Specific immune response in humans following rectal delivery of live typhoid vaccine
The specific immune responses to the live vaccine Salmonella typhi Ty21a following rectal administration were determined in serum, peripheral blood lymphocytes, saliva and in jejunal fluid of adult human subjects. Following vaccination, all seven subjects had a detectable anti-typhoid IgA antibody r...
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| Veröffentlicht in: | Vaccine 1990-06, Vol.8 (3), p.209-212 |
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| container_title | Vaccine |
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| creator | Forrest, Bruce D. Shearman, David J.C. LaBrooy, Justin T. |
| description | The specific immune responses to the live vaccine
Salmonella typhi Ty21a following rectal administration were determined in serum, peripheral blood lymphocytes, saliva and in jejunal fluid of adult human subjects. Following vaccination, all seven subjects had a detectable anti-typhoid IgA antibody response using their peripheral blood lymphocytes (
p = 0.009). Significant rises in postvaccination anti-typhoid IgA antibody were observed in the jejunal fluid (
p = 0.033), serum (
p = 0.010) and saliva (
p = 0.050) of these subjects. This study confirms that the normal rectal mucosa is an efficient route of entry to the systemic immune system for microbial agents, and therefore may provide a further possible route of immunization with attenuated bacterial vaccines. |
| doi_str_mv | 10.1016/0264-410X(90)90047-P |
| format | Article |
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Salmonella typhi Ty21a following rectal administration were determined in serum, peripheral blood lymphocytes, saliva and in jejunal fluid of adult human subjects. Following vaccination, all seven subjects had a detectable anti-typhoid IgA antibody response using their peripheral blood lymphocytes (
p = 0.009). Significant rises in postvaccination anti-typhoid IgA antibody were observed in the jejunal fluid (
p = 0.033), serum (
p = 0.010) and saliva (
p = 0.050) of these subjects. This study confirms that the normal rectal mucosa is an efficient route of entry to the systemic immune system for microbial agents, and therefore may provide a further possible route of immunization with attenuated bacterial vaccines.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/0264-410X(90)90047-P</identifier><identifier>PMID: 2363299</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Administration, Rectal ; Adult ; Antibodies, Bacterial - biosynthesis ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Female ; Human bacterial diseases ; Humans ; IgA ; IgG ; IgM ; Immunoglobulin A - biosynthesis ; Infectious diseases ; intestinal immunity ; Intestinal Mucosa - immunology ; Male ; Medical sciences ; Rectal administration ; Salmonella typhi - immunology ; typhoid vaccine ; Typhoid-Paratyphoid Vaccines - administration & dosage ; Typhoid-Paratyphoid Vaccines - immunology ; Vaccines, Attenuated - administration & dosage ; Vaccines, Attenuated - immunology</subject><ispartof>Vaccine, 1990-06, Vol.8 (3), p.209-212</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-7e1657184ca010dc10bf1693357fa3b063287162592d6585224ba26478af788a3</citedby><cites>FETCH-LOGICAL-c417t-7e1657184ca010dc10bf1693357fa3b063287162592d6585224ba26478af788a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0264-410X(90)90047-P$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6885784$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2363299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Forrest, Bruce D.</creatorcontrib><creatorcontrib>Shearman, David J.C.</creatorcontrib><creatorcontrib>LaBrooy, Justin T.</creatorcontrib><title>Specific immune response in humans following rectal delivery of live typhoid vaccine</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>The specific immune responses to the live vaccine
Salmonella typhi Ty21a following rectal administration were determined in serum, peripheral blood lymphocytes, saliva and in jejunal fluid of adult human subjects. Following vaccination, all seven subjects had a detectable anti-typhoid IgA antibody response using their peripheral blood lymphocytes (
p = 0.009). Significant rises in postvaccination anti-typhoid IgA antibody were observed in the jejunal fluid (
p = 0.033), serum (
p = 0.010) and saliva (
p = 0.050) of these subjects. This study confirms that the normal rectal mucosa is an efficient route of entry to the systemic immune system for microbial agents, and therefore may provide a further possible route of immunization with attenuated bacterial vaccines.</description><subject>Administration, Rectal</subject><subject>Adult</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>IgA</subject><subject>IgG</subject><subject>IgM</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Infectious diseases</subject><subject>intestinal immunity</subject><subject>Intestinal Mucosa - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rectal administration</subject><subject>Salmonella typhi - immunology</subject><subject>typhoid vaccine</subject><subject>Typhoid-Paratyphoid Vaccines - administration & dosage</subject><subject>Typhoid-Paratyphoid Vaccines - immunology</subject><subject>Vaccines, Attenuated - administration & dosage</subject><subject>Vaccines, Attenuated - immunology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1rFDEUhoNY6lr9Bwq5kGIvRpPM5OtGkKK1UGjBCt6FbObERmaSMdnZsv_ejLvspb1K4H3ewzkPQm8o-UAJFR8JE13TUfLzvSYXmpBONnfP0Ioq2TaMU_UcrY7IC_SylN-EEN5SfYpOWStapvUK3X-fwAUfHA7jOEfAGcqUYgEcIn6YRxsL9mkY0mOIv2roNnbAPQxhC3mHk8fLD29200MKPd5a50KEV-jE26HA68N7hn58_XJ_-a25ub26vvx807iOyk0jgQouqeqcJZT0jpK1p0K3LZfetmtSV1SSCsY16wVXnLFubetFUlkvlbLtGTrfz51y-jND2ZgxFAfDYCOkuRipFSe1-SRIuaBKM17Bbg-6nErJ4M2Uw2jzzlBiFutmUWoWpUYT88-6uau1t4f583qE_lg6aK75u0Nui7ODzza6UI6YUIpL1VXs0x6DKm0bIJviAkQHfVjMmz6F_-_xF3fXnUI</recordid><startdate>19900601</startdate><enddate>19900601</enddate><creator>Forrest, Bruce D.</creator><creator>Shearman, David J.C.</creator><creator>LaBrooy, Justin T.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19900601</creationdate><title>Specific immune response in humans following rectal delivery of live typhoid vaccine</title><author>Forrest, Bruce D. ; Shearman, David J.C. ; LaBrooy, Justin T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7e1657184ca010dc10bf1693357fa3b063287162592d6585224ba26478af788a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Administration, Rectal</topic><topic>Adult</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>IgA</topic><topic>IgG</topic><topic>IgM</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Infectious diseases</topic><topic>intestinal immunity</topic><topic>Intestinal Mucosa - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rectal administration</topic><topic>Salmonella typhi - immunology</topic><topic>typhoid vaccine</topic><topic>Typhoid-Paratyphoid Vaccines - administration & dosage</topic><topic>Typhoid-Paratyphoid Vaccines - immunology</topic><topic>Vaccines, Attenuated - administration & dosage</topic><topic>Vaccines, Attenuated - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forrest, Bruce D.</creatorcontrib><creatorcontrib>Shearman, David J.C.</creatorcontrib><creatorcontrib>LaBrooy, Justin T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forrest, Bruce D.</au><au>Shearman, David J.C.</au><au>LaBrooy, Justin T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific immune response in humans following rectal delivery of live typhoid vaccine</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>1990-06-01</date><risdate>1990</risdate><volume>8</volume><issue>3</issue><spage>209</spage><epage>212</epage><pages>209-212</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>The specific immune responses to the live vaccine
Salmonella typhi Ty21a following rectal administration were determined in serum, peripheral blood lymphocytes, saliva and in jejunal fluid of adult human subjects. Following vaccination, all seven subjects had a detectable anti-typhoid IgA antibody response using their peripheral blood lymphocytes (
p = 0.009). Significant rises in postvaccination anti-typhoid IgA antibody were observed in the jejunal fluid (
p = 0.033), serum (
p = 0.010) and saliva (
p = 0.050) of these subjects. This study confirms that the normal rectal mucosa is an efficient route of entry to the systemic immune system for microbial agents, and therefore may provide a further possible route of immunization with attenuated bacterial vaccines.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2363299</pmid><doi>10.1016/0264-410X(90)90047-P</doi><tpages>4</tpages></addata></record> |
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| ispartof | Vaccine, 1990-06, Vol.8 (3), p.209-212 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Administration, Rectal Adult Antibodies, Bacterial - biosynthesis Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Female Human bacterial diseases Humans IgA IgG IgM Immunoglobulin A - biosynthesis Infectious diseases intestinal immunity Intestinal Mucosa - immunology Male Medical sciences Rectal administration Salmonella typhi - immunology typhoid vaccine Typhoid-Paratyphoid Vaccines - administration & dosage Typhoid-Paratyphoid Vaccines - immunology Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology |
| title | Specific immune response in humans following rectal delivery of live typhoid vaccine |
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