Dietary fiber: in vitro methods that anticipate nutrition and metabolic activity in humans
Gravimetric measurement of dietary fiber (DF) gives no indication of the biological function of any particular fiber. This study describes simple methods based on dialysis and fermentation that enable a hierarchy of fibers to be described for each of the major actions of fiber along the gastro-intes...
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| Veröffentlicht in: | The American journal of clinical nutrition 1990-07, Vol.52 (1), p.128-134 |
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| container_title | The American journal of clinical nutrition |
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| creator | Adiotomre, J Eastwood, MA Edwards, CA Brydon, WG |
| description | Gravimetric measurement of dietary fiber (DF) gives no indication of the biological function of any particular fiber. This study describes simple methods based on dialysis and fermentation that enable a hierarchy of fibers to be described for each of the major actions of fiber along the gastro-intestinal tract: nutrient absorption, sterol metabolism, cecal fermentation, and fecal bulking. These results were compared with previous metabolic studies with the same fiber isolates in humans. DF that modifies nutrient absorption can be identified by using dialysis studies, whereas identifying DF that modifies sterol metabolism, cecal fermentation, and fecal weight requires formulas that incorporate dialysis and fermentation results. Results from dialysis and fermentation predicted the action of wheat bran, pectin, guar, gum arabic, carboxymethylcellulose, gellan, tragacanth, xanthan, and karaya in humans and generated anomalous results for karaya and tragacanth. These methods could form the basis of techniques that would enable a screening of novel and processed fibers before studies in animals, including humans. |
| doi_str_mv | 10.1093/ajcn/52.1.128 |
| format | Article |
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This study describes simple methods based on dialysis and fermentation that enable a hierarchy of fibers to be described for each of the major actions of fiber along the gastro-intestinal tract: nutrient absorption, sterol metabolism, cecal fermentation, and fecal bulking. These results were compared with previous metabolic studies with the same fiber isolates in humans. DF that modifies nutrient absorption can be identified by using dialysis studies, whereas identifying DF that modifies sterol metabolism, cecal fermentation, and fecal weight requires formulas that incorporate dialysis and fermentation results. Results from dialysis and fermentation predicted the action of wheat bran, pectin, guar, gum arabic, carboxymethylcellulose, gellan, tragacanth, xanthan, and karaya in humans and generated anomalous results for karaya and tragacanth. These methods could form the basis of techniques that would enable a screening of novel and processed fibers before studies in animals, including humans.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/52.1.128</identifier><identifier>PMID: 2163190</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Bile Acids and Salts - metabolism ; Biological and medical sciences ; Dialysis ; dietary fiber ; Dietary Fiber - metabolism ; feces ; Feces - analysis ; Fermentation ; food analysis ; Galactans - metabolism ; Glucose - metabolism ; gums ; Humans ; Intestinal Absorption ; lipid metabolism ; Mannans - metabolism ; Medical sciences ; Miscellaneous ; Models, Biological ; Nutritional Physiological Phenomena ; Pectins - metabolism ; Plant Gums ; prediction ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; sterols ; stool weight ; Water - metabolism ; wheat bran ; xanthan gum</subject><ispartof>The American journal of clinical nutrition, 1990-07, Vol.52 (1), p.128-134</ispartof><rights>1990 American Society for Nutrition.</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-eb579214f2021200257a22e9646315fe7c4949240552494d31db032fd5fdd1493</citedby><cites>FETCH-LOGICAL-c305t-eb579214f2021200257a22e9646315fe7c4949240552494d31db032fd5fdd1493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19834625$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2163190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adiotomre, J</creatorcontrib><creatorcontrib>Eastwood, MA</creatorcontrib><creatorcontrib>Edwards, CA</creatorcontrib><creatorcontrib>Brydon, WG</creatorcontrib><title>Dietary fiber: in vitro methods that anticipate nutrition and metabolic activity in humans</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Gravimetric measurement of dietary fiber (DF) gives no indication of the biological function of any particular fiber. This study describes simple methods based on dialysis and fermentation that enable a hierarchy of fibers to be described for each of the major actions of fiber along the gastro-intestinal tract: nutrient absorption, sterol metabolism, cecal fermentation, and fecal bulking. These results were compared with previous metabolic studies with the same fiber isolates in humans. DF that modifies nutrient absorption can be identified by using dialysis studies, whereas identifying DF that modifies sterol metabolism, cecal fermentation, and fecal weight requires formulas that incorporate dialysis and fermentation results. Results from dialysis and fermentation predicted the action of wheat bran, pectin, guar, gum arabic, carboxymethylcellulose, gellan, tragacanth, xanthan, and karaya in humans and generated anomalous results for karaya and tragacanth. These methods could form the basis of techniques that would enable a screening of novel and processed fibers before studies in animals, including humans.</description><subject>Bile Acids and Salts - metabolism</subject><subject>Biological and medical sciences</subject><subject>Dialysis</subject><subject>dietary fiber</subject><subject>Dietary Fiber - metabolism</subject><subject>feces</subject><subject>Feces - analysis</subject><subject>Fermentation</subject><subject>food analysis</subject><subject>Galactans - metabolism</subject><subject>Glucose - metabolism</subject><subject>gums</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>lipid metabolism</subject><subject>Mannans - metabolism</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Models, Biological</subject><subject>Nutritional Physiological Phenomena</subject><subject>Pectins - metabolism</subject><subject>Plant Gums</subject><subject>prediction</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>sterols</subject><subject>stool weight</subject><subject>Water - metabolism</subject><subject>wheat bran</subject><subject>xanthan gum</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM-P1CAYhonRrOPq0aOxF711Fj5KW7yZ9WeyiQfdixdC4cNh08IIdJP976WZiZ48QfgeXl4eQl4yumdU8it9Z8KVgD3bMxgfkR2TfGw50OEx2VFKoZWsF0_Js5zvKGXQjf0FuQDWcybpjvz84LHo9NA4P2F61_jQ3PuSYrNgOUSbm3LQpdGheOOPumAT1pJ88THUQ7tReoqzN402xdebD1vCYV10yM_JE6fnjC_O6yW5_fTxx_WX9ubb56_X729aw6koLU5ikMA6BxQY1MJi0AAo-65WFA4H08lOQkeFgLqznNmJcnBWOGtZJ_kleXvKPab4e8Vc1OKzwXnWAeOa1SBHUUXwCrYn0KSYc0Knjskv9fOKUbW5VJtLJUAxVV1W_tU5eJ0WtH_ps7w6f3Oe62z07JIOxud_oXLkXQ-icq9PnNNR6V-pMrffgTJOYaCCddtLw4nA6uneY1LZeAwGrU9oirLR_6fjH-xymAc</recordid><startdate>199007</startdate><enddate>199007</enddate><creator>Adiotomre, J</creator><creator>Eastwood, MA</creator><creator>Edwards, CA</creator><creator>Brydon, WG</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199007</creationdate><title>Dietary fiber: in vitro methods that anticipate nutrition and metabolic activity in humans</title><author>Adiotomre, J ; Eastwood, MA ; Edwards, CA ; Brydon, WG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-eb579214f2021200257a22e9646315fe7c4949240552494d31db032fd5fdd1493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Bile Acids and Salts - metabolism</topic><topic>Biological and medical sciences</topic><topic>Dialysis</topic><topic>dietary fiber</topic><topic>Dietary Fiber - metabolism</topic><topic>feces</topic><topic>Feces - analysis</topic><topic>Fermentation</topic><topic>food analysis</topic><topic>Galactans - metabolism</topic><topic>Glucose - metabolism</topic><topic>gums</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>lipid metabolism</topic><topic>Mannans - metabolism</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Models, Biological</topic><topic>Nutritional Physiological Phenomena</topic><topic>Pectins - metabolism</topic><topic>Plant Gums</topic><topic>prediction</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>sterols</topic><topic>stool weight</topic><topic>Water - metabolism</topic><topic>wheat bran</topic><topic>xanthan gum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adiotomre, J</creatorcontrib><creatorcontrib>Eastwood, MA</creatorcontrib><creatorcontrib>Edwards, CA</creatorcontrib><creatorcontrib>Brydon, WG</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adiotomre, J</au><au>Eastwood, MA</au><au>Edwards, CA</au><au>Brydon, WG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary fiber: in vitro methods that anticipate nutrition and metabolic activity in humans</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1990-07</date><risdate>1990</risdate><volume>52</volume><issue>1</issue><spage>128</spage><epage>134</epage><pages>128-134</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Gravimetric measurement of dietary fiber (DF) gives no indication of the biological function of any particular fiber. This study describes simple methods based on dialysis and fermentation that enable a hierarchy of fibers to be described for each of the major actions of fiber along the gastro-intestinal tract: nutrient absorption, sterol metabolism, cecal fermentation, and fecal bulking. These results were compared with previous metabolic studies with the same fiber isolates in humans. DF that modifies nutrient absorption can be identified by using dialysis studies, whereas identifying DF that modifies sterol metabolism, cecal fermentation, and fecal weight requires formulas that incorporate dialysis and fermentation results. Results from dialysis and fermentation predicted the action of wheat bran, pectin, guar, gum arabic, carboxymethylcellulose, gellan, tragacanth, xanthan, and karaya in humans and generated anomalous results for karaya and tragacanth. These methods could form the basis of techniques that would enable a screening of novel and processed fibers before studies in animals, including humans.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>2163190</pmid><doi>10.1093/ajcn/52.1.128</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal of clinical nutrition, 1990-07, Vol.52 (1), p.128-134 |
| issn | 0002-9165 1938-3207 |
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| subjects | Bile Acids and Salts - metabolism Biological and medical sciences Dialysis dietary fiber Dietary Fiber - metabolism feces Feces - analysis Fermentation food analysis Galactans - metabolism Glucose - metabolism gums Humans Intestinal Absorption lipid metabolism Mannans - metabolism Medical sciences Miscellaneous Models, Biological Nutritional Physiological Phenomena Pectins - metabolism Plant Gums prediction Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) sterols stool weight Water - metabolism wheat bran xanthan gum |
| title | Dietary fiber: in vitro methods that anticipate nutrition and metabolic activity in humans |
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