Expression of genes coding for pS2, c-erbB2, estrogen receptor and the H23 breast tumor-associated antigen: A comparative analysis in breast cancer
Expression of the gene coding for a new breast tumor-associated antigen, H23, was compared to expression of genes coding for pS2, c-erbB2 and estrogen receptor (ER). Comparison involved mRNA expression in normal and malignant breast tissues as well as in non-breast tumors. Results obtained by RNA do...
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| Veröffentlicht in: | FEBS letters 1990-06, Vol.265 (1), p.46-50 |
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| creator | Zaretsky, Joseph Z. Weiss, Mordechai Tsarfaty, Ilan Hareuveni, Mara Wreschner, Daniel H. Keydar, Iafa |
| description | Expression of the gene coding for a new breast tumor-associated antigen, H23, was compared to expression of genes coding for pS2, c-erbB2 and estrogen receptor (ER). Comparison involved mRNA expression in normal and malignant breast tissues as well as in non-breast tumors. Results obtained by RNA dot blot and Northern hybridizations showed that expression of the H23 antigen coding gene is a discriminatory marker in human breast cancer. It is expressed in 92% of breast tumors whereas 69%, 62% and 56% of breast tumors demonstrate significant mRNA levels of c-erbB2, ER and pS2, respectively. Non-malignant or normal breast tissue expresses much lower levels of the H23 antigen mRNA. From the comparative analysis presented here it is concluded that the gene coding for H23 antigen furnishes a most useful marker for human breast cancer. |
| doi_str_mv | 10.1016/0014-5793(90)80880-R |
| format | Article |
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Comparison involved mRNA expression in normal and malignant breast tissues as well as in non-breast tumors. Results obtained by RNA dot blot and Northern hybridizations showed that expression of the H23 antigen coding gene is a discriminatory marker in human breast cancer. It is expressed in 92% of breast tumors whereas 69%, 62% and 56% of breast tumors demonstrate significant mRNA levels of c-erbB2, ER and pS2, respectively. Non-malignant or normal breast tissue expresses much lower levels of the H23 antigen mRNA. From the comparative analysis presented here it is concluded that the gene coding for H23 antigen furnishes a most useful marker for human breast cancer.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(90)80880-R</identifier><identifier>PMID: 2194831</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; antigen (tumor-associated) ; Biological and medical sciences ; Blotting, Northern ; Breast - metabolism ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Breast tumor antigen H23 ; Breast tumor antigen pS2 ; ErbB Receptors ; Estrogen receptor ; estrogens ; Estrogens - metabolism ; Female ; Gene Expression ; Host-tumor relations. Immunology. Biological markers ; Humans ; Medical sciences ; Neoplasm Proteins - genetics ; Oncogene erbB2 ; Protein-Tyrosine Kinases - genetics ; Proteins ; Proto-Oncogene Proteins - genetics ; Receptors, Estrogen - genetics ; RNA, Messenger - genetics ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - metabolism ; Trefoil Factor-1 ; Tumor Suppressor Proteins ; Tumors</subject><ispartof>FEBS letters, 1990-06, Vol.265 (1), p.46-50</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c367t-d6ffe8b29d5911dfc989a258a3d2e32d0223ba97ca6364c384a285b5fec0a9553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-5793(90)80880-R$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19766041$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2194831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaretsky, Joseph Z.</creatorcontrib><creatorcontrib>Weiss, Mordechai</creatorcontrib><creatorcontrib>Tsarfaty, Ilan</creatorcontrib><creatorcontrib>Hareuveni, Mara</creatorcontrib><creatorcontrib>Wreschner, Daniel H.</creatorcontrib><creatorcontrib>Keydar, Iafa</creatorcontrib><title>Expression of genes coding for pS2, c-erbB2, estrogen receptor and the H23 breast tumor-associated antigen: A comparative analysis in breast cancer</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Expression of the gene coding for a new breast tumor-associated antigen, H23, was compared to expression of genes coding for pS2, c-erbB2 and estrogen receptor (ER). Comparison involved mRNA expression in normal and malignant breast tissues as well as in non-breast tumors. Results obtained by RNA dot blot and Northern hybridizations showed that expression of the H23 antigen coding gene is a discriminatory marker in human breast cancer. It is expressed in 92% of breast tumors whereas 69%, 62% and 56% of breast tumors demonstrate significant mRNA levels of c-erbB2, ER and pS2, respectively. Non-malignant or normal breast tissue expresses much lower levels of the H23 antigen mRNA. From the comparative analysis presented here it is concluded that the gene coding for H23 antigen furnishes a most useful marker for human breast cancer.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>antigen (tumor-associated)</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Breast - metabolism</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast tumor antigen H23</subject><subject>Breast tumor antigen pS2</subject><subject>ErbB Receptors</subject><subject>Estrogen receptor</subject><subject>estrogens</subject><subject>Estrogens - metabolism</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Host-tumor relations. Immunology. Biological markers</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Neoplasm Proteins - genetics</subject><subject>Oncogene erbB2</subject><subject>Protein-Tyrosine Kinases - genetics</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Receptors, Estrogen - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Trefoil Factor-1</subject><subject>Tumor Suppressor Proteins</subject><subject>Tumors</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd1qFTEUhYMo9bT6Bgq5USo4mp_JTOKFUEu1QkGoeh0yyZ4aOTOZZucU-xy-sDmeY73Tq_zsby2StQh5wtkrznj3mjHeNqo38tiwF5ppzZrLe2TFdS8b2Xb6PlndIQ_JIeJ3Vs-amwNyILhpteQr8vPsx5IBMaaZppFewQxIfQpxvqJjynT5LF5S30Ae3tUNYMmpMjSDh6XUuZsDLd-AngtJhwwOCy2bKeXGISYfXYFQmRKr6A09qc7T4rIr8QbqtVvfYkQa5z9S72YP-RF5MLo1wuP9ekS-vj_7cnreXHz68PH05KLxsutLE7pxBD0IE5ThPIzeaOOE0k4GAVIEJoQcnOm962TXeqlbJ7Qa1AieOaOUPCLPd75LTteb-jc7RfSwXrsZ0gZtb7RqVSv-C3LVM6lMV8F2B_qcEDOMdslxcvnWcma3pdltI3bbiDXM_i7NXlbZ073_Zpgg3In2LdX5s_3coXfrMdeYIv71Nn3XsXbLvd1xUFO7iZAt-gg10hBrYcWGFP_9kF-CWrP8</recordid><startdate>19900604</startdate><enddate>19900604</enddate><creator>Zaretsky, Joseph Z.</creator><creator>Weiss, Mordechai</creator><creator>Tsarfaty, Ilan</creator><creator>Hareuveni, Mara</creator><creator>Wreschner, Daniel H.</creator><creator>Keydar, Iafa</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19900604</creationdate><title>Expression of genes coding for pS2, c-erbB2, estrogen receptor and the H23 breast tumor-associated antigen: A comparative analysis in breast cancer</title><author>Zaretsky, Joseph Z. ; Weiss, Mordechai ; Tsarfaty, Ilan ; Hareuveni, Mara ; Wreschner, Daniel H. ; Keydar, Iafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-d6ffe8b29d5911dfc989a258a3d2e32d0223ba97ca6364c384a285b5fec0a9553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - metabolism</topic><topic>antigen (tumor-associated)</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Breast - metabolism</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast tumor antigen H23</topic><topic>Breast tumor antigen pS2</topic><topic>ErbB Receptors</topic><topic>Estrogen receptor</topic><topic>estrogens</topic><topic>Estrogens - metabolism</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Host-tumor relations. Immunology. Biological markers</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Neoplasm Proteins - genetics</topic><topic>Oncogene erbB2</topic><topic>Protein-Tyrosine Kinases - genetics</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Receptors, Estrogen - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Trefoil Factor-1</topic><topic>Tumor Suppressor Proteins</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zaretsky, Joseph Z.</creatorcontrib><creatorcontrib>Weiss, Mordechai</creatorcontrib><creatorcontrib>Tsarfaty, Ilan</creatorcontrib><creatorcontrib>Hareuveni, Mara</creatorcontrib><creatorcontrib>Wreschner, Daniel H.</creatorcontrib><creatorcontrib>Keydar, Iafa</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zaretsky, Joseph Z.</au><au>Weiss, Mordechai</au><au>Tsarfaty, Ilan</au><au>Hareuveni, Mara</au><au>Wreschner, Daniel H.</au><au>Keydar, Iafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of genes coding for pS2, c-erbB2, estrogen receptor and the H23 breast tumor-associated antigen: A comparative analysis in breast cancer</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1990-06-04</date><risdate>1990</risdate><volume>265</volume><issue>1</issue><spage>46</spage><epage>50</epage><pages>46-50</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>Expression of the gene coding for a new breast tumor-associated antigen, H23, was compared to expression of genes coding for pS2, c-erbB2 and estrogen receptor (ER). Comparison involved mRNA expression in normal and malignant breast tissues as well as in non-breast tumors. Results obtained by RNA dot blot and Northern hybridizations showed that expression of the H23 antigen coding gene is a discriminatory marker in human breast cancer. It is expressed in 92% of breast tumors whereas 69%, 62% and 56% of breast tumors demonstrate significant mRNA levels of c-erbB2, ER and pS2, respectively. Non-malignant or normal breast tissue expresses much lower levels of the H23 antigen mRNA. From the comparative analysis presented here it is concluded that the gene coding for H23 antigen furnishes a most useful marker for human breast cancer.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2194831</pmid><doi>10.1016/0014-5793(90)80880-R</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - genetics Adenocarcinoma - metabolism antigen (tumor-associated) Biological and medical sciences Blotting, Northern Breast - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast tumor antigen H23 Breast tumor antigen pS2 ErbB Receptors Estrogen receptor estrogens Estrogens - metabolism Female Gene Expression Host-tumor relations. Immunology. Biological markers Humans Medical sciences Neoplasm Proteins - genetics Oncogene erbB2 Protein-Tyrosine Kinases - genetics Proteins Proto-Oncogene Proteins - genetics Receptors, Estrogen - genetics RNA, Messenger - genetics Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Trefoil Factor-1 Tumor Suppressor Proteins Tumors |
| title | Expression of genes coding for pS2, c-erbB2, estrogen receptor and the H23 breast tumor-associated antigen: A comparative analysis in breast cancer |
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