Metal ion co-ordination in the DNA binding domain of the yeast transcriptional activator GAL4
The structure of the DNA binding domain of the yeast transcriptional activator GAL4 was investigated by extended X-ray fine structure (e.x.a.f.s.). Two samples of GAL4 were studied, one containing cadmium as a structural probe (Cd(II)GAL4) and the other containing the ‘native’ zinc (Zn(Il)-GAL4). Th...
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| Veröffentlicht in: | FEBS letters 1990-06, Vol.266 (1), p.142-146 |
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| creator | Povey, Jane F. Diakun, Gregory P. Garner, C.David Wilson, Stephen P. Laue, Ernest D. |
| description | The structure of the DNA binding domain of the yeast transcriptional activator GAL4 was investigated by extended X-ray fine structure (e.x.a.f.s.). Two samples of GAL4 were studied, one containing cadmium as a structural probe (Cd(II)GAL4) and the other containing the ‘native’ zinc (Zn(Il)-GAL4). The results suggest that the structure of the DNA binding domain of GAL4 contains a two metal ion cluster distinguishing it from the ‘zinc finger’ proteins typified by the
Xenopus laevis transcription factor TFIIIA. |
| doi_str_mv | 10.1016/0014-5793(90)81525-S |
| format | Article |
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Xenopus laevis transcription factor TFIIIA.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Binding and carrier proteins</subject><subject>Biological and medical sciences</subject><subject>Cadmium</subject><subject>Cations, Divalent</subject><subject>DNA</subject><subject>DNA binding</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>DNA-Binding Proteins - ultrastructure</subject><subject>Extended X-ray fine structure</subject><subject>Fourier Analysis</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Fungal Proteins - metabolism</topic><topic>Fungal Proteins - ultrastructure</topic><topic>GAL4</topic><topic>GAL4 protein</topic><topic>In Vitro Techniques</topic><topic>Proteins</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae Proteins</topic><topic>Spectrum Analysis</topic><topic>Structure</topic><topic>Sulfur</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription Factors - ultrastructure</topic><topic>X-ray diffraction</topic><topic>X-Rays</topic><topic>Zinc</topic><topic>Zinc finger</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Povey, Jane F.</creatorcontrib><creatorcontrib>Diakun, Gregory P.</creatorcontrib><creatorcontrib>Garner, C.David</creatorcontrib><creatorcontrib>Wilson, Stephen P.</creatorcontrib><creatorcontrib>Laue, Ernest D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Povey, Jane F.</au><au>Diakun, Gregory P.</au><au>Garner, C.David</au><au>Wilson, Stephen P.</au><au>Laue, Ernest D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metal ion co-ordination in the DNA binding domain of the yeast transcriptional activator GAL4</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1990-06-18</date><risdate>1990</risdate><volume>266</volume><issue>1</issue><spage>142</spage><epage>146</epage><pages>142-146</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>The structure of the DNA binding domain of the yeast transcriptional activator GAL4 was investigated by extended X-ray fine structure (e.x.a.f.s.). Two samples of GAL4 were studied, one containing cadmium as a structural probe (Cd(II)GAL4) and the other containing the ‘native’ zinc (Zn(Il)-GAL4). The results suggest that the structure of the DNA binding domain of GAL4 contains a two metal ion cluster distinguishing it from the ‘zinc finger’ proteins typified by the
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Analytical, structural and metabolic biochemistry Binding and carrier proteins Biological and medical sciences Cadmium Cations, Divalent DNA DNA binding DNA-Binding Proteins - metabolism DNA-Binding Proteins - ultrastructure Extended X-ray fine structure Fourier Analysis Fundamental and applied biological sciences. Psychology Fungal Proteins - metabolism Fungal Proteins - ultrastructure GAL4 GAL4 protein In Vitro Techniques Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Spectrum Analysis Structure Sulfur Transcription Factors - metabolism Transcription Factors - ultrastructure X-ray diffraction X-Rays Zinc Zinc finger |
| title | Metal ion co-ordination in the DNA binding domain of the yeast transcriptional activator GAL4 |
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