Inhibition of HIV-1 in monocyte/macrophage cultures by 2',3'-dideoxycytidine-5'-triphosphate, free and in liposomes

The antiviral effects of 2',3'-dideoxycytidine (ddC), 2',3'-dideoxycytidine-5'-triphosphate (ddCTP) and liposome-encapsulated ddCTP [L(ddCTP)] were compared in cultured human monocyte-macrophages (M/M) infected with HIV-1. These treatments inhibited virus replication at nano...

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Veröffentlicht in:	AIDS research and human retroviruses 1990-05, Vol.6 (5), p.691-702
Hauptverfasser:	SZEBENI, J, WAHL, S. M, BETAGERI, G. V, WAHL, L. M, GARTNER, S, POPOVIC, M, PARKER, R. J, BLACK, C. D. V, WEINSTEIN, J. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - drug therapy AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies - immunology Antiviral agents Antiviral Agents - administration & dosage Antiviral Agents - blood Antiviral Agents - pharmacology Biological and medical sciences Capsules Cells, Cultured Chemical Phenomena Chemistry Clinical Trials as Topic Deoxycytosine Nucleotides - administration & dosage Dideoxynucleotides Drug Carriers HIV-1 - drug effects Humans Immunoglobulin G - immunology Kinetics Liposomes - immunology Macrophages - drug effects Macrophages - microbiology Medical sciences Monocytes - drug effects Monocytes - microbiology Pharmacology. Drug treatments Virus Replication - drug effects Zalcitabine - administration & dosage Zalcitabine - blood Zalcitabine - pharmacology
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