Effect of intracerebroventricular and systemic injections of caerulein, a CCK analogue, on electrical self-stimulation and its interaction with the CCKA receptor antagonist, L-364,718 (MK-329)

Systemic administration of caerulein (10-100 micrograms/kg SC), a potent analogue of cholecystokinin, caused a profound dose-related depression of variable-interval self-stimulation, followed by progressive recovery within 60 min. Intracerebroventricular injection of caerulein (3-1000 ng) was not mo...

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Veröffentlicht in:Psychopharmacology 1990, Vol.101 (3), p.384-389
Hauptverfasser: Hamilton, M H, Rose, I C, Herberg, L J, de Belleroche, J S
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Sprache:eng
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