Adenoviral gene transfer in arteries of hypercholesterolemic nonhuman primates

Arterial gene transfer with adenoviral vectors is a promising approach for the treatment and prevention of vascular disorders. However, in small animals such as rats and rabbits adenoviral vectors can have deleterious effects on the artery wall. The effects of adenovirus in primate arteries have not...

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Veröffentlicht in:	Human gene therapy 1998-04, Vol.9 (6), p.815-821
Hauptverfasser:	Schneider, D B, Fly, C A, Dichek, D A, Geary, R L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Animals Antibody Formation beta-Galactosidase - biosynthesis beta-Galactosidase - genetics Brachial Artery - pathology Cell Division Endothelium, Vascular - pathology Female Gene Transfer Techniques Genetic Therapy Humans Hypercholesterolemia - pathology Hypercholesterolemia - therapy Macaca fascicularis Macrophages - pathology Rabbits Rats T-Lymphocytes - pathology
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