μ-Opiate receptor binding in the medial preoptic area is cyclical and sexually dimorphic
The density and distribution of μ- and κ-opiate receptors in the medial preoptic area (MPOA) of male and female rats across the estrous cycle was examined using quantitative in vitro autoradiography of [ 3H]D-Ala 2,MePhe 4,Gly-ol 5-enkephalin (DAGO), [ 3H]naloxone and [ 3H]bremazocine binding. While...
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| Veröffentlicht in: | Brain research 1990-05, Vol.515 (1), p.187-192 |
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| creator | Hammer, Ronald P. |
| description | The density and distribution of μ- and κ-opiate receptors in the medial preoptic area (MPOA) of male and female rats across the estrous cycle was examined using quantitative in vitro autoradiography of [
3H]D-Ala
2,MePhe
4,Gly-ol
5-enkephalin (DAGO), [
3H]naloxone and [
3H]bremazocine binding. While no difference in κ-receptor labeling was observed across sex or estrous stage, selective μ-receptor labeling with [
3H]DAGO revealed a significant variation of density and distribution in the MPOA across the estrous cycle and between sexes. A dense concentration of μ-receptors located in the central, sexually dimorphic portion of the MPOA was observed during metestrus and diestrus in females, but not during proestrus nor in males. This region appeared to be the same as that labeled similarly using [
3H]naloxone. These results suggest that a regional substrate for functional activation by endogenous opiod peptides (e.g. β-endorphin) is cyclically regulated in females, which may explain the gonadal streoid-dependent effects of MPOA β-endorphin on lordosis and luteinizing hormone secretion in females. |
| doi_str_mv | 10.1016/0006-8993(90)90595-3 |
| format | Article |
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3H]D-Ala
2,MePhe
4,Gly-ol
5-enkephalin (DAGO), [
3H]naloxone and [
3H]bremazocine binding. While no difference in κ-receptor labeling was observed across sex or estrous stage, selective μ-receptor labeling with [
3H]DAGO revealed a significant variation of density and distribution in the MPOA across the estrous cycle and between sexes. A dense concentration of μ-receptors located in the central, sexually dimorphic portion of the MPOA was observed during metestrus and diestrus in females, but not during proestrus nor in males. This region appeared to be the same as that labeled similarly using [
3H]naloxone. These results suggest that a regional substrate for functional activation by endogenous opiod peptides (e.g. β-endorphin) is cyclically regulated in females, which may explain the gonadal streoid-dependent effects of MPOA β-endorphin on lordosis and luteinizing hormone secretion in females.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(90)90595-3</identifier><identifier>PMID: 2162717</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Benzomorphans - metabolism ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Endorphins - metabolism ; Enkephalin, Ala-MePhe-Gly ; Enkephalins - metabolism ; Estrous cycle ; Estrus - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Male ; Medial preoptic area ; Naloxone - metabolism ; Preoptic Area - metabolism ; Preoptic Area - physiology ; Rats ; Rats, Inbred Strains ; Receptors, Opioid - metabolism ; Receptors, Opioid, mu ; Sex Characteristics ; Sexual dimorphism ; Vertebrates: nervous system and sense organs ; μ-Opioid receptor</subject><ispartof>Brain research, 1990-05, Vol.515 (1), p.187-192</ispartof><rights>1990 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-a3e102ff4e8df5fbd13a21e44e4f08eb70c4f193714ee61b7cb0f0a95ad6c6133</citedby><cites>FETCH-LOGICAL-c417t-a3e102ff4e8df5fbd13a21e44e4f08eb70c4f193714ee61b7cb0f0a95ad6c6133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899390905953$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6892820$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2162717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hammer, Ronald P.</creatorcontrib><title>μ-Opiate receptor binding in the medial preoptic area is cyclical and sexually dimorphic</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The density and distribution of μ- and κ-opiate receptors in the medial preoptic area (MPOA) of male and female rats across the estrous cycle was examined using quantitative in vitro autoradiography of [
3H]D-Ala
2,MePhe
4,Gly-ol
5-enkephalin (DAGO), [
3H]naloxone and [
3H]bremazocine binding. While no difference in κ-receptor labeling was observed across sex or estrous stage, selective μ-receptor labeling with [
3H]DAGO revealed a significant variation of density and distribution in the MPOA across the estrous cycle and between sexes. A dense concentration of μ-receptors located in the central, sexually dimorphic portion of the MPOA was observed during metestrus and diestrus in females, but not during proestrus nor in males. This region appeared to be the same as that labeled similarly using [
3H]naloxone. These results suggest that a regional substrate for functional activation by endogenous opiod peptides (e.g. β-endorphin) is cyclically regulated in females, which may explain the gonadal streoid-dependent effects of MPOA β-endorphin on lordosis and luteinizing hormone secretion in females.</description><subject>Animals</subject><subject>Benzomorphans - metabolism</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Endorphins - metabolism</subject><subject>Enkephalin, Ala-MePhe-Gly</subject><subject>Enkephalins - metabolism</subject><subject>Estrous cycle</subject><subject>Estrus - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Medial preoptic area</subject><subject>Naloxone - metabolism</subject><subject>Preoptic Area - metabolism</subject><subject>Preoptic Area - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Opioid - metabolism</subject><subject>Receptors, Opioid, mu</subject><subject>Sex Characteristics</subject><subject>Sexual dimorphism</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>μ-Opioid receptor</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQh60KVJa2bwCSDwjRQ-g4dvzngoQqaCtV6gUOnCzHGVOjbBLsbNV9N56BZ8JhV3tsTyPr93lm9A0hbxh8ZMDkBQDIShvDPxg4N9CYpuJHZMW0qitZC3hBVgfkFXmd86_y5NzAMTmumawVUyvy4--f6m6Kbkaa0OM0j4m2ceji8JPGgc73SNfYRdfTKeE4zdFTl9DRmKnf-j76krihoxkfN67vt7SL6zFN99GfkpfB9RnP9vWEfP_65dvldXV7d3Vz-fm28oKpuXIcGdQhCNRdaELbMe5qhkKgCKCxVeBFYIYrJhAla5VvIYAzjeukl4zzE_J-13dK4-8N5tmuY_bY927AcZOtMloILfSzIGukKhwUUOxAn8acEwY7pbh2aWsZ2EW9Xbzaxas1YP-rt8sib_f9N21xdvi0d13yd_vc5aItJDf4mA-Y1KbW9TL90w7DIu0hYrLZRxx8uUK50Gy7MT69xz9HTaCy</recordid><startdate>19900507</startdate><enddate>19900507</enddate><creator>Hammer, Ronald P.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19900507</creationdate><title>μ-Opiate receptor binding in the medial preoptic area is cyclical and sexually dimorphic</title><author>Hammer, Ronald P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-a3e102ff4e8df5fbd13a21e44e4f08eb70c4f193714ee61b7cb0f0a95ad6c6133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Benzomorphans - metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Endorphins - metabolism</topic><topic>Enkephalin, Ala-MePhe-Gly</topic><topic>Enkephalins - metabolism</topic><topic>Estrous cycle</topic><topic>Estrus - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medial preoptic area</topic><topic>Naloxone - metabolism</topic><topic>Preoptic Area - metabolism</topic><topic>Preoptic Area - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Opioid - metabolism</topic><topic>Receptors, Opioid, mu</topic><topic>Sex Characteristics</topic><topic>Sexual dimorphism</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>μ-Opioid receptor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hammer, Ronald P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hammer, Ronald P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>μ-Opiate receptor binding in the medial preoptic area is cyclical and sexually dimorphic</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1990-05-07</date><risdate>1990</risdate><volume>515</volume><issue>1</issue><spage>187</spage><epage>192</epage><pages>187-192</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The density and distribution of μ- and κ-opiate receptors in the medial preoptic area (MPOA) of male and female rats across the estrous cycle was examined using quantitative in vitro autoradiography of [
3H]D-Ala
2,MePhe
4,Gly-ol
5-enkephalin (DAGO), [
3H]naloxone and [
3H]bremazocine binding. While no difference in κ-receptor labeling was observed across sex or estrous stage, selective μ-receptor labeling with [
3H]DAGO revealed a significant variation of density and distribution in the MPOA across the estrous cycle and between sexes. A dense concentration of μ-receptors located in the central, sexually dimorphic portion of the MPOA was observed during metestrus and diestrus in females, but not during proestrus nor in males. This region appeared to be the same as that labeled similarly using [
3H]naloxone. These results suggest that a regional substrate for functional activation by endogenous opiod peptides (e.g. β-endorphin) is cyclically regulated in females, which may explain the gonadal streoid-dependent effects of MPOA β-endorphin on lordosis and luteinizing hormone secretion in females.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2162717</pmid><doi>10.1016/0006-8993(90)90595-3</doi><tpages>6</tpages></addata></record> |
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| ispartof | Brain research, 1990-05, Vol.515 (1), p.187-192 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Benzomorphans - metabolism Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Endorphins - metabolism Enkephalin, Ala-MePhe-Gly Enkephalins - metabolism Estrous cycle Estrus - metabolism Female Fundamental and applied biological sciences. Psychology Male Medial preoptic area Naloxone - metabolism Preoptic Area - metabolism Preoptic Area - physiology Rats Rats, Inbred Strains Receptors, Opioid - metabolism Receptors, Opioid, mu Sex Characteristics Sexual dimorphism Vertebrates: nervous system and sense organs μ-Opioid receptor |
| title | μ-Opiate receptor binding in the medial preoptic area is cyclical and sexually dimorphic |
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