Effects of androgen treatment in impotent men with normal and low levels of free testosterone
The relation between sexual function and serum free testosterone (fT) levels, which represent the active fraction of circulating testosterone, was evaluated. Two groups of impotent male subjects with mild hypogonadism were treated with oral testosterone undecanoate (TU); these men presented with tT/...
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| Veröffentlicht in: | Archives of sexual behavior 1990-06, Vol.19 (3), p.223-234 |
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| creator | CARANI, C ZINI, D BALDINI, A DELLA CASA, L GHIZZANI, A MARRAMA, P |
| description | The relation between sexual function and serum free testosterone (fT) levels, which represent the active fraction of circulating testosterone, was evaluated. Two groups of impotent male subjects with mild hypogonadism were treated with oral testosterone undecanoate (TU); these men presented with tT/luteinizing hormone (LH) ratio and tT levels at the lower limits of normal. The first group had serum fT below 6.6 ng/ml, considered the lower normal value, according to our laboratory method, whereas the second group had normal fT limits. Administration of TU improved sexual function only in impotent men with low fT levels, but not in subjects with normal fT levels, even though the tT levels and the tT/LH ratio of the two groups were not significantly different. The results of our study suggest the presence of a minimum serum fT threshold, lying near the lower normal range, which determines the male sexual function. Moreover, serum fT levels were a more sensitive index than tT for identifying impotent men who can be successfully treated with androgens. |
| doi_str_mv | 10.1007/BF01541548 |
| format | Article |
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Two groups of impotent male subjects with mild hypogonadism were treated with oral testosterone undecanoate (TU); these men presented with tT/luteinizing hormone (LH) ratio and tT levels at the lower limits of normal. The first group had serum fT below 6.6 ng/ml, considered the lower normal value, according to our laboratory method, whereas the second group had normal fT limits. Administration of TU improved sexual function only in impotent men with low fT levels, but not in subjects with normal fT levels, even though the tT levels and the tT/LH ratio of the two groups were not significantly different. The results of our study suggest the presence of a minimum serum fT threshold, lying near the lower normal range, which determines the male sexual function. Moreover, serum fT levels were a more sensitive index than tT for identifying impotent men who can be successfully treated with androgens.</description><identifier>ISSN: 0004-0002</identifier><identifier>EISSN: 1573-2800</identifier><identifier>DOI: 10.1007/BF01541548</identifier><identifier>PMID: 2193636</identifier><identifier>CODEN: ASXBA8</identifier><language>eng</language><publisher>New York, NY: Kluwer Academic/Plenum</publisher><subject>Adult ; Adult. Elderly ; Androgens ; Biological and medical sciences ; Clinical Trials as Topic ; Developmental psychology ; Double-Blind Method ; Erectile Dysfunction - blood ; Erectile Dysfunction - complications ; Erectile Dysfunction - drug therapy ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypogonadism - blood ; Hypogonadism - complications ; Hypogonadism - drug therapy ; Luteinizing Hormone - blood ; Male ; Men ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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Two groups of impotent male subjects with mild hypogonadism were treated with oral testosterone undecanoate (TU); these men presented with tT/luteinizing hormone (LH) ratio and tT levels at the lower limits of normal. The first group had serum fT below 6.6 ng/ml, considered the lower normal value, according to our laboratory method, whereas the second group had normal fT limits. Administration of TU improved sexual function only in impotent men with low fT levels, but not in subjects with normal fT levels, even though the tT levels and the tT/LH ratio of the two groups were not significantly different. The results of our study suggest the presence of a minimum serum fT threshold, lying near the lower normal range, which determines the male sexual function. Moreover, serum fT levels were a more sensitive index than tT for identifying impotent men who can be successfully treated with androgens.</description><subject>Adult</subject><subject>Adult. 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Elderly</topic><topic>Androgens</topic><topic>Biological and medical sciences</topic><topic>Clinical Trials as Topic</topic><topic>Developmental psychology</topic><topic>Double-Blind Method</topic><topic>Erectile Dysfunction - blood</topic><topic>Erectile Dysfunction - complications</topic><topic>Erectile Dysfunction - drug therapy</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypogonadism - blood</topic><topic>Hypogonadism - complications</topic><topic>Hypogonadism - drug therapy</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Men</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Sexual Behavior - drug effects</topic><topic>Sexual disorders</topic><topic>Social research</topic><topic>Testosterone - analogs & derivatives</topic><topic>Testosterone - blood</topic><topic>Testosterone - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CARANI, C</creatorcontrib><creatorcontrib>ZINI, D</creatorcontrib><creatorcontrib>BALDINI, A</creatorcontrib><creatorcontrib>DELLA CASA, L</creatorcontrib><creatorcontrib>GHIZZANI, A</creatorcontrib><creatorcontrib>MARRAMA, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 27</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - International</collection><collection>Primary Sources Access & Build (Plan A) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Midwest</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Northeast</collection><collection>Primary Sources Access (Plan D) - Southeast</collection><collection>Primary Sources Access (Plan D) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Southeast</collection><collection>Primary Sources Access (Plan D) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - UK / I</collection><collection>Primary Sources Access (Plan D) - Canada</collection><collection>Primary Sources Access (Plan D) - EMEALA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - International</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - International</collection><collection>Primary Sources Access (Plan D) - West</collection><collection>Periodicals Index Online Segments 1-50</collection><collection>Primary Sources Access (Plan D) - APAC</collection><collection>Primary Sources Access (Plan D) - Midwest</collection><collection>Primary Sources Access (Plan D) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Canada</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - EMEALA</collection><collection>Primary Sources Access & Build (Plan A) - APAC</collection><collection>Primary Sources Access & Build (Plan A) - Canada</collection><collection>Primary Sources Access & Build (Plan A) - West</collection><collection>Primary Sources Access & Build (Plan A) - EMEALA</collection><collection>Primary Sources Access (Plan D) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - Midwest</collection><collection>Primary Sources Access & Build (Plan A) - North Central</collection><collection>Primary Sources Access & Build (Plan A) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - Southeast</collection><collection>Primary Sources Access (Plan D) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - APAC</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - MEA</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of sexual behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CARANI, C</au><au>ZINI, D</au><au>BALDINI, A</au><au>DELLA CASA, L</au><au>GHIZZANI, A</au><au>MARRAMA, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of androgen treatment in impotent men with normal and low levels of free testosterone</atitle><jtitle>Archives of sexual behavior</jtitle><addtitle>Arch Sex Behav</addtitle><date>1990-06-01</date><risdate>1990</risdate><volume>19</volume><issue>3</issue><spage>223</spage><epage>234</epage><pages>223-234</pages><issn>0004-0002</issn><eissn>1573-2800</eissn><coden>ASXBA8</coden><abstract>The relation between sexual function and serum free testosterone (fT) levels, which represent the active fraction of circulating testosterone, was evaluated. Two groups of impotent male subjects with mild hypogonadism were treated with oral testosterone undecanoate (TU); these men presented with tT/luteinizing hormone (LH) ratio and tT levels at the lower limits of normal. The first group had serum fT below 6.6 ng/ml, considered the lower normal value, according to our laboratory method, whereas the second group had normal fT limits. Administration of TU improved sexual function only in impotent men with low fT levels, but not in subjects with normal fT levels, even though the tT levels and the tT/LH ratio of the two groups were not significantly different. The results of our study suggest the presence of a minimum serum fT threshold, lying near the lower normal range, which determines the male sexual function. Moreover, serum fT levels were a more sensitive index than tT for identifying impotent men who can be successfully treated with androgens.</abstract><cop>New York, NY</cop><pub>Kluwer Academic/Plenum</pub><pmid>2193636</pmid><doi>10.1007/BF01541548</doi><tpages>12</tpages></addata></record> |
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| subjects | Adult Adult. Elderly Androgens Biological and medical sciences Clinical Trials as Topic Developmental psychology Double-Blind Method Erectile Dysfunction - blood Erectile Dysfunction - complications Erectile Dysfunction - drug therapy Fundamental and applied biological sciences. Psychology Humans Hypogonadism - blood Hypogonadism - complications Hypogonadism - drug therapy Luteinizing Hormone - blood Male Men Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Sexual Behavior - drug effects Sexual disorders Social research Testosterone - analogs & derivatives Testosterone - blood Testosterone - therapeutic use |
| title | Effects of androgen treatment in impotent men with normal and low levels of free testosterone |
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