Histamine stimulates glycogen breakdown and increases 45Ca2+ permeability in rat astrocytes in primary culture

In astrocyte-enriched cultures from rat brain hemispheres prelabeled with [3H]glucose, histamine stimulates [3H]glycogen breakdown in a concentration-dependent manner, with an EC50 of 0.6 microM. This effect can be induced by activation of both H1 and H2 receptors independently. Thus, neither 1 micr...

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Veröffentlicht in:	Molecular pharmacology 1990-06, Vol.37 (6), p.921-927
Hauptverfasser:	ARBONES, L, PICATOSTE, F, GARCIA, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Bucladesine - pharmacology Calcimycin - pharmacology Calcium - metabolism Cell Membrane Permeability - drug effects Cells, Cultured Fundamental and applied biological sciences. Psychology Glucose - metabolism Glycogen - metabolism Histamine - pharmacology Hydrolysis Kinetics Non peptidic neurotransmitters, polyamines Other biological molecules Rats Receptors, Histamine - drug effects Receptors, Histamine - metabolism Receptors, Histamine H1 - drug effects Receptors, Histamine H1 - metabolism Receptors, Histamine H2 - drug effects Receptors, Histamine H2 - metabolism
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