More precise localization of the gene for Hunter syndrome
A linkage analysis between the Hunter syndrome locus (IDS) and four polymorphic loci of the Xq27–Xq28 region, DXS105, DXS98, DXS304, and DXS52, was performed in large families. A significant lod score was obtained between DXS304 and the Hunter gene ( Z max = 6.57 at θ max = 0.0). The Hunter gene can...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1990-07, Vol.7 (3), p.358-362 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Le Guern, E. Couillin, P. Oberlé, I. Ravise, N. Boue, J. |
| description | A linkage analysis between the Hunter syndrome locus (IDS) and four polymorphic loci of the Xq27–Xq28 region, DXS105, DXS98, DXS304, and DXS52, was performed in large families. A significant lod score was obtained between DXS304 and the Hunter gene (
Z
max = 6.57 at
θ
max = 0.0). The Hunter gene can be localized within 7 cM of this marker. In addition, the translocation breakpoint of the Hunter female case described by J. Mossman
et al. (1986,
Arch. Dis. Child. 58: 911–915) was localized between DXS98 and DXS304 using somatic cell hybrids. These two results are in agreement and give the following order: DXS105-DXS98-IDS-DXS304-DXS52. Probes for these marker loci can thus be used for carrier detection. |
| doi_str_mv | 10.1016/0888-7543(90)90169-U |
| format | Article |
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Z
max = 6.57 at
θ
max = 0.0). The Hunter gene can be localized within 7 cM of this marker. In addition, the translocation breakpoint of the Hunter female case described by J. Mossman
et al. (1986,
Arch. Dis. Child. 58: 911–915) was localized between DXS98 and DXS304 using somatic cell hybrids. These two results are in agreement and give the following order: DXS105-DXS98-IDS-DXS304-DXS52. Probes for these marker loci can thus be used for carrier detection.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1016/0888-7543(90)90169-U</identifier><identifier>PMID: 2114352</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Chromosome Mapping ; Cricetinae ; Female ; Genes ; Genetic Linkage ; Genetic Markers ; Humans ; Hybrid Cells ; Lod Score ; Male ; Mice ; Mucopolysaccharidosis II - genetics ; Pedigree ; X Chromosome</subject><ispartof>Genomics (San Diego, Calif.), 1990-07, Vol.7 (3), p.358-362</ispartof><rights>1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-d400e48f7c9a6840560baaa71adc67320058a1a19aa8c88f8a6c61b92c128e053</citedby><cites>FETCH-LOGICAL-c357t-d400e48f7c9a6840560baaa71adc67320058a1a19aa8c88f8a6c61b92c128e053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/088875439090169U$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2114352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Le Guern, E.</creatorcontrib><creatorcontrib>Couillin, P.</creatorcontrib><creatorcontrib>Oberlé, I.</creatorcontrib><creatorcontrib>Ravise, N.</creatorcontrib><creatorcontrib>Boue, J.</creatorcontrib><title>More precise localization of the gene for Hunter syndrome</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>A linkage analysis between the Hunter syndrome locus (IDS) and four polymorphic loci of the Xq27–Xq28 region, DXS105, DXS98, DXS304, and DXS52, was performed in large families. A significant lod score was obtained between DXS304 and the Hunter gene (
Z
max = 6.57 at
θ
max = 0.0). The Hunter gene can be localized within 7 cM of this marker. In addition, the translocation breakpoint of the Hunter female case described by J. Mossman
et al. (1986,
Arch. Dis. Child. 58: 911–915) was localized between DXS98 and DXS304 using somatic cell hybrids. These two results are in agreement and give the following order: DXS105-DXS98-IDS-DXS304-DXS52. Probes for these marker loci can thus be used for carrier detection.</description><subject>Animals</subject><subject>Chromosome Mapping</subject><subject>Cricetinae</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic Linkage</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>Hybrid Cells</subject><subject>Lod Score</subject><subject>Male</subject><subject>Mice</subject><subject>Mucopolysaccharidosis II - genetics</subject><subject>Pedigree</subject><subject>X Chromosome</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9LwzAUx4Moc07_A4WeRA_VlzZJk4sgQ50w8eLOIUtfNdI2M2mF-dfbubGjpwfv--PxPoScU7ihQMUtSCnTgrP8SsG1GjYqXRyQMQWpUimYOCTjveWYnMT4CQAql9mIjDJKWc6zMVEvPmCyCmhdxKT21tTux3TOt4mvku4Dk3dsMal8SGZ922FI4rotg2_wlBxVpo54tpsTsnh8eJvO0vnr0_P0fp7anBddWjIAZLIqrDJCMuAClsaYgprSiiLPALg01FBljLRSVtIIK-hSZZZmEoHnE3K57V0F_9Vj7HTjosW6Ni36PupCSc4YV4ORbY02-BgDVnoVXGPCWlPQG2J6g0NvcGgF-o-YXgyxi11_v2yw3Id2iAb9bqvj8OS3w6CjddhaLN1ArdOld_8f-AXNqXnN</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Le Guern, E.</creator><creator>Couillin, P.</creator><creator>Oberlé, I.</creator><creator>Ravise, N.</creator><creator>Boue, J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900701</creationdate><title>More precise localization of the gene for Hunter syndrome</title><author>Le Guern, E. ; Couillin, P. ; Oberlé, I. ; Ravise, N. ; Boue, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-d400e48f7c9a6840560baaa71adc67320058a1a19aa8c88f8a6c61b92c128e053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Chromosome Mapping</topic><topic>Cricetinae</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic Linkage</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>Hybrid Cells</topic><topic>Lod Score</topic><topic>Male</topic><topic>Mice</topic><topic>Mucopolysaccharidosis II - genetics</topic><topic>Pedigree</topic><topic>X Chromosome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le Guern, E.</creatorcontrib><creatorcontrib>Couillin, P.</creatorcontrib><creatorcontrib>Oberlé, I.</creatorcontrib><creatorcontrib>Ravise, N.</creatorcontrib><creatorcontrib>Boue, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Guern, E.</au><au>Couillin, P.</au><au>Oberlé, I.</au><au>Ravise, N.</au><au>Boue, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>More precise localization of the gene for Hunter syndrome</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>7</volume><issue>3</issue><spage>358</spage><epage>362</epage><pages>358-362</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>A linkage analysis between the Hunter syndrome locus (IDS) and four polymorphic loci of the Xq27–Xq28 region, DXS105, DXS98, DXS304, and DXS52, was performed in large families. A significant lod score was obtained between DXS304 and the Hunter gene (
Z
max = 6.57 at
θ
max = 0.0). The Hunter gene can be localized within 7 cM of this marker. In addition, the translocation breakpoint of the Hunter female case described by J. Mossman
et al. (1986,
Arch. Dis. Child. 58: 911–915) was localized between DXS98 and DXS304 using somatic cell hybrids. These two results are in agreement and give the following order: DXS105-DXS98-IDS-DXS304-DXS52. Probes for these marker loci can thus be used for carrier detection.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2114352</pmid><doi>10.1016/0888-7543(90)90169-U</doi><tpages>5</tpages></addata></record> |
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| ispartof | Genomics (San Diego, Calif.), 1990-07, Vol.7 (3), p.358-362 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Chromosome Mapping Cricetinae Female Genes Genetic Linkage Genetic Markers Humans Hybrid Cells Lod Score Male Mice Mucopolysaccharidosis II - genetics Pedigree X Chromosome |
| title | More precise localization of the gene for Hunter syndrome |
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