Clinical significance of nuclear DNA content in pancreatic carcinoma
The nuclear DNA content or 62 pancreatic adenocarcinomas was analysed by flow cylometry from paraffinembedded material. Radical surgery could be performed in 12 of the 24 cases with diploid carcinoma, but only in 3 of the 38 cases with a non‐diploid tumour (P=0.0002); the radically resected carcinom...
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| Veröffentlicht in: | The Journal of pathology 1990-04, Vol.160 (4), p.313-320 |
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| creator | Alanen, Kalle A. Joensuu, Heikkl Klemi, Pekka J. Nevalainen, Timo I |
| description | The nuclear DNA content or 62 pancreatic adenocarcinomas was analysed by flow cylometry from paraffinembedded material. Radical surgery could be performed in 12 of the 24 cases with diploid carcinoma, but only in 3 of the 38 cases with a non‐diploid tumour (P=0.0002); the radically resected carcinomas also had a lower fraction of cells in the S‐phase (P=0.009). Non‐diploid nuclear DNA content (38 cases, 61 per cent) was associated with advanced stage (P=0.002), poor histological differentiation (grade II or III, P=0.004), and primary tumour site in the body or the tail as compared with the head (P=0.01). The median survival time of the patients with diploid carcinoma was 13±3 (SE) months, and that of the patients with non‐diploid carcinoma 3±1 months (P=0.0001). The DNA index with the cutoff value 1.4 was a slightly more powerful prognostic factor than DNA ploidy, and it was the most important independent prognostic factor in Cox's multivariate analysis (P |
| doi_str_mv | 10.1002/path.1711600407 |
| format | Article |
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Radical surgery could be performed in 12 of the 24 cases with diploid carcinoma, but only in 3 of the 38 cases with a non‐diploid tumour (P=0.0002); the radically resected carcinomas also had a lower fraction of cells in the S‐phase (P=0.009). Non‐diploid nuclear DNA content (38 cases, 61 per cent) was associated with advanced stage (P=0.002), poor histological differentiation (grade II or III, P=0.004), and primary tumour site in the body or the tail as compared with the head (P=0.01). The median survival time of the patients with diploid carcinoma was 13±3 (SE) months, and that of the patients with non‐diploid carcinoma 3±1 months (P=0.0001). The DNA index with the cutoff value 1.4 was a slightly more powerful prognostic factor than DNA ploidy, and it was the most important independent prognostic factor in Cox's multivariate analysis (P<0.001) followed by histological grade (P<0.03). We conclude that diploid pancreatic carcinomas are associated with a longer survival than the non‐diploid ones, and that radically operable carcinomas form a special subgroup with frequent diploidy and less aggressive biological behaviour.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1711600407</identifier><identifier>PMID: 2358969</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adenocarcinoma - analysis ; Adenocarcinoma - pathology ; Aged ; Biological and medical sciences ; DNA index ; DNA, Neoplasm - analysis ; Female ; Flow cylometry ; Flow Cytometry ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Interphase ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; pancreatic neoplasms ; Pancreatic Neoplasms - analysis ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Ploidies ; Prognosis ; S-phase fraction ; survival ; Survival Rate ; Tumors</subject><ispartof>The Journal of pathology, 1990-04, Vol.160 (4), p.313-320</ispartof><rights>Copyright © 1990 John Wiley & Sons, Ltd.</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5087-e749310e65adb307d028e3bff497bbfdd7c3ceb63007f93c044338d9a44a43773</citedby><cites>FETCH-LOGICAL-c5087-e749310e65adb307d028e3bff497bbfdd7c3ceb63007f93c044338d9a44a43773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1711600407$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1711600407$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6870164$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2358969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alanen, Kalle A.</creatorcontrib><creatorcontrib>Joensuu, Heikkl</creatorcontrib><creatorcontrib>Klemi, Pekka J.</creatorcontrib><creatorcontrib>Nevalainen, Timo I</creatorcontrib><title>Clinical significance of nuclear DNA content in pancreatic carcinoma</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>The nuclear DNA content or 62 pancreatic adenocarcinomas was analysed by flow cylometry from paraffinembedded material. Radical surgery could be performed in 12 of the 24 cases with diploid carcinoma, but only in 3 of the 38 cases with a non‐diploid tumour (P=0.0002); the radically resected carcinomas also had a lower fraction of cells in the S‐phase (P=0.009). Non‐diploid nuclear DNA content (38 cases, 61 per cent) was associated with advanced stage (P=0.002), poor histological differentiation (grade II or III, P=0.004), and primary tumour site in the body or the tail as compared with the head (P=0.01). The median survival time of the patients with diploid carcinoma was 13±3 (SE) months, and that of the patients with non‐diploid carcinoma 3±1 months (P=0.0001). The DNA index with the cutoff value 1.4 was a slightly more powerful prognostic factor than DNA ploidy, and it was the most important independent prognostic factor in Cox's multivariate analysis (P<0.001) followed by histological grade (P<0.03). We conclude that diploid pancreatic carcinomas are associated with a longer survival than the non‐diploid ones, and that radically operable carcinomas form a special subgroup with frequent diploidy and less aggressive biological behaviour.</description><subject>Adenocarcinoma - analysis</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>DNA index</subject><subject>DNA, Neoplasm - analysis</subject><subject>Female</subject><subject>Flow cylometry</subject><subject>Flow Cytometry</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Interphase</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>pancreatic neoplasms</subject><subject>Pancreatic Neoplasms - analysis</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Ploidies</subject><subject>Prognosis</subject><subject>S-phase fraction</subject><subject>survival</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEURUVJcJy0664Cswjdjf00-hrRlbGTuBCSUlK8FBqN1CgdaxxpTJN_XwUbl668kuCe-97jIPQZwwQDVNONHp4mWGDMASiID2iMQfJS1pKfoHEmqpJQLM7QeUrPACAlYyM0qgjLhByjxbzzwRvdFcn_Ct7lbzC26F0RtqazOhaL-1lh-jDYMBQ-FJucR6sHbwqjo_GhX-uP6NTpLtlP-_cC_by5fpwvy7uH22_z2V1pGNSitIJKgsFyptuGgGihqi1pnKNSNI1rW2GIsQ0nAMJJYoBSQupWako1JUKQC_RlN3cT-5etTYNa-2Rs1-lg-21SQtZUVpIdBTHjtRC8yuB0B5rYpxStU5vo1zq-KQzqXbB6F6z-Cc6Ny_3obbO27YHfG8351T7XKWt1Mfvy6YDlvYA5zdjXHfbHd_bt2Fb1ffa4_O-Ictf2abCvh7aOvxUXRDC1ur9VPxZ1tWKLpeLkLwOooss</recordid><startdate>199004</startdate><enddate>199004</enddate><creator>Alanen, Kalle A.</creator><creator>Joensuu, Heikkl</creator><creator>Klemi, Pekka J.</creator><creator>Nevalainen, Timo I</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>199004</creationdate><title>Clinical significance of nuclear DNA content in pancreatic carcinoma</title><author>Alanen, Kalle A. ; Joensuu, Heikkl ; Klemi, Pekka J. ; Nevalainen, Timo I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5087-e749310e65adb307d028e3bff497bbfdd7c3ceb63007f93c044338d9a44a43773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adenocarcinoma - analysis</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>DNA index</topic><topic>DNA, Neoplasm - analysis</topic><topic>Female</topic><topic>Flow cylometry</topic><topic>Flow Cytometry</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Interphase</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>pancreatic neoplasms</topic><topic>Pancreatic Neoplasms - analysis</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Ploidies</topic><topic>Prognosis</topic><topic>S-phase fraction</topic><topic>survival</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alanen, Kalle A.</creatorcontrib><creatorcontrib>Joensuu, Heikkl</creatorcontrib><creatorcontrib>Klemi, Pekka J.</creatorcontrib><creatorcontrib>Nevalainen, Timo I</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alanen, Kalle A.</au><au>Joensuu, Heikkl</au><au>Klemi, Pekka J.</au><au>Nevalainen, Timo I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of nuclear DNA content in pancreatic carcinoma</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>1990-04</date><risdate>1990</risdate><volume>160</volume><issue>4</issue><spage>313</spage><epage>320</epage><pages>313-320</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>The nuclear DNA content or 62 pancreatic adenocarcinomas was analysed by flow cylometry from paraffinembedded material. Radical surgery could be performed in 12 of the 24 cases with diploid carcinoma, but only in 3 of the 38 cases with a non‐diploid tumour (P=0.0002); the radically resected carcinomas also had a lower fraction of cells in the S‐phase (P=0.009). Non‐diploid nuclear DNA content (38 cases, 61 per cent) was associated with advanced stage (P=0.002), poor histological differentiation (grade II or III, P=0.004), and primary tumour site in the body or the tail as compared with the head (P=0.01). The median survival time of the patients with diploid carcinoma was 13±3 (SE) months, and that of the patients with non‐diploid carcinoma 3±1 months (P=0.0001). The DNA index with the cutoff value 1.4 was a slightly more powerful prognostic factor than DNA ploidy, and it was the most important independent prognostic factor in Cox's multivariate analysis (P<0.001) followed by histological grade (P<0.03). We conclude that diploid pancreatic carcinomas are associated with a longer survival than the non‐diploid ones, and that radically operable carcinomas form a special subgroup with frequent diploidy and less aggressive biological behaviour.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>2358969</pmid><doi>10.1002/path.1711600407</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenocarcinoma - analysis Adenocarcinoma - pathology Aged Biological and medical sciences DNA index DNA, Neoplasm - analysis Female Flow cylometry Flow Cytometry Gastroenterology. Liver. Pancreas. Abdomen Humans Interphase Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences pancreatic neoplasms Pancreatic Neoplasms - analysis Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Ploidies Prognosis S-phase fraction survival Survival Rate Tumors |
| title | Clinical significance of nuclear DNA content in pancreatic carcinoma |
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