Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine

Macrophages consume cystine and generate approximately equivalent amounts of acid-soluble thiol. Stimulation of macrophages with bacterial lipopolysaccharide (LPS) or tumor necrosis factor (TNF) strongly augments the amount of thiol released into the culture supernatant. Cysteine constitutes most of...

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Veröffentlicht in:	Cellular immunology 1990-08, Vol.129 (1), p.32-46
Hauptverfasser:	Gmünder, Helmut, Eck, Hans-Peter, Benninghoff, Bernd, Roth, Steffen, Dröge, Wulf
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Cell Communication Clone Cells Cysteine - biosynthesis Cysteine - physiology DNA - biosynthesis Fundamental and applied biological sciences. Psychology Fundamental immunology Glutathione - metabolism Immunobiology Lymphocytes - metabolism Macrophages - metabolism Macrophages - physiology Mice Mice, Inbred C3H Mice, Inbred C57BL Miscellaneous Regulatory factors and their cellular receptors T-Lymphocytes - metabolism T-Lymphocytes, Cytotoxic - metabolism
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