N-methyl-D-aspartate-induced neuronal activation is selectively modulated by σ receptors

The effects of two high-affinity σ ligands, DTG (1,3-di(2-tolyl)guanidine) and haloperidol, on the activation of dorsal hippocampus pyramidal neurons induced by microiontopheretic application of N-methyl-D-aspartate (NMDA) were assessed electrophysiologically. Low doses of DTG (0.5–3 μg/kg i.v.) pot...

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Veröffentlicht in:	European journal of pharmacology 1990-04, Vol.179 (3), p.441-445
Hauptverfasser:	Monnet, François P., Debonnel, Guy, Junien, Jean-Louis, De Montigny, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid - analogs & derivatives Aspartic Acid - pharmacology Guanidines - pharmacology Haloperidol - pharmacology Hippocampus (dorsal) In Vitro Techniques Iontophoresis Kainate Kainic Acid - pharmacology Male N-Methylaspartate Neurons - drug effects NMDA (N-methyl-D-aspartate) Oxadiazoles - pharmacology Quisqualate Quisqualic Acid Rats Rats, Inbred Strains Receptors, Opioid - physiology Receptors, sigma Spiperone - pharmacology σReceptors
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