Finkelstein, Harriet</au><au>Kreisman, Harvey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small cell lung cancer presenting as a solitary pulmonary nodule</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1990-08-01</date><risdate>1990</risdate><volume>66</volume><issue>3</issue><spage>577</spage><epage>582</epage><pages>577-582</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Small cell lung cancer (SCLC) rarely presents radiographically as a solitary pulmonary nodule (SPN). Twenty‐five patients with this feature were identified among 408 individuals with SCLC at McGill University (Montreal, Quebec) from 1979 through 1984. Of these, 15 (60%) were confirmed on pathologic review as SCLC (ten intermediate cell, four oat cell, one indeterminate). Pathologic review of a control group comprising 24 other limited‐disease patients who were long‐term survivors (> 20 months) confirmed 20 (84%) as SCLC (eight intermediate cell, 12 oat cell). Ten of the 15 patients with SPN were resected whereas five had chemotherapy and/or radiotherapy as primary treatment. Postoperative chemotherapy was administered to most of the resected patients. The median survival of the 15 patients with SPN was 24 months, a significantly longer survival than the other patients with SCLC. This improved prognosis in patients with SPN may be due to smaller initial tumor burden or to a fundamental biologic difference between SPN and other forms of SCLC.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2163746</pmid><doi>10.1002/1097-0142(19900801)66:3<577::AID-CNCR2820660328>3.0.CO;2-Y</doi><tpages>6</tpages></addata></record> |
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| subjects | Actuarial Analysis Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Small Cell - mortality Carcinoma, Small Cell - pathology Carcinoma, Small Cell - radiotherapy Carcinoma, Small Cell - surgery Female Humans Lung Neoplasms - mortality Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Lung Neoplasms - surgery Male Medical sciences Middle Aged Pneumology Solitary Pulmonary Nodule - mortality Solitary Pulmonary Nodule - pathology Solitary Pulmonary Nodule - radiotherapy Solitary Pulmonary Nodule - surgery Tumors of the respiratory system and mediastinum |
| title | Small cell lung cancer presenting as a solitary pulmonary nodule |
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