Insulinemia and Blood Pressure Relationships in Patients with Primary and Secondary Hypertension, and With or Without Glucose Metabolism Impairment
In order to investigate the relationships between insulinemia and hypertension, fasting insulinemia has been assessed in 117 subjects: 69 normotensive subjects, 36 with essential hypertension, and 12 with renovascular hypertension, all untreated and newly diagnosed, classified in subgroups (euglycem...
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| Veröffentlicht in: | American journal of hypertension 1990-07, Vol.3 (7), p.521-526 |
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| creator | Marigliano, Antonio Tedde, Rinaldo Sechi, Leonardo Alberto Pala, Antonella Pisanu, Gavino Pacifico, Adolfo |
| description | In order to investigate the relationships between insulinemia and hypertension, fasting insulinemia has been assessed in 117 subjects: 69 normotensive subjects, 36 with essential hypertension, and 12 with renovascular hypertension, all untreated and newly diagnosed, classified in subgroups (euglycemic nonobese, euglycemic obese, with impaired glucose tolerance and with non-insulin-dependent diabetes mellitus). In the patients with essential hypertension fasting insulinemia was significantly higher than in normotensive subjects (P < .0005). The patients with secondary hypertension and the normotensive subjects had similar fasting insulinemia values. In each subgroup fasting insulinemia was higher in hypertensive patients than among normotensive subjects (P < .05). A significant correlation between fasting insulinemia and mean blood pressure has been found in patients with essential hypertension (r = 0.408, P < .05), but not in patients with renovascular hypertension. Our data suggest a possible direct relationship between fasting insulinemia and blood pressure, especially in obese patients or patients with impaired glucose metabolism, and that increased blood pressure per se is not an insulin resistent state. Am J Hypertens 1990:3:521–526 |
| doi_str_mv | 10.1093/ajh/3.7.521 |
| format | Article |
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In the patients with essential hypertension fasting insulinemia was significantly higher than in normotensive subjects (P < .0005). The patients with secondary hypertension and the normotensive subjects had similar fasting insulinemia values. In each subgroup fasting insulinemia was higher in hypertensive patients than among normotensive subjects (P < .05). A significant correlation between fasting insulinemia and mean blood pressure has been found in patients with essential hypertension (r = 0.408, P < .05), but not in patients with renovascular hypertension. Our data suggest a possible direct relationship between fasting insulinemia and blood pressure, especially in obese patients or patients with impaired glucose metabolism, and that increased blood pressure per se is not an insulin resistent state. 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In the patients with essential hypertension fasting insulinemia was significantly higher than in normotensive subjects (P < .0005). The patients with secondary hypertension and the normotensive subjects had similar fasting insulinemia values. In each subgroup fasting insulinemia was higher in hypertensive patients than among normotensive subjects (P < .05). A significant correlation between fasting insulinemia and mean blood pressure has been found in patients with essential hypertension (r = 0.408, P < .05), but not in patients with renovascular hypertension. Our data suggest a possible direct relationship between fasting insulinemia and blood pressure, especially in obese patients or patients with impaired glucose metabolism, and that increased blood pressure per se is not an insulin resistent state. Am J Hypertens 1990:3:521–526</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Evaluation Studies as Topic</subject><subject>Fasting - blood</subject><subject>Fasting - metabolism</subject><subject>Female</subject><subject>Glucose - metabolism</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - complications</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension, Renovascular - blood</subject><subject>Hypertension, Renovascular - complications</subject><subject>Hypertension, Renovascular - metabolism</subject><subject>Hypertension, Renovascular - physiopathology</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Insulinemia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>obesity</subject><issn>0895-7061</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUtv1DAUhS1EVaaFFWskr9jQTP2InWTJ9DEzUlsqCipiYznOjcYliYPtCPo7-MN4Hurq6uh890j3HoTeUzKnpOLn-mlzzufFXDD6Cs1oldOsYEy8RjNSViIriKRv0EkIT4SQXEp6jI5ZogQpZ-jfeghTZwforcZ6aPCic67B9x5CmDzgr9DpaN0QNnYM2A74PkkYYsB_bNwkzvbaP-82H8C4odmq1fMIPsIQ0uLZznvcws7vppsiXnaTcQHwLURdu86GHq_7UVvfp-y36KjVXYB3h3mKvl9ffbtYZTdfluuLzzeZ4YzFTBoCrGGVKaEked7qCuqaEA5ly5moeQ2cGiJkEprIgum2NIYKXepSVLKV_BR93OeO3v2eIETV22Cg6_QAbgqqqEpBmMgT-GkPGu9C8NCqcX-3okRtK1CpAsVVoVIFif5wiJ3qHpoX9vDz5Gd734YIf19s7X8pWfBCqNWPn2p5e7m4XjzcqUf-Hw4AlD8</recordid><startdate>19900701</startdate><enddate>19900701</enddate><creator>Marigliano, Antonio</creator><creator>Tedde, Rinaldo</creator><creator>Sechi, Leonardo Alberto</creator><creator>Pala, Antonella</creator><creator>Pisanu, Gavino</creator><creator>Pacifico, Adolfo</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900701</creationdate><title>Insulinemia and Blood Pressure Relationships in Patients with Primary and Secondary Hypertension, and With or Without Glucose Metabolism Impairment</title><author>Marigliano, Antonio ; Tedde, Rinaldo ; Sechi, Leonardo Alberto ; Pala, Antonella ; Pisanu, Gavino ; Pacifico, Adolfo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-6c0e2d29c8e8044fa9ebb003e8f325b3be31c056325a0672af8cc15a8a8596f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Evaluation Studies as Topic</topic><topic>Fasting - blood</topic><topic>Fasting - metabolism</topic><topic>Female</topic><topic>Glucose - metabolism</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>hypertension</topic><topic>Hypertension - blood</topic><topic>Hypertension - complications</topic><topic>Hypertension - metabolism</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension, Renovascular - blood</topic><topic>Hypertension, Renovascular - complications</topic><topic>Hypertension, Renovascular - metabolism</topic><topic>Hypertension, Renovascular - physiopathology</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Insulinemia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>obesity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marigliano, Antonio</creatorcontrib><creatorcontrib>Tedde, Rinaldo</creatorcontrib><creatorcontrib>Sechi, Leonardo Alberto</creatorcontrib><creatorcontrib>Pala, Antonella</creatorcontrib><creatorcontrib>Pisanu, Gavino</creatorcontrib><creatorcontrib>Pacifico, Adolfo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marigliano, Antonio</au><au>Tedde, Rinaldo</au><au>Sechi, Leonardo Alberto</au><au>Pala, Antonella</au><au>Pisanu, Gavino</au><au>Pacifico, Adolfo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulinemia and Blood Pressure Relationships in Patients with Primary and Secondary Hypertension, and With or Without Glucose Metabolism Impairment</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>1990-07-01</date><risdate>1990</risdate><volume>3</volume><issue>7</issue><spage>521</spage><epage>526</epage><pages>521-526</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><abstract>In order to investigate the relationships between insulinemia and hypertension, fasting insulinemia has been assessed in 117 subjects: 69 normotensive subjects, 36 with essential hypertension, and 12 with renovascular hypertension, all untreated and newly diagnosed, classified in subgroups (euglycemic nonobese, euglycemic obese, with impaired glucose tolerance and with non-insulin-dependent diabetes mellitus). In the patients with essential hypertension fasting insulinemia was significantly higher than in normotensive subjects (P < .0005). The patients with secondary hypertension and the normotensive subjects had similar fasting insulinemia values. In each subgroup fasting insulinemia was higher in hypertensive patients than among normotensive subjects (P < .05). A significant correlation between fasting insulinemia and mean blood pressure has been found in patients with essential hypertension (r = 0.408, P < .05), but not in patients with renovascular hypertension. Our data suggest a possible direct relationship between fasting insulinemia and blood pressure, especially in obese patients or patients with impaired glucose metabolism, and that increased blood pressure per se is not an insulin resistent state. Am J Hypertens 1990:3:521–526</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>2194508</pmid><doi>10.1093/ajh/3.7.521</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adult Aged Blood Pressure Body Mass Index diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Evaluation Studies as Topic Fasting - blood Fasting - metabolism Female Glucose - metabolism Glucose Tolerance Test Humans hypertension Hypertension - blood Hypertension - complications Hypertension - metabolism Hypertension - physiopathology Hypertension, Renovascular - blood Hypertension, Renovascular - complications Hypertension, Renovascular - metabolism Hypertension, Renovascular - physiopathology Insulin - blood Insulin Resistance Insulinemia Male Middle Aged obesity |
| title | Insulinemia and Blood Pressure Relationships in Patients with Primary and Secondary Hypertension, and With or Without Glucose Metabolism Impairment |
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