Buccal Absorption of Midazolam: Pharmacokinetics and EEG Pharmacodynamics

Purpose: To determine whether buccal/sublingual administration of midazolam (MDL) would lead to detectable venous concentrations and EEG changes in 10 healthy volunteers. Methods: The study consisted of an open‐label and a double‐blind phases. Subjects held 10 mg MDL in 2 ml peppermint‐flavored flui...

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Veröffentlicht in:	Epilepsia (Copenhagen) 1998-03, Vol.39 (3), p.290-294
Hauptverfasser:	Scott, Rod C., Besag, Frank M. C., Boyd, Stewart G., Berry, David, Neville, Brian G. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Administration, Buccal Administration, Sublingual Adult Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Buccal/sublingual Double-Blind Method Electroencephalography - drug effects Humans Medical sciences Midazolam Midazolam - administration & dosage Midazolam - pharmacokinetics Midazolam - pharmacology Monitoring, Physiologic Neuropharmacology Pharmacology. Drug treatments Placebos Status epilepticus Status Epilepticus - drug therapy
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