Topography of dopamine D-1 and D-2 receptor-mediated rotation after intrastriatal injections of dopamine-related drugs in normosensitive rats
Naive rats were challenged systemically with apomorphine after receiving unilateral dorsal or ventral intracaudate injections of the dopamine D-1 receptor antagonist, SCH23390, or the D-2 receptor antagonist, sulpiride. Sulpiride injections into both the dorsal and ventral striatum induced a robust...
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| Veröffentlicht in: | European journal of pharmacology 1990-04, Vol.179 (1), p.201-205 |
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| creator | Konitsiotis, Spiridon Kafetzopoulos, Evangelos |
| description | Naive rats were challenged systemically with apomorphine after receiving unilateral dorsal or ventral intracaudate injections of the dopamine D-1 receptor antagonist, SCH23390, or the D-2 receptor antagonist, sulpiride. Sulpiride injections into both the dorsal and ventral striatum induced a robust ipsilateral rotation, while SCH23390 elicited a weaker ipsilateral rotation only on injection into the ventral striatum. Both drugs were ineffective in saline-treated rats, although sulpiride injections into the ventral striatum after systemic saline elicited a small ipsilateral preference. The results from this rotational model mediated by normosensitive receptors indicate that only dopamine D-1 receptors in the ventral striatum mediate rotation while D-2 receptors in both striatal regions mediate rotation. A functional dichotomy between these two neostriatal regions is thus proposed. |
| doi_str_mv | 10.1016/0014-2999(90)90419-7 |
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Sulpiride injections into both the dorsal and ventral striatum induced a robust ipsilateral rotation, while SCH23390 elicited a weaker ipsilateral rotation only on injection into the ventral striatum. Both drugs were ineffective in saline-treated rats, although sulpiride injections into the ventral striatum after systemic saline elicited a small ipsilateral preference. The results from this rotational model mediated by normosensitive receptors indicate that only dopamine D-1 receptors in the ventral striatum mediate rotation while D-2 receptors in both striatal regions mediate rotation. A functional dichotomy between these two neostriatal regions is thus proposed.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(90)90419-7</identifier><identifier>PMID: 2142084</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis of Variance ; Animals ; Apomorphine - pharmacology ; Behavior, Animal - drug effects ; Benzazepines - pharmacology ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Corpus striatum ; Corpus Striatum - drug effects ; Dopamine Antagonists ; Dopamine receptors ; Fundamental and applied biological sciences. Psychology ; Injections, Intraperitoneal ; Injections, Intraventricular ; Male ; Motor Activity - drug effects ; Rat ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine - drug effects ; Receptors, Dopamine D1 ; Receptors, Dopamine D2 ; Rotation ; SCH 23390 ; Sulpiride ; Sulpiride - pharmacology ; Vertebrates: nervous system and sense organs</subject><ispartof>European journal of pharmacology, 1990-04, Vol.179 (1), p.201-205</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-4686d90dbe7d989be0a78cc2200cf907c8d2eeae33c751475b5c8de20f0ba7203</citedby><cites>FETCH-LOGICAL-c417t-4686d90dbe7d989be0a78cc2200cf907c8d2eeae33c751475b5c8de20f0ba7203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(90)90419-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6871067$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2142084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Konitsiotis, Spiridon</creatorcontrib><creatorcontrib>Kafetzopoulos, Evangelos</creatorcontrib><title>Topography of dopamine D-1 and D-2 receptor-mediated rotation after intrastriatal injections of dopamine-related drugs in normosensitive rats</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Naive rats were challenged systemically with apomorphine after receiving unilateral dorsal or ventral intracaudate injections of the dopamine D-1 receptor antagonist, SCH23390, or the D-2 receptor antagonist, sulpiride. Sulpiride injections into both the dorsal and ventral striatum induced a robust ipsilateral rotation, while SCH23390 elicited a weaker ipsilateral rotation only on injection into the ventral striatum. Both drugs were ineffective in saline-treated rats, although sulpiride injections into the ventral striatum after systemic saline elicited a small ipsilateral preference. The results from this rotational model mediated by normosensitive receptors indicate that only dopamine D-1 receptors in the ventral striatum mediate rotation while D-2 receptors in both striatal regions mediate rotation. A functional dichotomy between these two neostriatal regions is thus proposed.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Apomorphine - pharmacology</subject><subject>Behavior, Animal - drug effects</subject><subject>Benzazepines - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Corpus striatum</subject><subject>Corpus Striatum - drug effects</subject><subject>Dopamine Antagonists</subject><subject>Dopamine receptors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Dopamine - drug effects</subject><subject>Receptors, Dopamine D1</subject><subject>Receptors, Dopamine D2</subject><subject>Rotation</subject><subject>SCH 23390</subject><subject>Sulpiride</subject><subject>Sulpiride - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1TAUhoMo43X0HyhkIaKL6EmaNs1GkPETBtyM65Amp2OGtqlJ7sD8CP-z6dzLxZWuQvI-5yWch5DnHN5y4N07AC6Z0Fq_1vBGg-SaqQdkx3ulGSguHpLdCXlMnuR8AwCtFu0ZORNcCujljvy-imu8Tnb9eUfjSH1c7RwWpB8Zp3bx9RQ0ocO1xMRm9MEW9DTFYkuIC7VjwUTDUpLNJdXQTvV2g25L89-NLOF0P-vT_jpXiC4xzTHjkkMJt0iTLfkpeTTaKeOz43lOfnz-dHXxlV1-__Lt4sMlc5KrwmTXd16DH1B53esBwareOSEA3KhBud4LRItN41TLpWqHtj6hgBEGqwQ05-TVoXdN8dceczFzyA6nyS4Y99ko3bdSN81_Qd52UnairaA8gC7FnBOOZk1htunOcDCbLrO5MJsLo8Hc6zKqjr049u-Hut3T0NFPzV8ec5udncZkFxfyCet6xaHbat4fMKxLuw2YTHYBF1d9VXnF-Bj-_Y8_ItWzYQ</recordid><startdate>19900410</startdate><enddate>19900410</enddate><creator>Konitsiotis, Spiridon</creator><creator>Kafetzopoulos, Evangelos</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19900410</creationdate><title>Topography of dopamine D-1 and D-2 receptor-mediated rotation after intrastriatal injections of dopamine-related drugs in normosensitive rats</title><author>Konitsiotis, Spiridon ; Kafetzopoulos, Evangelos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-4686d90dbe7d989be0a78cc2200cf907c8d2eeae33c751475b5c8de20f0ba7203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Apomorphine - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>Benzazepines - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Corpus striatum</topic><topic>Corpus Striatum - drug effects</topic><topic>Dopamine Antagonists</topic><topic>Dopamine receptors</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Motor Activity - drug effects</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Dopamine - drug effects</topic><topic>Receptors, Dopamine D1</topic><topic>Receptors, Dopamine D2</topic><topic>Rotation</topic><topic>SCH 23390</topic><topic>Sulpiride</topic><topic>Sulpiride - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Konitsiotis, Spiridon</creatorcontrib><creatorcontrib>Kafetzopoulos, Evangelos</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Konitsiotis, Spiridon</au><au>Kafetzopoulos, Evangelos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topography of dopamine D-1 and D-2 receptor-mediated rotation after intrastriatal injections of dopamine-related drugs in normosensitive rats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1990-04-10</date><risdate>1990</risdate><volume>179</volume><issue>1</issue><spage>201</spage><epage>205</epage><pages>201-205</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Naive rats were challenged systemically with apomorphine after receiving unilateral dorsal or ventral intracaudate injections of the dopamine D-1 receptor antagonist, SCH23390, or the D-2 receptor antagonist, sulpiride. Sulpiride injections into both the dorsal and ventral striatum induced a robust ipsilateral rotation, while SCH23390 elicited a weaker ipsilateral rotation only on injection into the ventral striatum. Both drugs were ineffective in saline-treated rats, although sulpiride injections into the ventral striatum after systemic saline elicited a small ipsilateral preference. The results from this rotational model mediated by normosensitive receptors indicate that only dopamine D-1 receptors in the ventral striatum mediate rotation while D-2 receptors in both striatal regions mediate rotation. A functional dichotomy between these two neostriatal regions is thus proposed.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2142084</pmid><doi>10.1016/0014-2999(90)90419-7</doi><tpages>5</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Apomorphine - pharmacology Behavior, Animal - drug effects Benzazepines - pharmacology Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Corpus striatum Corpus Striatum - drug effects Dopamine Antagonists Dopamine receptors Fundamental and applied biological sciences. Psychology Injections, Intraperitoneal Injections, Intraventricular Male Motor Activity - drug effects Rat Rats Rats, Inbred Strains Receptors, Dopamine - drug effects Receptors, Dopamine D1 Receptors, Dopamine D2 Rotation SCH 23390 Sulpiride Sulpiride - pharmacology Vertebrates: nervous system and sense organs |
| title | Topography of dopamine D-1 and D-2 receptor-mediated rotation after intrastriatal injections of dopamine-related drugs in normosensitive rats |
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