Molecular Localization of the Transforming and Secretory Properties of PDGF A and PDGF B
Human platelet-derived growth factor (PDGF) is a connective tissue cell mitogen comprised of two related chains encoded by distinct genes. The B chain is the homolog of the v-sis oncogene product. Properties that distinguish these ligands include greater transforming potency of the B chain and more...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1990-06, Vol.248 (4962), p.1541-1544 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1544 |
|---|---|
| container_issue | 4962 |
| container_start_page | 1541 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 248 |
| creator | LaRochelle, William J. Giese, Neill May-Siroff, Mary Robbins, Keith C. Aaronson, Stuart A. |
| description | Human platelet-derived growth factor (PDGF) is a connective tissue cell mitogen comprised of two related chains encoded by distinct genes. The B chain is the homolog of the v-sis oncogene product. Properties that distinguish these ligands include greater transforming potency of the B chain and more efficient secretion of the A chain. By a strategy involving the generation of PDGF A and B chimeras, these properties were mapped to distinct domains of the respective molecules. Increased transforming efficiency segregated with the ability to activate both α and β PDGF receptors. These findings genetically map PDGF B residues 105 to 144 as responsible for conformational alterations critical to β PDGF receptor interaction and provide a mechanistic basis for the greater transforming potency of the PDGF B chain. |
| doi_str_mv | 10.1126/science.2163109 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_79852790</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A9190755</galeid><jstor_id>2874764</jstor_id><sourcerecordid>A9190755</sourcerecordid><originalsourceid>FETCH-LOGICAL-c671t-b08235155eeb5ba3bd8a5892b7bff97aab1a9d07e98a16bae5550da08568c8ae3</originalsourceid><addsrcrecordid>eNqN0kFv0zAUB_AIgUYZnLmAFO3ADiObncSJfewKK5MKnbSBuFkvzktI5cTFTiTGp8ddIzZQBVUkx_L7-SnR-wfBS0pOKY2zM6ca7BSexjRLKBGPgolfWSRikjwOJoQkWcRJzp4Gz5xbEeJrIjkIDkY-Cb5-NBrVoMGGC6NANz-hb0wXmirsv2F4Y6FzlbFt09UhdGV4jcpib-xteGXNGm3foNvgq3fzi3B6R-6258-DJxVohy_G92Hw-eL9zexDtFjOL2fTRaSynPZRQXicMMoYYsEKSIqSA-MiLvKiqkQOUFAQJclRcKBZAcgYIyUQzjKuOGByGLzZ9l1b831A18u2cQq1hg7N4GQuOItzQTw8_jdMk5gL_y3_bUkznmZpsml59BdcmcF2_ndlTBOWpiTfoJMtqkGjbLrK9BZUjR1a0KbDqvHHU0GFHxPz-u0O7Z8S20bt4Md_cC96_NHXMDgnL68_7SuXX_aV5_M9JZ8vHsqTXVIZrbFG6RMxWz7UZ1utrHHOYiXXtmnB3kpK5Cb2coy9HHPsb7weJzEULZa__X391ba-cj6892Wep7kf5S_o-AJ4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213544070</pqid></control><display><type>article</type><title>Molecular Localization of the Transforming and Secretory Properties of PDGF A and PDGF B</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>American Association for the Advancement of Science</source><creator>LaRochelle, William J. ; Giese, Neill ; May-Siroff, Mary ; Robbins, Keith C. ; Aaronson, Stuart A.</creator><creatorcontrib>LaRochelle, William J. ; Giese, Neill ; May-Siroff, Mary ; Robbins, Keith C. ; Aaronson, Stuart A.</creatorcontrib><description>Human platelet-derived growth factor (PDGF) is a connective tissue cell mitogen comprised of two related chains encoded by distinct genes. The B chain is the homolog of the v-sis oncogene product. Properties that distinguish these ligands include greater transforming potency of the B chain and more efficient secretion of the A chain. By a strategy involving the generation of PDGF A and B chimeras, these properties were mapped to distinct domains of the respective molecules. Increased transforming efficiency segregated with the ability to activate both α and β PDGF receptors. These findings genetically map PDGF B residues 105 to 144 as responsible for conformational alterations critical to β PDGF receptor interaction and provide a mechanistic basis for the greater transforming potency of the PDGF B chain.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.2163109</identifier><identifier>PMID: 2163109</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Society for the Advancement of Science</publisher><subject>3T3 cells ; Amino acids ; Antibodies ; Cell Line, Transformed ; Cell membranes ; Cell Transformation, Neoplastic ; Cellular biology ; Chimera ; Chimeras ; Genetic aspects ; Genetic Vectors ; Genetics ; Humans ; Ligands ; Mitogens ; Molecules ; NIH 3T3 cells ; Phosphorylation ; Physical growth ; Platelet-derived growth factor ; Platelet-Derived Growth Factor - genetics ; Platelet-Derived Growth Factor - metabolism ; Platelet-Derived Growth Factor - physiology ; Precipitin Tests ; Proteins ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins - physiology ; Proto-Oncogene Proteins c-sis ; Receptors ; Receptors, Cell Surface - genetics ; Receptors, Platelet-Derived Growth Factor ; Transfection</subject><ispartof>Science (American Association for the Advancement of Science), 1990-06, Vol.248 (4962), p.1541-1544</ispartof><rights>Copyright 1990 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1990 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1990 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jun 22, 1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c671t-b08235155eeb5ba3bd8a5892b7bff97aab1a9d07e98a16bae5550da08568c8ae3</citedby><cites>FETCH-LOGICAL-c671t-b08235155eeb5ba3bd8a5892b7bff97aab1a9d07e98a16bae5550da08568c8ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2874764$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2874764$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2163109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LaRochelle, William J.</creatorcontrib><creatorcontrib>Giese, Neill</creatorcontrib><creatorcontrib>May-Siroff, Mary</creatorcontrib><creatorcontrib>Robbins, Keith C.</creatorcontrib><creatorcontrib>Aaronson, Stuart A.</creatorcontrib><title>Molecular Localization of the Transforming and Secretory Properties of PDGF A and PDGF B</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Human platelet-derived growth factor (PDGF) is a connective tissue cell mitogen comprised of two related chains encoded by distinct genes. The B chain is the homolog of the v-sis oncogene product. Properties that distinguish these ligands include greater transforming potency of the B chain and more efficient secretion of the A chain. By a strategy involving the generation of PDGF A and B chimeras, these properties were mapped to distinct domains of the respective molecules. Increased transforming efficiency segregated with the ability to activate both α and β PDGF receptors. These findings genetically map PDGF B residues 105 to 144 as responsible for conformational alterations critical to β PDGF receptor interaction and provide a mechanistic basis for the greater transforming potency of the PDGF B chain.</description><subject>3T3 cells</subject><subject>Amino acids</subject><subject>Antibodies</subject><subject>Cell Line, Transformed</subject><subject>Cell membranes</subject><subject>Cell Transformation, Neoplastic</subject><subject>Cellular biology</subject><subject>Chimera</subject><subject>Chimeras</subject><subject>Genetic aspects</subject><subject>Genetic Vectors</subject><subject>Genetics</subject><subject>Humans</subject><subject>Ligands</subject><subject>Mitogens</subject><subject>Molecules</subject><subject>NIH 3T3 cells</subject><subject>Phosphorylation</subject><subject>Physical growth</subject><subject>Platelet-derived growth factor</subject><subject>Platelet-Derived Growth Factor - genetics</subject><subject>Platelet-Derived Growth Factor - metabolism</subject><subject>Platelet-Derived Growth Factor - physiology</subject><subject>Precipitin Tests</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins - physiology</subject><subject>Proto-Oncogene Proteins c-sis</subject><subject>Receptors</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Platelet-Derived Growth Factor</subject><subject>Transfection</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0kFv0zAUB_AIgUYZnLmAFO3ADiObncSJfewKK5MKnbSBuFkvzktI5cTFTiTGp8ddIzZQBVUkx_L7-SnR-wfBS0pOKY2zM6ca7BSexjRLKBGPgolfWSRikjwOJoQkWcRJzp4Gz5xbEeJrIjkIDkY-Cb5-NBrVoMGGC6NANz-hb0wXmirsv2F4Y6FzlbFt09UhdGV4jcpib-xteGXNGm3foNvgq3fzi3B6R-6258-DJxVohy_G92Hw-eL9zexDtFjOL2fTRaSynPZRQXicMMoYYsEKSIqSA-MiLvKiqkQOUFAQJclRcKBZAcgYIyUQzjKuOGByGLzZ9l1b831A18u2cQq1hg7N4GQuOItzQTw8_jdMk5gL_y3_bUkznmZpsml59BdcmcF2_ndlTBOWpiTfoJMtqkGjbLrK9BZUjR1a0KbDqvHHU0GFHxPz-u0O7Z8S20bt4Md_cC96_NHXMDgnL68_7SuXX_aV5_M9JZ8vHsqTXVIZrbFG6RMxWz7UZ1utrHHOYiXXtmnB3kpK5Cb2coy9HHPsb7weJzEULZa__X391ba-cj6892Wep7kf5S_o-AJ4</recordid><startdate>19900622</startdate><enddate>19900622</enddate><creator>LaRochelle, William J.</creator><creator>Giese, Neill</creator><creator>May-Siroff, Mary</creator><creator>Robbins, Keith C.</creator><creator>Aaronson, Stuart A.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7TO</scope><scope>7X8</scope></search><sort><creationdate>19900622</creationdate><title>Molecular Localization of the Transforming and Secretory Properties of PDGF A and PDGF B</title><author>LaRochelle, William J. ; Giese, Neill ; May-Siroff, Mary ; Robbins, Keith C. ; Aaronson, Stuart A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c671t-b08235155eeb5ba3bd8a5892b7bff97aab1a9d07e98a16bae5550da08568c8ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>3T3 cells</topic><topic>Amino acids</topic><topic>Antibodies</topic><topic>Cell Line, Transformed</topic><topic>Cell membranes</topic><topic>Cell Transformation, Neoplastic</topic><topic>Cellular biology</topic><topic>Chimera</topic><topic>Chimeras</topic><topic>Genetic aspects</topic><topic>Genetic Vectors</topic><topic>Genetics</topic><topic>Humans</topic><topic>Ligands</topic><topic>Mitogens</topic><topic>Molecules</topic><topic>NIH 3T3 cells</topic><topic>Phosphorylation</topic><topic>Physical growth</topic><topic>Platelet-derived growth factor</topic><topic>Platelet-Derived Growth Factor - genetics</topic><topic>Platelet-Derived Growth Factor - metabolism</topic><topic>Platelet-Derived Growth Factor - physiology</topic><topic>Precipitin Tests</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins - physiology</topic><topic>Proto-Oncogene Proteins c-sis</topic><topic>Receptors</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Platelet-Derived Growth Factor</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LaRochelle, William J.</creatorcontrib><creatorcontrib>Giese, Neill</creatorcontrib><creatorcontrib>May-Siroff, Mary</creatorcontrib><creatorcontrib>Robbins, Keith C.</creatorcontrib><creatorcontrib>Aaronson, Stuart A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Agricultural Science Database</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LaRochelle, William J.</au><au>Giese, Neill</au><au>May-Siroff, Mary</au><au>Robbins, Keith C.</au><au>Aaronson, Stuart A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Localization of the Transforming and Secretory Properties of PDGF A and PDGF B</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1990-06-22</date><risdate>1990</risdate><volume>248</volume><issue>4962</issue><spage>1541</spage><epage>1544</epage><pages>1541-1544</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Human platelet-derived growth factor (PDGF) is a connective tissue cell mitogen comprised of two related chains encoded by distinct genes. The B chain is the homolog of the v-sis oncogene product. Properties that distinguish these ligands include greater transforming potency of the B chain and more efficient secretion of the A chain. By a strategy involving the generation of PDGF A and B chimeras, these properties were mapped to distinct domains of the respective molecules. Increased transforming efficiency segregated with the ability to activate both α and β PDGF receptors. These findings genetically map PDGF B residues 105 to 144 as responsible for conformational alterations critical to β PDGF receptor interaction and provide a mechanistic basis for the greater transforming potency of the PDGF B chain.</abstract><cop>United States</cop><pub>American Society for the Advancement of Science</pub><pmid>2163109</pmid><doi>10.1126/science.2163109</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1990-06, Vol.248 (4962), p.1541-1544 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79852790 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | 3T3 cells Amino acids Antibodies Cell Line, Transformed Cell membranes Cell Transformation, Neoplastic Cellular biology Chimera Chimeras Genetic aspects Genetic Vectors Genetics Humans Ligands Mitogens Molecules NIH 3T3 cells Phosphorylation Physical growth Platelet-derived growth factor Platelet-Derived Growth Factor - genetics Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - physiology Precipitin Tests Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-sis Receptors Receptors, Cell Surface - genetics Receptors, Platelet-Derived Growth Factor Transfection |
| title | Molecular Localization of the Transforming and Secretory Properties of PDGF A and PDGF B |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T08%3A23%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20Localization%20of%20the%20Transforming%20and%20Secretory%20Properties%20of%20PDGF%20A%20and%20PDGF%20B&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=LaRochelle,%20William%20J.&rft.date=1990-06-22&rft.volume=248&rft.issue=4962&rft.spage=1541&rft.epage=1544&rft.pages=1541-1544&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.2163109&rft_dat=%3Cgale_proqu%3EA9190755%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213544070&rft_id=info:pmid/2163109&rft_galeid=A9190755&rft_jstor_id=2874764&rfr_iscdi=true |