Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes
In barbiturate anaesthetized spinal cats antibody microprobes were used to examine release of immunoreactive neurokinin A following cutaneous thermal and mechanical stimulation. In the absence of peripheral stimuli, microprobes detected a diffuse basal presence of immunoreactive neurokinin A. Noxiou...
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| Veröffentlicht in: | Neuroscience 1990, Vol.35 (1), p.195-202 |
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| creator | Duggan, A.W. Hope, P.J. Jarrott, B. Schaible, H.-G. Fleetwood-Walker, S.M. |
| description | In barbiturate anaesthetized spinal cats antibody microprobes were used to examine release of immunoreactive neurokinin A following cutaneous thermal and mechanical stimulation. In the absence of peripheral stimuli, microprobes detected a diffuse basal presence of immunoreactive neurokinin A. Noxious mechanical and to a lesser extent noxious thermal stimuli increased the levels of immunoreactive neurokinin A diffusely throughout the dorsal horn which, in many cases, spread into the adjacent white matter. These diffuse stimulus-evoked increases contrast with previous experiments where the same stimuli produced discrete focal increases in levels of immunoreactive substance P. Evidence was obtained that released immunoreactive neurokinin A persisted in the spinal cord for at least 30 min beyond the period of stimulation.
Neurokinin A needs consideration as the agent responsible for the long-lasting increases in excitability of some spinal neurons found by several laboratories to follow a brief input from unmyelinated primary afferents. |
| doi_str_mv | 10.1016/0306-4522(90)90134-P |
| format | Article |
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Neurokinin A needs consideration as the agent responsible for the long-lasting increases in excitability of some spinal neurons found by several laboratories to follow a brief input from unmyelinated primary afferents.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/0306-4522(90)90134-P</identifier><identifier>PMID: 2163031</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cats ; Fundamental and applied biological sciences. Psychology ; Immunohistochemistry ; immunoreactive ; neurokinin A ; Neurokinin A - metabolism ; NKA ; Nociceptors - metabolism ; Nociceptors - physiology ; Pain - metabolism ; PBS ; phosphate-buffered saline ; Skin - innervation ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Spinal Cord - metabolism ; Spinal Cord - physiopathology ; substance P ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 1990, Vol.35 (1), p.195-202</ispartof><rights>1990 IBRO</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-4d73216e82af542c8358ca397257e00f8b67fd7d7b066862b7b9cde19024c30d3</citedby><cites>FETCH-LOGICAL-c468t-4d73216e82af542c8358ca397257e00f8b67fd7d7b066862b7b9cde19024c30d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0306-4522(90)90134-P$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6864290$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2163031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duggan, A.W.</creatorcontrib><creatorcontrib>Hope, P.J.</creatorcontrib><creatorcontrib>Jarrott, B.</creatorcontrib><creatorcontrib>Schaible, H.-G.</creatorcontrib><creatorcontrib>Fleetwood-Walker, S.M.</creatorcontrib><title>Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>In barbiturate anaesthetized spinal cats antibody microprobes were used to examine release of immunoreactive neurokinin A following cutaneous thermal and mechanical stimulation. In the absence of peripheral stimuli, microprobes detected a diffuse basal presence of immunoreactive neurokinin A. Noxious mechanical and to a lesser extent noxious thermal stimuli increased the levels of immunoreactive neurokinin A diffusely throughout the dorsal horn which, in many cases, spread into the adjacent white matter. These diffuse stimulus-evoked increases contrast with previous experiments where the same stimuli produced discrete focal increases in levels of immunoreactive substance P. Evidence was obtained that released immunoreactive neurokinin A persisted in the spinal cord for at least 30 min beyond the period of stimulation.
Neurokinin A needs consideration as the agent responsible for the long-lasting increases in excitability of some spinal neurons found by several laboratories to follow a brief input from unmyelinated primary afferents.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunohistochemistry</subject><subject>immunoreactive</subject><subject>neurokinin A</subject><subject>Neurokinin A - metabolism</subject><subject>NKA</subject><subject>Nociceptors - metabolism</subject><subject>Nociceptors - physiology</subject><subject>Pain - metabolism</subject><subject>PBS</subject><subject>phosphate-buffered saline</subject><subject>Skin - innervation</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Spinal Cord - metabolism</subject><subject>Spinal Cord - physiopathology</subject><subject>substance P</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUV2P1CAUJUazjqv_QBMejNHErlBoaV9MNhu_kk3c-PFMKNw6V1sYge66v8i_KXUm86g8AOGec-85HEIec3bGGW9fMcHaSjZ1_bxnL3rGhayu7pAN75SoVCPlXbI5Qu6TByl9Z2U1UpyQk5q3ggm-Ib8_wQQmwUuadhGMo8Y7uoOYMGXwFmgYKc7z4kOp2ozXQD0sMfxAj56e07LlLVAXYjIT3YboV8b6ZE2mY5imcIP-G_XhF4YlUbtk42G9pYzzMpmMwZ_Rz3lxCIneYN4WCRmH4G7pjDaGXQwDpIfk3mimBI8O5yn5-vbNl4v31eXHdx8uzi8rK9suV9IpUbxBV5uxkbXtRNNZI3pVNwoYG7uhVaNTTg2sbbu2HtTQWwe8Z7W0gjlxSp7t-5axPxdIWc-YLEzTXrVWfSdlo-R_gbxpuah7VoByDyxeUoow6l3E2cRbzZleg9RrSnpNSfdM_w1SXxXak0P_ZZjBHUmH5Er96aFukjXTGI23mI6wYk7up7_ew6B82jVC1MniGqzDCDZrF_DfOv4AGte8_g</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Duggan, A.W.</creator><creator>Hope, P.J.</creator><creator>Jarrott, B.</creator><creator>Schaible, H.-G.</creator><creator>Fleetwood-Walker, S.M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes</title><author>Duggan, A.W. ; Hope, P.J. ; Jarrott, B. ; Schaible, H.-G. ; Fleetwood-Walker, S.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-4d73216e82af542c8358ca397257e00f8b67fd7d7b066862b7b9cde19024c30d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunohistochemistry</topic><topic>immunoreactive</topic><topic>neurokinin A</topic><topic>Neurokinin A - metabolism</topic><topic>NKA</topic><topic>Nociceptors - metabolism</topic><topic>Nociceptors - physiology</topic><topic>Pain - metabolism</topic><topic>PBS</topic><topic>phosphate-buffered saline</topic><topic>Skin - innervation</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Spinal Cord - metabolism</topic><topic>Spinal Cord - physiopathology</topic><topic>substance P</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duggan, A.W.</creatorcontrib><creatorcontrib>Hope, P.J.</creatorcontrib><creatorcontrib>Jarrott, B.</creatorcontrib><creatorcontrib>Schaible, H.-G.</creatorcontrib><creatorcontrib>Fleetwood-Walker, S.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duggan, A.W.</au><au>Hope, P.J.</au><au>Jarrott, B.</au><au>Schaible, H.-G.</au><au>Fleetwood-Walker, S.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1990</date><risdate>1990</risdate><volume>35</volume><issue>1</issue><spage>195</spage><epage>202</epage><pages>195-202</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>In barbiturate anaesthetized spinal cats antibody microprobes were used to examine release of immunoreactive neurokinin A following cutaneous thermal and mechanical stimulation. In the absence of peripheral stimuli, microprobes detected a diffuse basal presence of immunoreactive neurokinin A. Noxious mechanical and to a lesser extent noxious thermal stimuli increased the levels of immunoreactive neurokinin A diffusely throughout the dorsal horn which, in many cases, spread into the adjacent white matter. These diffuse stimulus-evoked increases contrast with previous experiments where the same stimuli produced discrete focal increases in levels of immunoreactive substance P. Evidence was obtained that released immunoreactive neurokinin A persisted in the spinal cord for at least 30 min beyond the period of stimulation.
Neurokinin A needs consideration as the agent responsible for the long-lasting increases in excitability of some spinal neurons found by several laboratories to follow a brief input from unmyelinated primary afferents.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2163031</pmid><doi>10.1016/0306-4522(90)90134-P</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cats Fundamental and applied biological sciences. Psychology Immunohistochemistry immunoreactive neurokinin A Neurokinin A - metabolism NKA Nociceptors - metabolism Nociceptors - physiology Pain - metabolism PBS phosphate-buffered saline Skin - innervation Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - metabolism Spinal Cord - physiopathology substance P Vertebrates: nervous system and sense organs |
| title | Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes |
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