Cross-linked growth hormone dimers have enhanced biological activity

In this study we have investigated the effect on the bioactivity of pituitary-derived human growth hormone (hGH) and recombinant bovine (b) GH after the addition of various concentrations of the water soluble cross-linking agent 1-ethyl-3(3-dimethylaminopropyl) carbodiimide (EDC; 6.25-100 mg/ml). Th...

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Veröffentlicht in:	European journal of endocrinology 1998-04, Vol.138 (4), p.449-459
Hauptverfasser:	MOCKRIDGE, J. W, ASTON, R, MORRELL, D. J, HOLDER, A. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cartilage - drug effects Cartilage - metabolism Cattle Cross-Linking Reagents Dimerization Disease Models, Animal Dose-Response Relationship, Drug Dwarfism, Pituitary - drug therapy Fundamental and applied biological sciences. Psychology Growth Hormone - chemistry Growth Hormone - pharmacology Human Growth Hormone - chemistry Human Growth Hormone - pharmacology Mice Mice, Inbred Strains Proteins Structure-Activity Relationship
Online-Zugang:	Volltext
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