effects of thiamin on the tissue distribution of lead
The effects of thiamin on the tissue distribution of lead were evaluated in Sprague–Dawley rats exposed to 1000 ppm lead acetate in drinking water and treated daily with thiamin (25 or 50 mg kg−1 body weight, i.p.), calcium ethylenediamine tetraacetic acid (50 mg kg−1 body weight, i.p.) or their com...
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| Veröffentlicht in: | Journal of applied toxicology 1990-04, Vol.10 (2), p.93-97 |
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| container_end_page | 97 |
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| container_title | Journal of applied toxicology |
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| creator | Kim, J.S Blakley, B.R Rousseaux, C.G |
| description | The effects of thiamin on the tissue distribution of lead were evaluated in Sprague–Dawley rats exposed to 1000 ppm lead acetate in drinking water and treated daily with thiamin (25 or 50 mg kg−1 body weight, i.p.), calcium ethylenediamine tetraacetic acid (50 mg kg−1 body weight, i.p.) or their combination for 8 weeks. The subtoxic dose of lead did not alter weight gains, feed and water consumption during the treatment period. Thiamin decreased the blood (P > 0.0001), liver (P < 0.0001) and kidney (P < 0.0001) concentrations of lead. Thiamin (50 mg kg−1 body weight) reduced the lead concentrations in tissues more effectively than thiamin (25 mg kg−1 body weight). The combined treatment was more effective than the respective individual treatments. |
| doi_str_mv | 10.1002/jat.2550100206 |
| format | Article |
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The subtoxic dose of lead did not alter weight gains, feed and water consumption during the treatment period. Thiamin decreased the blood (P > 0.0001), liver (P < 0.0001) and kidney (P < 0.0001) concentrations of lead. Thiamin (50 mg kg−1 body weight) reduced the lead concentrations in tissues more effectively than thiamin (25 mg kg−1 body weight). The combined treatment was more effective than the respective individual treatments.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.2550100206</identifier><identifier>PMID: 2113935</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; calcium ; Chemical and industrial products toxicology. Toxic occupational diseases ; Drug Therapy, Combination ; Edetic Acid - pharmacology ; EDTA (chelating agent) ; Kidney - metabolism ; lead ; Lead - blood ; Lead - pharmacokinetics ; lead poisoning ; Liver - metabolism ; Male ; Medical sciences ; metabolism ; metal-vitamin interactions ; Metals and various inorganic compounds ; Rats ; Rats, Inbred Strains ; thiamin ; Thiamine - pharmacology ; Tissue Distribution ; Toxicology</subject><ispartof>Journal of applied toxicology, 1990-04, Vol.10 (2), p.93-97</ispartof><rights>Copyright © 1990 John Wiley & Sons, Ltd.</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4936-d8039a914228745fba79699a62bcec53bdbafe0c1f23ebc4cc9a1f2337505b053</citedby><cites>FETCH-LOGICAL-c4936-d8039a914228745fba79699a62bcec53bdbafe0c1f23ebc4cc9a1f2337505b053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjat.2550100206$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjat.2550100206$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6947039$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2113935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, J.S</creatorcontrib><creatorcontrib>Blakley, B.R</creatorcontrib><creatorcontrib>Rousseaux, C.G</creatorcontrib><title>effects of thiamin on the tissue distribution of lead</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>The effects of thiamin on the tissue distribution of lead were evaluated in Sprague–Dawley rats exposed to 1000 ppm lead acetate in drinking water and treated daily with thiamin (25 or 50 mg kg−1 body weight, i.p.), calcium ethylenediamine tetraacetic acid (50 mg kg−1 body weight, i.p.) or their combination for 8 weeks. The subtoxic dose of lead did not alter weight gains, feed and water consumption during the treatment period. Thiamin decreased the blood (P > 0.0001), liver (P < 0.0001) and kidney (P < 0.0001) concentrations of lead. Thiamin (50 mg kg−1 body weight) reduced the lead concentrations in tissues more effectively than thiamin (25 mg kg−1 body weight). The combined treatment was more effective than the respective individual treatments.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>calcium</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Drug Therapy, Combination</subject><subject>Edetic Acid - pharmacology</subject><subject>EDTA (chelating agent)</subject><subject>Kidney - metabolism</subject><subject>lead</subject><subject>Lead - blood</subject><subject>Lead - pharmacokinetics</subject><subject>lead poisoning</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>metabolism</subject><subject>metal-vitamin interactions</subject><subject>Metals and various inorganic compounds</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>thiamin</subject><subject>Thiamine - pharmacology</subject><subject>Tissue Distribution</subject><subject>Toxicology</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9v0zAUgK0JNLqx626IHNBuKc92bMfHqYJtUIEQndjNenFs8EibYSca--_nKlURp5787Pe9H_pMyDmFOQVg7-9xmDMhYHsBeURmFLQuKZP8BZkBk1BWXN29Iicp3QPkHKuPyTGjlGsuZkQ4750dUtH7YvgVcB02Rb_JoSuGkNLoijakIYZmHEJ-z1TnsH1NXnrskjvbnafk9uOH1eK6XH69ullcLktbaS7LtgauUdOKsVpVwjeotNQaJWuss4I3bYPegaWecdfYylqN25grAaIBwU_JxdT3IfZ_RpcGsw7Juq7DjevHZJSuhWKKHwSpEFowVR8GqyxTKp3B-QTa2KcUnTcPMawxPhkKZivbZPPmn_lc8GbXeWzWrt3jO9U5_26Xx2Sx8xE3NqQ9JnWlsq2M6Ql7DJ17OjDUfLpc_bdCOdXmL3N_97UYfxupslTz48uVWbHVAr7Jz2aZ-bcT77E3-DPmdW6_M6AcmAKqqODPzDmyhA</recordid><startdate>199004</startdate><enddate>199004</enddate><creator>Kim, J.S</creator><creator>Blakley, B.R</creator><creator>Rousseaux, C.G</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7TV</scope><scope>7U7</scope><scope>7X8</scope></search><sort><creationdate>199004</creationdate><title>effects of thiamin on the tissue distribution of lead</title><author>Kim, J.S ; Blakley, B.R ; Rousseaux, C.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4936-d8039a914228745fba79699a62bcec53bdbafe0c1f23ebc4cc9a1f2337505b053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>calcium</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Drug Therapy, Combination</topic><topic>Edetic Acid - pharmacology</topic><topic>EDTA (chelating agent)</topic><topic>Kidney - metabolism</topic><topic>lead</topic><topic>Lead - blood</topic><topic>Lead - pharmacokinetics</topic><topic>lead poisoning</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>metabolism</topic><topic>metal-vitamin interactions</topic><topic>Metals and various inorganic compounds</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>thiamin</topic><topic>Thiamine - pharmacology</topic><topic>Tissue Distribution</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, J.S</creatorcontrib><creatorcontrib>Blakley, B.R</creatorcontrib><creatorcontrib>Rousseaux, C.G</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, J.S</au><au>Blakley, B.R</au><au>Rousseaux, C.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>effects of thiamin on the tissue distribution of lead</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>1990-04</date><risdate>1990</risdate><volume>10</volume><issue>2</issue><spage>93</spage><epage>97</epage><pages>93-97</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>The effects of thiamin on the tissue distribution of lead were evaluated in Sprague–Dawley rats exposed to 1000 ppm lead acetate in drinking water and treated daily with thiamin (25 or 50 mg kg−1 body weight, i.p.), calcium ethylenediamine tetraacetic acid (50 mg kg−1 body weight, i.p.) or their combination for 8 weeks. The subtoxic dose of lead did not alter weight gains, feed and water consumption during the treatment period. Thiamin decreased the blood (P > 0.0001), liver (P < 0.0001) and kidney (P < 0.0001) concentrations of lead. Thiamin (50 mg kg−1 body weight) reduced the lead concentrations in tissues more effectively than thiamin (25 mg kg−1 body weight). The combined treatment was more effective than the respective individual treatments.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><pmid>2113935</pmid><doi>10.1002/jat.2550100206</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of applied toxicology, 1990-04, Vol.10 (2), p.93-97 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Biological and medical sciences calcium Chemical and industrial products toxicology. Toxic occupational diseases Drug Therapy, Combination Edetic Acid - pharmacology EDTA (chelating agent) Kidney - metabolism lead Lead - blood Lead - pharmacokinetics lead poisoning Liver - metabolism Male Medical sciences metabolism metal-vitamin interactions Metals and various inorganic compounds Rats Rats, Inbred Strains thiamin Thiamine - pharmacology Tissue Distribution Toxicology |
| title | effects of thiamin on the tissue distribution of lead |
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