Mediodorsal thalamic lesions impair “Reference” and “working” memory in rats
The present experiment evaluated the ability of rats with lesions in the thalamic mediodorsal nucleus (MD) to perform a task which differentiates between “reference” and “working” memory. In this task, only four of the arms of an 8-arm radial maze were baited, and animals were to restrict their entr...
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| Veröffentlicht in: | Physiology & behavior 1990-03, Vol.47 (3), p.471-476 |
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| container_title | Physiology & behavior |
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| creator | Stokes, Kathryn A Best, Phillip J |
| description | The present experiment evaluated the ability of rats with lesions in the thalamic mediodorsal nucleus (MD) to perform a task which differentiates between “reference” and “working” memory. In this task, only four of the arms of an 8-arm radial maze were baited, and animals were to restrict their entries to arms which were baited and to avoid never-baited arms. Despite several postoperative acquisition trials, rats with MD lesions did not acquire the task to a degree comparable to control subjects. Subjects with lesions continued to enter never-baited arms (reference memory errors) and to reenter baited arms (working memory errors). Given the lack of specificity in the behavioural impairment, the reference-working memory distinction seems to be an inappropriate one for characterizing the MD lesion deficit in rats. This deficit may involve an inability to use environmental stimuli to distinguish among arms of the maze, or an alteration in motor mechanisms. |
| doi_str_mv | 10.1016/0031-9384(90)90111-G |
| format | Article |
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In this task, only four of the arms of an 8-arm radial maze were baited, and animals were to restrict their entries to arms which were baited and to avoid never-baited arms. Despite several postoperative acquisition trials, rats with MD lesions did not acquire the task to a degree comparable to control subjects. Subjects with lesions continued to enter never-baited arms (reference memory errors) and to reenter baited arms (working memory errors). Given the lack of specificity in the behavioural impairment, the reference-working memory distinction seems to be an inappropriate one for characterizing the MD lesion deficit in rats. This deficit may involve an inability to use environmental stimuli to distinguish among arms of the maze, or an alteration in motor mechanisms.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(90)90111-G</identifier><identifier>PMID: 2359755</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>Animals ; Behavior, Animal - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Lesion study ; Male ; Mediodorsal thalamus ; Memory - physiology ; Memory Disorders - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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In this task, only four of the arms of an 8-arm radial maze were baited, and animals were to restrict their entries to arms which were baited and to avoid never-baited arms. Despite several postoperative acquisition trials, rats with MD lesions did not acquire the task to a degree comparable to control subjects. Subjects with lesions continued to enter never-baited arms (reference memory errors) and to reenter baited arms (working memory errors). Given the lack of specificity in the behavioural impairment, the reference-working memory distinction seems to be an inappropriate one for characterizing the MD lesion deficit in rats. This deficit may involve an inability to use environmental stimuli to distinguish among arms of the maze, or an alteration in motor mechanisms.</description><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lesion study</subject><subject>Male</subject><subject>Mediodorsal thalamus</subject><subject>Memory - physiology</subject><subject>Memory Disorders - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Radial maze</subject><subject>Rats</subject><subject>Reference memory</subject><subject>Thalamus - physiology</subject><subject>Working memory</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFqGzEQhkVocdwkb9DCHkpoDtuMVqvV6lIooXEKLoXgQ25Clkatkt2VI61TfMuDtC_nJ8lubXxs5zIw_zfD8BHylsJHCrS6BGA0l6wuP0i4kEApzWdHZEprwXIO4u4VmR6QY_ImpXsYipVsQiYF41JwPiWLb2h9sCEm3WT9T93o1pusweRDlzLfrrSP2fb59y06jNgZ3D7_yXRnx9mvEB9892OctNiGuMl8l0Xdp1Py2ukm4dm-n5DF9ZfF1U0-_z77evV5npuyqvtcc14wKmy1BFmAM7hEMKYyVmIpLAPmBC-dNgXHAjSnjkFNwWgADoxZdkLOd2dXMTyuMfWq9clg0-gOwzopIWte8Ar-C1LOK0brESx3oIkhpYhOraJvddwoCmqUrkajajSqJKi_0tVsWHu3v79etmgPS3vLQ_5-n-tkdOOi7oxPB6yqRSkLMWCfdhgOzp48RpWMH51bH9H0ygb_7z9eAGY8oRo</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>Stokes, Kathryn A</creator><creator>Best, Phillip J</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19900301</creationdate><title>Mediodorsal thalamic lesions impair “Reference” and “working” memory in rats</title><author>Stokes, Kathryn A ; Best, Phillip J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-a552317d6b0920fcebe0cc6cd9e47d303f754fac25e20a51f30810ca005033d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lesion study</topic><topic>Male</topic><topic>Mediodorsal thalamus</topic><topic>Memory - physiology</topic><topic>Memory Disorders - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Radial maze</topic><topic>Rats</topic><topic>Reference memory</topic><topic>Thalamus - physiology</topic><topic>Working memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stokes, Kathryn A</creatorcontrib><creatorcontrib>Best, Phillip J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stokes, Kathryn A</au><au>Best, Phillip J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mediodorsal thalamic lesions impair “Reference” and “working” memory in rats</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1990-03-01</date><risdate>1990</risdate><volume>47</volume><issue>3</issue><spage>471</spage><epage>476</epage><pages>471-476</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>The present experiment evaluated the ability of rats with lesions in the thalamic mediodorsal nucleus (MD) to perform a task which differentiates between “reference” and “working” memory. 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| ispartof | Physiology & behavior, 1990-03, Vol.47 (3), p.471-476 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences Fundamental and applied biological sciences. Psychology Lesion study Male Mediodorsal thalamus Memory - physiology Memory Disorders - physiopathology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Radial maze Rats Reference memory Thalamus - physiology Working memory |
| title | Mediodorsal thalamic lesions impair “Reference” and “working” memory in rats |
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